ortho‐Oxo substituted trans 2,3‐diaryloxiranes were regio‐ and stereoselectively arylated by arylzinc reagents, obtained from the corresponding boronic acids by B–Zn exchange. The reaction was quite general, irrespective to the aryl nucleophile and proceeded via a ring opening at the α‐car...
W artykule prezentowane są nowe propozycje krytyczno-literackie i egzegetyczne odnośnie interpretacji Rdz 1,1–2,3. Autor ze swej strony proponuje powiązanie ich ze sobą i stawia w związku z tym pytanie o możliwość nowego spojrzenia na interpretację tej perykopy. Spojrzenie na Rdz 1 z uwzględnie...
A novel and non-polymeric anion-inserting electrode material has been designed and prepared for promoting research on molecular ion rechargeable batteries: 5,12-diaminorubicene (DARb). The apolar core structure of a rubicene molecule has been coupled to two amino-groups for producing an original...
Carbon‐based materials, such as acenes, fullerenes, and graphene nanoribbons, are viewed as the potential successors to silicon in the next generation of electronics. Although a number of methodologies provide access to these materials’ all‐carbon variants, relatively fewer strategies readily...
Spectral and ion binding properties of the new synthesized benzo-15-crown-5 rubicene dye (Rubi-B15C5) have been investigated by the steady-state fluorescence spectroscopy. Since the new compound possesses a benzo-15-crown-5 ionophore unit, the complexation ability of the dye towards alkali metal...
The kinetics of the conjugation of carcinogenicanti-diol epoxides of chrysene (anti-CDE) and benzo(g)chrysene [anti-B(g)CDE] with glutathione (GSH) catalyzed by GSHS-transferase (GST) isoenzymes mGSTP1-1, mGSTM1-1, mGSTA3-3, mGSTA4-4, and GST 9.5 of female A/J mouse tissues has been investigated...
Efficient enantioselective syntheses of both enantiomers of the title compound are achieved (>99% ee) via asymmetric dihydroxylation of a stilbene-type precursor using Sharpless catalysts followed by intramolecular biaryl coupling with Pd(PPh 3 ) 2 Cl 2 . This is the fir...
The solution structure of the adduct derived from the covalent bonding of the fjord region (+)-(11S, 12R, 13R, 14S) stereoisomer of anti-11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrobenzo[g]chrysene, (+)-anti-B[g]CDE, to the exocyclic N6 amino group of the adenine residue dA6, (designated (...
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants that have been linked to certain human cancers. The fjord region PAH dibenzo[a,l]pyrene exhibits the highest levels of carcinogenic activity of all PAH as yet tested in rodent tumor models. Another hexacyclic aromati...
The synthesis and spectroscopic properties of a series of new organic electron donors derived from dibenzo[2,3:5,6]pyrrolizino-[1,7-bc]indolo[1,2,3-lm]carbazole are described. These compounds can be considered as planar hybrids of carbazole and p-phenylenediamine and possess high thermal stabili...
Cyclosporin A sensitive swelling of mitochondria isolated from control mouse livers and from the livers of transgenic mice expressing human ubiquitous mitochondrial creatine kinase occurred in the presence of both 40 μM calcium and 5 μM atractyloside which was accompanied by a 2.5-fold increas...
Creatine is a popular ergogenic supplement in sports nutrition. Yet, supplementation of creatine occasionally caused adverse effects such as gastrointestinal complaints, muscle cramps and an increase in body weight. Creatine monohydrate has already been evaluated by different competent authoriti...
Homocystinuria is a neurometabolic disease caused by a severe deficiency of cystathionine beta‐synthase activity, resulting in severe hyperhomocysteinemia. Affected patients present several symptoms including a variable degree of motor dysfunction. In this study, we investigated the effect of c...
The assembly of disk-shaped molecules on surfaces has drawn considerable attention because of their unique electronic and optical properties. We have studied the monolayer of the amphiphilic tricycloquinazoline (AmTCQ) based disk-shaped molecules at the air–water and air–solid interfaces. The ...
The nonlinear absorption was studied for compounds linking tricycloquinazoline to a number of iridium groups. It was determined that the excited-state cross section was highest for the compound with a single iridium group.
Self-assembled monolayers (SAMs) of hexaalkylthioether derivatives of tricycloquinazoline (TCQ) on Au(111) and tungsten diselenide (WSe 2 ) were investigated by scanning tunneling microscopy (STM). The Au(111) surfaces were found to be etched by the thioether containing solutions. Corrod...
A series of 5-substituted 2-amino-4,6-dihydroxypyrimidines were prepared by a modified condensation of the corresponding monosubstituted malonic acid diesters with guanidine in an excess of sodium ethoxide. The optimized procedure using Vilsmeier–Haack–Arnold reagent, followed by immediate dep...
A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(PPh 3 ) 2 Cl 2 as catalyst. The same reaction was applied to 2-amino-4,6...
The self-assembly reaction of 4-hydroxy-2-mercapto-6-methylpyrimidine, KOH and di-n-butyltin dichloride in CH 3 OH and H 2 O (V/V=1:1) under solvothermal conditions (150°C) affords a novel one-dimensional infinite polymeric chain complex 1, which involves high centrosymmetric un...
The nucleophilic substitution of halogen (chlorine, bromine, and iodine) in alkyl and benzyl halides has been effected in aqueous dioxane media with S-and O-anions generated from 4-hydroxy-2-mercapto-6-methylpyrimidine. Under these conditions replacement of halogen proceeds by an SN2 mechanism a...