Related Products
- 3-Cyanopyridine
- 3-Cyanopyridine N-oxide
- 3-Cyanopyridine-2-carboxylic acid
- 3-Cyanopyridine-4-boronic acid
- 3-Cyanopyridine-4-boronic acid pinacol ester
- 100-55-0Nicotinyl alcohol
- 100553-83-11-(4-Fluorophenyl)-3-methyl-2-pyrazolin-5-one
- 100556-58-98-exo-Iodo-2-azabicyclo[3.3.0]octan-3-one
- 1005-56-7Carbonochloridothioicacid, O-phenyl ester
- 100557-22-01H-Indol-4-amine,1-(phenylsulfonyl)-
- 100558-60-9trans-4-ethylcyclohexylbenzene
- 100-56-1Mercury, chlorophenyl-
- 100563-34-63H-1,2,4-Triazol-3-one, 2-(2,4-dichloro-5-nitrophenyl)-1,2-dihydro-5-methyl-
- 100563-50-63H-1,2,4-Triazol-3-one, 2-(4-bromo-2-fluoro-5-nitrophenyl)-1,2-dihydro-5-methyl-
- 1005-63-6Benzenamine,4-(ethenyloxy)-
Hot Products
- 1501-84-4Tricyclo[3.3.1.13,7]decane-1-methanamine,a-methyl-, hydrochloride (1:1)
- 15676-16-1Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-
- 75-45-6Methane,chlorodifluoro-
- 5308-25-81-Ethylpiperazine
- 793-24-81,4-Benzenediamine,N1-(1,3-dimethylbutyl)-N4-phenyl-
- 333-20-0Potassium thiocyanate
- 14047-28-09H-Purine-9-ethanol,6-amino-a-methyl-, (aR)-
- 110-65-62-Butyne-1,4-diol
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
3-Cyanopyridine |
EINECS | 202-863-0 |
| CAS No. | 100-54-9 | Density | 1.159 g/cm3 |
| PSA | 36.68000 | LogP | 0.95328 |
| Solubility | 140 g/L (20 °C) in water | Melting Point |
48-52 °C(lit.) |
| Formula | C6H4N2 | Boiling Point | 202.985 °C at 760 mmHg |
| Molecular Weight | 104.111 | Flash Point | 84.444 °C |
| Transport Information | N/A | Appearance | white to beige solid |
| Safety | 22-24/25-36/37/39-26 | Risk Codes | 22-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Nicotinonitrile(8CI);3-Azabenzonitrile;3-Pyridinenitrile;3-Pyridylcyanide;3-Pyridylcarbonitrile;NSC 17558;Nicotinic acid nitrile;b-Cyanopyridine;3-Pyridinecarbonitrile; |
Article Data | 362 |
3-Cyanopyridine Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide; copper(l) chloride In toluene at 100℃; for 24h; | 99% |
| With 3 A molecular sieve at 150 - 500℃; under 0.001 Torr; for 0.666667h; Pyrolysis; | 98% |
| With oxalyl dichloride; triethylamine; Triphenylphosphine oxide In acetonitrile at 20℃; for 0.166667h; | 96% |
Conditions
| Conditions | Yield |
|---|---|
| With ammonium sulfate; sodium carbonate; sulfur In dimethyl sulfoxide at 120℃; for 10h; Sealed tube; | 99% |
| With ammonia; oxygen In ethanol; water for 1.5h; Reflux; | 94% |
| With hydroxylamine hydrochloride; pyrographite; methanesulfonyl chloride at 100℃; for 1h; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-hydroxymethylpyridin With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tert-butylhypochlorite In dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: With ammonia; iodine In dichloromethane; water at 20℃; for 2h; Inert atmosphere; | 99% |
| With ammonia; oxygen In tert-Amyl alcohol; water at 100℃; under 3750.38 Torr; for 4h; Autoclave; High pressure; | 99% |
| With potassium phosphate; ammonium formate In acetonitrile at 115℃; for 16h; Sealed tube; Green chemistry; | 91% |
Conditions
| Conditions | Yield |
|---|---|
| With C18H14CuIN4 In acetonitrile at 20℃; for 24h; Inert atmosphere; Sealed tube; UV-irradiation; | 99% |
Conditions
| Conditions | Yield |
|---|---|
| With manganese; ammonia; oxygen; pyrographite at 335℃; Temperature; | 98.7% |
| With ammonia In water at 200 - 300℃; Concentration; | 97% |
| With aluminum oxide; ammonia; oxygen at 300℃; Concentration; Temperature; | 93.1% |
Conditions
| Conditions | Yield |
|---|---|
| With Palladium Nanoparticles with two shape-persistent covalent cages CC1' In N,N-dimethyl-formamide at 140℃; for 15h; Reagent/catalyst; Inert atmosphere; | 98% |
Conditions
| Conditions | Yield |
|---|---|
| With tellurium tetrachloride; triethylamine In chloroform for 3h; Ambient temperature; | 96% |
| With methylene blue; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; Sealed tube; Irradiation; | 95% |
| With bis(tri-n-butyltin)oxide In benzene for 0.5h; Heating; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| With thionyl chloride; polyvinylpyrrolidone In dichloromethane at 20℃; for 0.25h; Dehydration; | 95% |
| With 1,4-diaza-bicyclo[2.2.2]octane; trichlorophosphate In dichloromethane at 20℃; for 0.0833333h; | 94% |
| With aluminium trichloride; sodium iodide In acetonitrile for 2.5h; Heating; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| With tributyltin chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium (0) In acetonitrile at 22℃; for 3h; | 95% |
Conditions
| Conditions | Yield |
|---|---|
| With sodium carbonate; palladium diacetate In 1-methyl-pyrrolidin-2-one; Hexadecane at 160℃; for 16h; | 95% |
| With sodium carbonate; cyclopalladated ferrocenylimine tricyclohexylphosphine In 1-methyl-pyrrolidin-2-one at 140℃; for 18h; | 82% |
| With sodium carbonate In N,N-dimethyl-formamide at 120℃; for 16h; | 57% |
| With tetra(adamantyl)biphosphine; palladium diacetate; sodium carbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 16h; Inert atmosphere; | 66 %Chromat. |
3-Cyanopyridine Chemical Properties
Nicotinonitrile(100-54-9) exists as white to off-white crystalline powder, insoluble in water, soluble in ethanol, benzene and other organic solvents.
Molecular Structure:
Molecular Formula: C6H4N2.
Molecular Weight: 104.11.
Density: 1.159.
Melting Point: 49 - 50 ℃.
Boiling Point: 202 ℃.
Flash Point: 85 ℃.
Solubility: 140 g/L (20℃).
Molecular Structure:
Molecular Formula: C6H4N2.
Molecular Weight: 104.11.
Density: 1.159.
Melting Point: 49 - 50 ℃.
Boiling Point: 202 ℃.
Flash Point: 85 ℃.
Solubility: 140 g/L (20℃).
3-Cyanopyridine Uses
Nicotinonitrile(100-54-9) is used as the intermediates of rodenticides in organic synthesis. Besides, Nicotinonitrile(100-54-9) is the intermediates of medicines, dyes, fodders, resins and so on.
3-Cyanopyridine Toxicity Data With Reference
| 1. | orl-rat LD50:1185 mg/kg | MEPAAX Medycyna Pracy. Industrial Medicine. 30 (1979),109. | ||
| 2. | ipr-mus LD25:810 mg/kg | JPMSAE Journal of Pharmaceutical Sciences. 64 (1975),528. | ||
| 3. | skn-rbt LDLo:4000 mg/kg | MEPAAX Medycyna Pracy. Industrial Medicine. 30 (1979),109. |
3-Cyanopyridine Consensus Reports
Reported in EPA TSCA Inventory.
3-Cyanopyridine Safety Profile
Moderately toxic by ingestion, intraperitoneal, and skin contact routes. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes:
Xn
Risk Statements: 22-36/37/38
22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-36/37/39-26
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
RTECS: QT3030000
HS Code: 29333999
Hazard Codes:
Xn Risk Statements: 22-36/37/38
22: Harmful if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-36/37/39-26
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
RTECS: QT3030000
HS Code: 29333999
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 100-54-9
3-Cyanopyridine
