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4-benzyloxycarbonylaminobutyric acid 2-methoxyethyl ester
A
2-methoxy-ethanol
B
4-(benzyloxycarbonylamino)butyric acid
Conditions | Yield |
---|---|
With methanol; Bacillus subtilis esterase In hexane at 37℃; for 0.5h; pH=7.4; Kinetics; Reagent/catalyst; Time; aq. phosphate buffer; Enzymatic reaction; | A n/a B 100% |
Conditions | Yield |
---|---|
With trans-RuCl2(PPh3)[PyCH2NH(CH2)2PPh2]; potassium tert-butylate; hydrogen In tetrahydrofuran at 40℃; under 37503.8 Torr; for 16h; | 100% |
With hydrogen; sodium methylate; [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II) In methanol at 80℃; under 37503.8 Torr; for 8h; | |
With ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); potassium methanolate; hydrogen In tetrahydrofuran at 60℃; under 37503.8 Torr; for 16h; Glovebox; Inert atmosphere; | |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 38002.6 Torr; for 4h; Autoclave; | 99 %Chromat. |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 25℃; under 37503.8 Torr; for 4h; | 99 %Spectr. |
Conditions | Yield |
---|---|
With bentonite clay at 50℃; for 18h; Product distribution; other oxides and reactions partners; var. temperatures and amounts of reaction partners; | 98.1% |
With sulfuric acid | |
With boron trifluoride diethyl etherate at -10℃; |
Conditions | Yield |
---|---|
With methanol at 20℃; for 0.5h; | 97% |
Conditions | Yield |
---|---|
With iron(III) perchlorate at 20℃; for 1.5h; neat (no solvent); | 88% |
oxirane
Tetraethylene glycol dimethyl ether
carbon monoxide
A
2-methoxy-ethanol
B
methyl ester (3-hydroxy) propionic acid
C
methyl β-(β-hydroxypropionyloxy)propionate
D
acetaldehyde
Conditions | Yield |
---|---|
3-HYDROXYPYRIDINE; dicobalt octacarbonyl at 75℃; under 45004.5 Torr; for 4h; Heating / reflux; | A n/a B 81.08% C n/a D n/a |
Conditions | Yield |
---|---|
With ruthenium-carbon composite; hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Autoclave; Sealed tube; | 81% |
Conditions | Yield |
---|---|
With trans-[(2,6-bis(di-tert-butylphosphinomethyl)pyridine)Fe(H)2(CO)]; hydrogen; sodium methylate In 1,4-dioxane at 40℃; under 18751.9 Torr; for 16h; Glovebox; Inert atmosphere; | A n/a B 80% |
Conditions | Yield |
---|---|
With sodium ethanolate at 78℃; for 1h; | 78% |
Conditions | Yield |
---|---|
With bis(acetylacetonate)oxovanadium; methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate at 120℃; for 48h; | A 76% B 78% |
The IUPAC name of Ethylene glycol methyl ether is 2-methoxyethanol. With the CAS registry number 109-86-4, it is also named as Methyl cellosolve. The product's categories are Industrial/Fine Chemicals; Ethylene Glycols & Monofunctional Ethylene Glycols; Monofunctional Ethylene Glycols; Two-component reagents; Amber Glass Bottles; Blends- Chromasolv LC-Mschromasolv Solvents (HPLC, LC-MS); Chromasolv Solvents (HPLC, LC-MS); Chromasolv(R) LC-MSSpectroscopy; LC-MS BlendsSolvents; LC-MS Plus and Gradient; Pre-Blended Mobile Phase Solvents; Solvent Bottles; Water and Water Solutions. Besides, it is clear colorless liquid, which should be stored in a cool, ventilated warehouse at 5 °C. The chemical is stable, but contact with air may lead to the formation of explosive peroxides. In addition, its molecular formula is C3H8O2 and molecular weight is 76.09.
The other characteristics of this product can be summarized as: (1)EINECS: 203-713-7; (2)ACD/LogP: -0.80; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -0.8; (5)ACD/LogD (pH 7.4): -0.8; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 8.77; (9)ACD/KOC (pH 7.4): 8.77; (10)#H bond acceptors: 2; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 3; (13)Index of Refraction: 1.385; (14)Molar Refractivity: 19.22 cm3; (15)Molar Volume: 81.9 cm3; (16)Surface Tension: 27.6 dyne/cm; (17)Density: 0.928 g/cm3; (18)Flash Point: 46.1 °C; (19)Melting Point: -85 °C; (20)Water Solubility: 1.00E+06 mg/L at 25 °C; (21)Enthalpy of Vaporization: 37.54 kJ/mol; (22)Boiling Point: 124.4 °C at 760 mmHg; (23)Vapour Pressure: 5.98 mmHg at 25 °C.
Preparation of Ethylene glycol methyl ether: this chemical can be prepared by the reaction of Ethylene oxide with Methanol.
This reaction will occur at high temperature and pressure.
Uses of Ethylene glycol methyl ether: this chemical is the intermediate of cinosulfuron. It is also a solvent of fats and oils nitro cellulose and synthetic resin. And it can be used as as paint solvent, penetrant, leveling agent. Moreover, it is used as an intermediate in organic synthesis. The product is used as an additive of jet fuel. Additionally, it can be used for the determination of iron, sulfate and Carbon disulfide.
When you are using this chemical, please be cautious about it as the following: it is highly flammable that may cause severe burns.Please keep away from sources of ignition. It is also harmful by inhalation, in contact with skin and if swallowed. And it is toxic by inhalation, in contact with skin and if swallowed. Please do not breathe vapour. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Furthermore, you should wear suitable protective clothing and gloves. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible). What's more, it is danger of very serious irreversible effects that may cause harm to the unborn child. Similarly, it may impair fertility. You should avoid exposure - obtain special instructions before use.
People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: COCCO
(2)InChI: InChI=1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
(3)InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 950mg/kg (950mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. |
human | LDLo | oral | 3380mg/kg (3380mg/kg) | GASTROINTESTINAL: GASTRITIS LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 267, 1946. |
human | TCLo | inhalation | 25ppm (25ppm) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Journal of Industrial Hygiene and Toxicology. Vol. 20, Pg. 134, 1938. |
mouse | LC50 | inhalation | 1480ppm/7H (1480ppm) | BEHAVIORAL: ANALGESIA KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943. |
mouse | LD50 | intraperitoneal | 2147mg/kg (2147mg/kg) | KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN BLOOD: OTHER CHANGES | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
mouse | LD50 | oral | 2560mg/kg (2560mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988. |
rabbit | LD50 | oral | 890mg/kg (890mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA | AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956. |
rabbit | LD50 | skin | 1280mg/kg (1280mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974. | |
rat | LC50 | inhalation | 1500ppm/7H (1500ppm) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974. | |
rat | LD50 | intraperitoneal | 2500mg/kg (2500mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974. | |
rat | LD50 | intravenous | 2068mg/kg (2068mg/kg) | BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA | AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956. |
rat | LD50 | oral | 2370mg/kg (2370mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Veterinary and Human Toxicology. Vol. 29, Pg. 361, 1987. |