CF3-Carbenoid functionalization of N-(pyrimidin-2-yl)indole catalyzed by cobalt complexes: Ligand control of selectivity
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Add time:09/10/2019 Source:sciencedirect.com
The carbonyl cobalt complex Cp*Co(CO)I2 catalyzes carbenoid Co alkylation of N-(pyrimidin-2-yl)indole with methyl 3,3,3-trifluoro-2-diazopropionate regioselectively giving 2-substituted indole, while the N,N’-ligated cations [CpCo(L)I]+ (L = bipy, phen) provide 3-substitution exclusively. The structure of [CpCo(phen)I]PF6 was investigated by X-ray diffraction.
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