1,3-Disubstituted 4-Aminopiperidine (cas 13035-19-3)s as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors

Add time:09/10/2019    Source:sciencedirect.com

In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR could be transferred to the 2-aminobenzo[a]quinolizine series, leading to highly active DPP-IV inhibitors.

We also recommend Trading Suppliers and Manufacturers of 4-Aminopiperidine (cas 13035-19-3). Pls Click Website Link as below: cas 13035-19-3 suppliers

Prev:4-Aminopiperidine (cas 13035-19-3) derivatives as a new class of potent cognition enhancing drugs
Next:Identification of substituted 4-Aminopiperidine (cas 13035-19-3)s and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity)