Products Categories
| CAS No.: | 107-06-2 |
|---|---|
| Name: | 1,2-Dichloroethane |
| Molecular Structure: | |
|
|
|
| Formula: | C2H4Cl2 |
| Molecular Weight: | 98.9598 |
| Synonyms: | 1,2-Bichloroethane;1,2-Dichlorethane;1,2-Ethylene dichloride;Brocide;DCE;Dichlor-Mulsion;Dutch liquid;EDC;EDC (halocarbon);Ethylene chloride;Ethylene dichloride;Glycol dichloride;HCC 150;sym-Dichloroethane;a,b-Dichloroethane;1,2-Dichloroethane; |
| EINECS: | 203-458-1 |
| Density: | 1.173 g/cm3 |
| Melting Point: | -35 °C |
| Boiling Point: | 83.5 °C at 760 mmHg |
| Flash Point: | 15.6 °C |
| Solubility: | 8.7 g/L (20℃) |
| Appearance: | clear liquid |
| Hazard Symbols: |
 F, T
|
| Risk Codes: | 45-11-22-36/37/38-23/25 |
| Safety: | 53-45-24-16-7 |
| Transport Information: | UN 1184 3/PG 2 |
| PSA: | 0.00000 |
| LogP: | 1.46400 |
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- 75-21-8
oxirane
- 5003-97-4
trichlorodistyrylphosphorane
A
- 139888-58-7
Bis-((E)-styryl)-phosphinic acid 2-chloro-ethyl ester
B
- 107-06-2
1,2-dichloro-ethane
| Conditions | Yield |
|---|---|
| With titanium tetrachloride In benzene at 40℃; | A 91% B n/a |
- 75-21-8
oxirane
- 4895-49-2, 40851-17-0
Styryl-phosphortetrachlorid
A
- 39229-97-5
bis(2-chloroethyl) styrylphosphonate
B
- 107-06-2
1,2-dichloro-ethane
| Conditions | Yield |
|---|---|
| With titanium tetrachloride In benzene at 40℃; | A 90% B n/a |
| Conditions | Yield |
|---|---|
| With chlorotrifluoromethane; hydrogen iodide Product distribution; Mechanism; Irradiation; var. pressure; labeling (38)Cl; | A 0.76% B 78% |
- 74-85-1
ethene
- 7182-86-7
tetrabutylammonium p-toluenesulfonate
A
- 80-41-1
2-chloroethyl tosylate
B
- 107-06-2
1,2-dichloro-ethane
| Conditions | Yield |
|---|---|
| With chlorine In dichloromethane at 20℃; for 0.25h; Product distribution; Mechanism; | A 43% B 57 % Spectr. |
| With chlorine In dichloromethane at 20℃; for 0.25h; | A 43% B 57 % Spectr. |
| With chlorine In dichloromethane Ambient temperature; |
| Conditions | Yield |
|---|---|
| With tetrabutylammonium p-toluenesulfonate; chlorine In dichloromethane at 20℃; for 0.25h; | A 43% B 57 % Spectr. |
- 75-09-2
dichloromethane
- 62-53-3
aniline
A
- 100-62-9
N-methylenebenzenamine
B
- 74-87-3
methylene chloride
C
- 107-06-2
1,2-dichloro-ethane
D
- 1227476-15-4
Azobenzene
E
- 101-54-2
N-phenylphenylene-1,4-diamine
F
- 534-85-0
N-phenyl-1,2-benzenediamine
| Conditions | Yield |
|---|---|
| at 15℃; for 24h; Product distribution; Mechanism; Irradiation; | A n/a B n/a C n/a D 18.6% E 15.6% F 25.8% G n/a |
- 18407-40-4
chloromethyl-methyl-diphenyl-silane
A
- 75-79-6
Methyltrichlorosilane
B
- 92-52-4
biphenyl
C
- 144-79-6
chloromethyldiphenylsilane
D
- 98-13-5
Phenyltrichlorosilane
E
- 107-06-2
1,2-dichloro-ethane
| Conditions | Yield |
|---|---|
| iron(III) chloride at 70℃; for 0.5h; Product distribution; other conditions: other catalyst, other temperature; | A 8% B 10% C 17% D 14% E 22% |
- 177-10-6
1,3-dioxolane-2-spirocyclohexane
A
- 22354-42-3
6-(1-cyclohexenyl)caproic acid β-chloroethyl ester
B
- 107-21-1
ethylene glycol
