Catalyst free synthesis of mono- and disubstituted pyrimidines from O-acyl oximes
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Add time:09/28/2019 Source:sciencedirect.com
Transition-metal or iodine catalyzed transformations of O-acyl oximes to various N-heterocycles are well established. Herein, we report a catalyst free, oxime carboxylate based, three-component condensation method to access mono- and disubstituted pyrimidines. A broad range of substituted pyrimidines were prepared in moderate to excellent yields. Control experiments reveal that in situ generated formamidine is the key intermediate.
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