2-Hydroxy-4-Isopropylbenzaldehyde (cas 122-03-2), a potent partial tyrosinase inhibitor

Add time:09/04/2019    Source:sciencedirect.com

Chamaecin (2-hydroxy-4-isopropylbenzaldehyde) was synthesized and tested for its tyrosinase inhibitory activity. It partially inhibits the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) catalyzed by mushroom tyrosinase with an IC50 of 2.3 μM. The inhibition kinetics analyzed by Dixon plots found that chamaecin is a mixed type inhibitor. This inhibition may come in part from its ability to form a Schiff base with a primary amino group in the enzyme.

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