Evaluation of anticancer activity of α-defensins purified from neutrophils trapped in leukoreduction filters
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Add time:09/10/2019 Source:sciencedirect.com
AimsThe α-defensins or human neutrophil peptides (HNP 1–3) that exist in azurophilic granules are found to have anticancer activity. The pattern of disulfide bonds in α-defensins is crucial for the functional properties. Therefore, synthesis using the chemical and recombinant approaches is a challenging. A safe source for the production of α-defensins can be the use of leukoreduction filters in blood banks that contain large quantities of neutrophils and are discarded after use. The aim of this study was to purify α-defensins from neutrophils trapped in leukofilters and to investigate its anticancer activity.
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