A facile one-pot synthesis of 2-(2-pyridyl)quinolines via Povarov reaction
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Add time:09/06/2019 Source:sciencedirect.com
An efficient synthesis of 2-(2-pyridyl)quinolines was achieved via a three-component Povarov reaction of aromatic aldehydes, anilines, and ethyl vinyl ether under boron trifluoride methyl etherate (BF3·O(CH3)2) acid catalysis. The developed methodology for the preparation of 2-(2-pyridyl)quinolines offers several advantages over previous methods including mild reaction conditions, easy work-up, a wide range of substrate applicability, and products in good yields.
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