Research paperInteraction of amphotericin B with human and bovine serum albumins: A fluorescence polarization study

Add time:09/26/2019    Source:sciencedirect.com

In this study, the interaction of amphotericin B with human and bovine serum albumins has been investigated by fluorescence spectroscopy. Due to the limitations of several analytical methods by the known aggregation of amphotericin B molecules in aqueous solutions, fluorescence polarization technique was employed to determine complex stabilities. Besides the quantitation of reliable stability constants, this method was found to be able determine the stable aggregated amphotericin B fraction in the presence of serum albumins. Our results demonstrate the formation of highly stable albumin-drug complexes, suggesting the significant role of serum albumins regarding the plasma protein binding of amphotericin B.

We also recommend Trading Suppliers and Manufacturers of amphotericin A (cas 1405-32-9). Pls Click Website Link as below: cas 1405-32-9 suppliers

Prev:Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma
Next:Mini-reviewProbing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin (cas 1405-39-6) and aegerolysin proteins)