1,n-Diamines. Part 3: Microwave-assisted synthesis of N-acyl-N′-arylhexahydropyrimidines and hexahydro-1,3-diazepines
-
Add time:09/07/2019 Source:sciencedirect.com
In this Letter we present a method for the synthesis of N-acyl-N′-arylhexahydropyrimidines 1, by ring closure of N-acyl-N′-aryl-1,3-propanediamines 3 with formaldehyde. Cyclodehydrations were performed in aqueous medium under microwave irradiation, and led to high yields of the desired compounds in remarkably short reaction times. The method also allowed for the synthesis of hitherto unreported N-acyl-N′-arylhexahydro-1,3-diazepines 2. The acyclic tetramethylenic precursors 4 were synthesized by selective functionalization of N-arylputrescines.
We also recommend Trading Suppliers and Manufacturers of hexahydro-1-(4-nitrophenyl)-1H-azepine (cas 13663-23-5). Pls Click Website Link as below: cas 13663-23-5 suppliers
Prev:1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines
Next:A contribution to the elucidation of the biosynthesis of 3-chloro-4-(3′-chloro-2′-nitrophenyl)-1H-pyrrole (pyrrolnitrin)) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- cis-3a-(o-Nitrophenyl)octahydroindol-4-one. building blocks for the synthesis of indole alkaloids09/24/2019
- Study of chiral β-enaminones prepared from pyrrolidine, cytisine, salsoline and 2-amino-1-(4-nitrophenyl)propane-1,3-diol: resolution of salsoline via diastereomeric modified carane-type β-enaminones09/10/2019
- Synthesis of a hexahydro-2H-imidazo[4,5-g]isoquinolin-2-one derivative as an isostere of catecholamine-based selective dopamine D-1 antagonists09/09/2019
- A contribution to the elucidation of the biosynthesis of 3-chloro-4-(3′-chloro-2′-nitrophenyl)-1H-pyrrole (pyrrolnitrin)09/08/2019
- 1,n-Diamines. Part 4: synthesis of 1-aryl-2-alkyl-1,4,5,6,7,8-hexahydro-1,3-diazocines09/06/2019
