Original articleDirect amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions
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Add time:09/08/2019 Source:sciencedirect.com
A metal-free synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2-yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives.
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