C
- 107-06-2
1,2-dichloro-ethane
D
- 107-07-3
2-chloro-ethanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 150℃; for 2h; | A 15% B n/a C n/a D n/a |
- 176-32-9
1,4-dioxaspiro[4.4]nonane
A
- 23182-13-0
5-(1-cyclopentenyl)valeric acid β-chloroethyl ester
B
- 107-21-1
ethylene glycol
C
- 107-06-2
1,2-dichloro-ethane
D
- 107-07-3
2-chloro-ethanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride at 150℃; for 2h; | A 14% B n/a C n/a D n/a |
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- 141-53-7Sodium formate
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- 9003-39-8Povidone
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- 402957-28-2Telaprevir
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- Total:27 Page 1 of 1 1
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History
In 1794, a group of four Dutch friends under the name of Gezelschap der Hollandsche Scheikundigen consisted of physician Jan Rudolph Deiman, merchant Adriaan Paets van Troostwijk, chemist Anthoni Lauwerenburg and botanist Nicolaas Bondt. They were the first to produce 1,2-dichloroethane(107-06-2) from olefiant gas and chlorine gas. Although the Gezelschap in practice didn't do much in-depth scientific research, they and their publications were highly regarded. Part of that acknowledgement is that 1,2-dichloroethane(107-06-2) has been called Dutch oil in old chemistry.
Specification
The 1,2-Dichloroethane is an organic compound with the formula C2H4Cl2. The IUPAC name of this chemical is 1,2-dichloroethane. With the CAS registry number 107-06-2, it is also named as 1,2-Ethylidene dichloride. The product's categories are Refrigerants; Organics; alpha,omega-Bifunctional Alkanes; alpha,omega-Dichloroalkanes; Analytical Chemistry; Monofunctional & alpha,omega-Bifunctional Alkanes; Solvents for HPLC & Spectrophotometry; Solvents for Spectrophotometry; Alpha Sort; D; DAlphabetic; DIA - DIC; Volatiles/Semivolatiles. Besides, it is clear liquid, which should be stored in a cool and well-ventilated place.
Physical properties about 1,2-Dichloroethane are:
(1)ACD/LogP: 1.41; (2)ACD/LogD (pH 5.5): 1.41; (3)ACD/LogD (pH 7.4): 1.41; (4)ACD/BCF (pH 5.5): 6.99; (5)ACD/BCF (pH 7.4): 6.99; (6)ACD/KOC (pH 5.5): 139.95; (7)ACD/KOC (pH 7.4): 139.95; (8)#Freely Rotating Bonds: 1; (9)Index of Refraction: 1.412; (10)Molar Refractivity: 21.01 cm3; (11)Molar Volume: 84.3 cm3; (12)Polarizability: 8.33×10-24cm3; (13)Surface Tension: 25 dyne/cm; (14)Density: 1.173 g/cm3; (15)Flash Point: 15.6 °C; (16)Enthalpy of Vaporization: 31.98 kJ/mol; (17)Boiling Point: 83.5 °C at 760 mmHg; (18)Vapour Pressure: 83.9 mmHg at 25°C.
Preparation of 1,2-Dichloroethane:
Production is primarily achieved through the iron(III) chloride-catalysed reaction of ethene (ethylene) and chlorine.
H2C=CH2 + Cl2 → ClCH2-CH2Cl
1,2-dichloroethane is also generated by the copper(II) chloride-catalysed "oxychlorination" of ethylene:
H2C=CH2 + 2 HCl + ½ O2 → ClCH2-CH2Cl + H2O
In principle, it can be prepared by the chlorination of ethane and, less directly, from ethanol.
