Asymmetric synthesis of both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl]ethanol

Add time:07/16/2019    Source:sciencedirect.com

SummaryBoth enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy)phenyl)ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most potent enantiomer was structurally characterized by X-ray crystallographic analysis.

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