Facile and efficient addition of terminal alkynes to benzotriazole esters: synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) using ynones as the key intermediate
-
Add time:09/24/2019 Source:sciencedirect.com
From the perspective of synthesis, ynones are compounds of considerable interest because of their occurrence in a wide variety of biologically active molecules and as key synthetic intermediates. In this context, a facile and highly efficient synthesis of ynones was developed based on the high reactivity of benzotriazole esters formed in situ. Lithium acetylides can alkylate various carboxylic acids in yields ranging from 60% to 92%. To determine whether our methodology is useful for synthesising complex and biologically relevant molecules, we synthesise D-ERYTHRO-SPHINGOSINE (cas 123-78-4) in four steps and with 33% overall yield from l-serine.
We also recommend Trading Suppliers and Manufacturers of D-ERYTHRO-SPHINGOSINE (cas 123-78-4). Pls Click Website Link as below: cas 123-78-4 suppliers
Prev:Stereoselective synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and l-lyxo-phytosphingosine
Next:Synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and D-erythro-sphinganine via 3-ketosphinganine) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Diastereoselective nickel-catalyzed reductive couplings of aminoaldehydes and alkynylsilanes: application to the synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4)09/29/2019
- Characterization of N,N,-dimethyl-D-ERYTHRO-SPHINGOSINE (cas 123-78-4)-induced apoptosis and signaling in U937 cells: Independence of sphingosine kinase inhibition09/28/2019
- Synthesis of an orthogonally protected d-(+)-erythro-sphingosine10/01/2019
- A simple and low cost synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and d-erythro-azidosphingosine from d-ribo-phytosphingosine: glycosphingolipid precursors09/27/2019
- Highly efficient stereoselective synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and d-lyxo-phytosphingosine09/26/2019
- Synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and D-erythro-sphinganine via 3-ketosphinganine09/25/2019
- Stereoselective synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and l-lyxo-phytosphingosine09/10/2019
- Inhibition of arachidonic acid release and cytosolic phospholipase A2α activity by D-ERYTHRO-SPHINGOSINE (cas 123-78-4)09/09/2019
- A diversity oriented synthesis of D-ERYTHRO-SPHINGOSINE (cas 123-78-4) and siblings09/08/2019