Piperazine

Molecule structure of Piperazine (CAS NO.110-85-0):

IUPAC Name: Piperazine 
Molecular Weight: 86.1356 g/mol
Molecular Formula: C₄H₁₀N₂ 
Density: 0.874 g/cm³ 
Boiling Point: 149.3 °C at 760 mmHg 
Flash Point: 49.7 °C
Index of Refraction: 1.424
Molar Refractivity: 25.14 cm³
Molar Volume: 98.5 cm³
Surface Tension: 27.5 dyne/cm
Enthalpy of Vaporization: 38.62 kJ/mol
Vapour Pressure: 4.05 mmHg at 25 °C
XLogP3: -1.5
H-Bond Donor: 2
H-Bond Acceptor: 2
Exact Mass: 86.084398
MonoIsotopic Mass: 86.084398
Topological Polar Surface Area: 24.1
Heavy Atom Count: 6
Canonical SMILES: C1CNCCN1
InChI: InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
InChIKey: GLUUGHFHXGJENI-UHFFFAOYSA-N
EINECS: 203-808-3
Product Categories: blocks; BuildingBlocks; Organics

 Piperazine (CAS NO.110-85-0) is commonly used as a pharmaceutical intermediate, and mainly used in the preparation of piperazine phosphours, fluphenazine and Rifandin,etc. It's also used for production of wetting agent, emulsifier, dispersant, antioxidant, etc.

Reported in EPA TSCA Inventory.

Hazard Codes: C
Risk Statements: 34-42/43-52/53 
R34:Causes burns. 
R42/43:May cause sensitization by inhalation and skin contact. 
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 22-26-36/37/39-45-61 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2579 8/PG 3
WGK Germany: 1
RTECS: TK7800000
F: 3-8-23
Hazard Note: Harmful/Corrosive
HazardClass: 8
PackingGroup: III
Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NO_x.

DOT Classification:  8; Label: Corrosive

 Piperazine (CAS NO.110-85-0) is also named as 1,4-Diazacyclohexane ; 1,4-Diethylenediamine ; 1,4-Piperazine ; 5-23-01-00030 (Beilstein Handbook Reference) ; Antiren ; Asca-Trol No. 3 ; BRN 0102555 ; CCRIS 5950 ; Diethylenediamine ; Diethyleneimine ; Dispermine ; Entacyl ; Eraverm ; Eraverm (VAN) ; HSDB 1093 ; Hexahydro-1,4-diazine ; Hexahydropyrazine ; Lumbrical ; NSC 474 ; Piperazidine ; Piperazin ; Piperazin [German] ; Piperazine, anhydrous ; Pipersol ; Pyrazine hexahydride ; Pyrazine, hexahydro- ; UNII-1RTM4PAL0V ; Uvilon ; Vermex ; Worm-A-Ton ; Wurmirazin . Piperazine (CAS NO.110-85-0) is needle-like white or colorless crystals. It is very corrosive to skin, eyes and mucous membranes. Solid of Piperazine turns dark when exposed to light. It is flammable and soluble in water. Piperazine  neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. It may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.