CommunicationEnzymatic clickable functionalization of peptides via computationally engineered PEPTIDE AMIDASE (cas 138674-18-7)

Add time:09/05/2019    Source:sciencedirect.com

Directed peptides C-terminal modification enabled by the engineered biomolecular catalyst – peptide amidase 12B has been achieved via computational protein engineering. The engineered enzyme exhibits great promising potential in the C-terminal modification of opioid peptides using prop-2-yn-1-amine (PYA) or prop-2-en-1-amine (PEA) as the nucleophile. A variety of opioid peptides could be readily functionalized at the C-terminal chain in high yield in a mild and selective manner. Notably, modified opioid peptides bearing alkynyl moiety could be further functionalized through well-established click reaction.

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