Original ArticleAn open pilot study investigating the use of a strong sublingual opioid (phenazocine (cas 127-35-5)) for postoperative analgesia

Add time:09/24/2019    Source:sciencedirect.com

Phenazocine is a unique opioid as it is a pure μ-agonist and is absorbed sublingually. It is similar to morphine and has a low incidence of sedation, nausea and vomiting and does not cause spasm of the sphincter of Oddi. We have performed an observational pilot study to evaluate the effectiveness of sublingual phenazocine for postoperative pain. Twenty patients were included. All patients were reviewed at 24 hours post surgery when a visual analogue pain score was recorded before and after phenazocine administration. Any side effects were also recorded. Eighteen out of twenty patients had a reduction in their pain score. The incidence of side effects was low, with one patient experiencing mild nausea, one mild vomiting, one mild hypotension and one moderate sedation. Eleven of the patients commented on the unpleasant taste. We have found sublingual phenazocine to be useful in the treatment of postoperative pain.

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