Uses of 1,2-Dichloroethane:
with approximately 80% of the world's consumption of 1,2-dichloroethane, the major use of 1,2-dichloroethane is in the production of vinyl chloride monomer (VCM, chloroethene) with hydrogen chloride as a byproduct. VCM is the precursor to polyvinyl chloride.
Cl-CH2-CH2-Cl → H2C=CH-Cl + HCl
The hydrogen chloride can be re-used in the production of more 1,2-dichloroethane via the oxychlorination route described above.
When you are using 1,2-Dichloroethane, please be cautious about it as the following:
It is highly flammable and harmful if swallowed. It is toxic by inhalation and if swallowed. Please keep container tightly closed and keep away from sources of ignition - No smoking. Besides, this chemical is irritating to eyes, respiratory system and skin and may cause cancer. When you are using it, do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C(CCl)Cl
(2)InChI: InChI=1S/C2H4Cl2/c3-1-2-4/h1-2H2
(3)InChIKey: WSLDOOZREJYCGB-UHFFFAOYSA-N
The toxicity data of 1,2-Dichloroethane is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LC | inhalation | > 3000ppm/7H (3000ppm) | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. | |
| dog | LD50 | oral | 5700mg/kg (5700mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970. |
| dog | LDLo | intravenous | 175mg/kg (175mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| guinea pig | LCLo | inhalation | 1500ppm/7H (1500ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. |
| guinea pig | LDLo | intraperitoneal | 600mg/kg (600mg/kg) | American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974. | |
| human | LDLo | oral | 286mg/kg (286mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: FATTY LIVER DEGERATION | Casopis Lekaru Ceskych. Journal of Czech Physicians. Vol. 86, Pg. 203, 1947. |
| human | TDLo | oral | 428mg/kg (428mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: COUGH GASTROINTESTINAL: NAUSEA OR VOMITING | Sovetskaia Meditsina. Vol. 22(10), Pg. 132, 1958. |
| mammal (species unspecified) | LC | inhalation | > 3000ppm/7H (3000ppm) | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. | |
| man | LDLo | oral | 714mg/kg (714mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Klinische Wochenscrift. Vol. 48, Pg. 822, 1970. |
| man | TCLo | inhalation | 4000ppm/1H (4000ppm) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 500, 1966. |
| man | TDLo | oral | 892mg/kg (892mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" | Wiadomosci Lekarskie. Medical News. Vol. 28, Pg. 983, 1975. |
| monkey | LC50 | inhalation | 3000ppm/7H (3000ppm) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 93, 1986. | |
| mouse | LCLo | inhalation | 5gm/m3/2H (5000mg/m3) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 141, Pg. 19, 1929. | |
| mouse | LD50 | intraperitoneal | 470mg/kg (470mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 902, 1961. | |
| mouse | LD50 | oral | 413mg/kg (413mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES | EHP, Environmental Health Perspectives. Vol. 43, Pg. 41, 1982. |
| mouse | LDLo | subcutaneous | 380mg/kg (380mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. | |
| pig | LCLo | inhalation | 3000ppm/7H (3000ppm) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. |
| rabbit | LCLo | inhalation | 3000ppm/7H (3000ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 53, 1945. |
| rabbit | LD50 | oral | 860mg/kg (860mg/kg) | Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 264, 1973. | |
| rabbit | LD50 | skin | 2800mg/kg (2800mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: GENERAL ANESTHETIC | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970. |
| rabbit | LDLo | subcutaneous | 1200mg/kg (1200mg/kg) | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| rat | LC50 | inhalation | 1000ppm/7H (1000ppm) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 482, 1951. |
| rat | LD50 | intraperitoneal | 807mg/kg (807mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(4), Pg. 26, 1982. | |
| rat | LD50 | oral | 670mg/kg (670mg/kg) | Farm Chemicals Handbook. Vol. -, Pg. C130, 1991. | |
| rat | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA | FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 91, 1970. |
| rat | LDLo | intratracheal | 120mg/kg (120mg/kg) | National Technical Information Service. Vol. OTS0520615, |