The (+/-)-anti-dihydrodiol epoxides (DE) of benzo[a]pyrene (BP), chrysene (Chr), benzo[c]phenanthrene (BcPh) and dibenz[a,h]anthracene (DBA) were incubated in the presence of glutathione (GSH) with hepatic cytosol from untreated and Aroclor 1254 pretreated rats and with the Mu-class glutathione ...
Sulfur-containing polycyclic aromatic hydrocarbons (thia-PAHs or thiaarenes) are common constituents of air pollution and cigarette smoke, but only a few have been studied for health effects. We evaluated the mutagenicity in Salmonella TA98, TA100, and TA104 of two sulfur-containing derivatives ...
Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) ingested with food have repeatedly been suggested to be involved in the malignant transformation of colon epithelial cells. In order to test this hypothesis, HCEC cells (SV40 large T antigen-immortalized human colon ...
Carcinogenic activity of many polycyclic aromatic hydrocarbons (PAHs) is mainly attributed to their respective diol epoxides, which can be classified as either bay or fjord region depending upon the location of the epoxide function. The Pi class human glutathione (GSH) transferase (hGSTP1-1), wh...
A procedure for the synthesis of 8,16-imino-6H,14H-di-naphtho[2,1-b:2,1-f][1,5]dioxocin from the reaction of 2-hydroxy-1naphthaldehyde with ammonium acetate is described.
7-Substituted dinaphtho[2,1-b;1′,2′-d]-siloles 2 and -germoles 3, involving the first isolated example of optically active group 14 dinaphthoheteroles, have been prepared from 2,2′-dibromo-1,1′-binaphthyl (DBBN) via 2,2′-dilithio-1,1′-binaphthyl intermediate. They are fluxional in the NMR ...
Conjugated aromatic diene-diyne (3) undergoes thermal cyclization at 80 o C to form cyclobuta[a]naphthalene (4), leading to polycyclic compounds, dinaphtho[1,2-b:2,1-f]semibullvalene (5) and dinaphtho[2,1-b:1,2-j]elassovalene (7).
To gain a deeper insight into the potential interactions between individual aromatic hydrocarbons in a mixture, several benzo[a]pyrene (B[a]P) and 7H-dibenzo[c,g]carbazole (DBC) binary mixtures were studied. The biological activity of the binary mixtures was investigated in the HepG2 and WB-F344...
The formation and persistence of DNA adducts in liver, intestinal mucosa, gills and brain of juvenile northern pike (Esox lucius) following oral exposure to benzo[a]pyrene (BaP), benzo[k]fluoranthene (BkF) and 7H-dibenzo[c,g]carbazol (DBC) were analysed by 3 2 P-postlabelling. The do...
Dibenzo[c,g]carbazole is the first heterocyclic aromatic compound that is known to be activated by one-electron oxidation; the resulting radical cation intermediate reacts with DNA to form adducts. We synthesized reference DNA adducts and studied them by MALDI and PSD, as well as by four-sector...
A highly efficient and atom economical one‐pot annulation strategy for novel tetrahydrothiopyrano[3,4‐b]indoles is presented. This protocol involves a Bi(OTf)3 catalyzed tandem Friedel–Crafts alkylation and intramolecular thia‐Michael addition reactions to furnish target molecules in an effi...
The E-transformation is quadratic in the projective 2-dimensional space and based on the circle n2 and the center W, which lies on the circle n2 . In the E-transformation to the straight line a’ corresponds a conic a2. The elation has been defined, where a’ is a vanishing line, the line ta par...
Opracowano metodę oznaczania 3,4-dichloro- aniliny (DCA) w powietrzu na stanowiskach pracy z zastosowaniem wysokosprawnej chromatografii cieczowej (HPLC) z detektorem diodowym (DAD), która polega na: adsorpcji 3,4-dichloroaniliny na żelu krzemionkowym, ekstrakcji metanolem i analizie chromatogr...
Cyclopenta[cd]fluoranthene (1, acefluoranthylene) is obtained by Flash Vacuum Thermolysis of 3(1-chloroethenyl)fluorlanthene (4). The electronic properties (cyclic voltammetry , UV/Vis and fluorescence) of 1 are markedly affected by cyclopenta-fusion.
This study assessed the role of aryl hydrocarbon receptor (AHR) affinity, and cytochrome P4501A (CYP1A) protein and activity in polyaromatic hydrocarbon (PAH)-induced oxidative stress. In the 1–100nM concentration range benzo[a]pyrene (BaP) but not benzo[e]pyrene (BeP) competitively displaced 2...
We report zero kinetic energy (ZEKE) photoelectron spectroscopy via resonantly enhanced multiphoton ionization (REMPI) for benzo[e]pyrene. Extensive vibronic coupling between the first electronically excited state and a nearby state allows b 2 modes to be observed which would be Franck–...
New solid-matrix phosphorescence (SMP) methods for (±)-anti-DB[a,l]PDE-DNA adducts and B[e]P were developed. The methods can be used to detect and characterize (±)-anti-DB[a,l]PDE-DNA adducts and B[e]P by employing SMP spectra, intensities, and lifetimes acquired with the heavy-atom salt, TlNO...
Three blue materials based on diphenylamino dibenzo[g,p]chrysene were designed and synthesized via Buchwald-Hartwig amination. To characterize their electroluminescent properties, multilayered organic light emitting diodes (OLEDs) were fabricated with the following device structure: indium tin o...
One polycyclic aromatic hydrocarbon compound, 3,6,11,14-tetraphenyldibenzo[g,p]chrysene (TPDBC), was designed, synthesized, and fabricated in a red phosphorescent organic light-emitting diode (PHOLED) with a maximum external quantum efficiency (EQE) of 14.4%, which represented the first report o...
Carbon thin films were prepared from decacyclene on quartz substrates with a chemical vapor deposition (CVD) process at 900°C under various conditions. The thickness and the electrical conductivity of these carbon thin films were measured by analytical instruments. As a result, it was found t...