- Enzyme-Catalyzed Organic Synthesis: Electrochemical Regeneration of NAD(P)H from NAD(P) Using Methyl Viologen and Flavoenzymes
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A procedure for enzyme-catalyzed organic synthesis is described in which regeneration of NAD(P)H from NAD(P) is accomplished by the electrochemical reduction of oxidized to reduced methyl viologen (MV2+ --> MV1+) followed by flavoenzyme-catalyzed reduction of the nicotinamide cofactor by this MV+1 (Scheme I).
- DiCosimo, Robert,Wong, Chi-Huey,Daniels, Lacy,Whitesides, George M.
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- CAGED COMPOUND, AND MANUFACTURING METHOD AND EXPRESSION METHOD OF CAGED COMPOUND
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PROBLEM TO BE SOLVED: To provide a caged compound excellent in light reactivity and dark place stability, and capable of deprotection by a visible light. SOLUTION: A caged compound is represented by the following general formula (1). In the general formula (1), R1 represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cyano group, an alkoxy group, a hydroxy group, or an alkylamino group, R2 represents an alkyl group or a hetero atom other than a nitrogen atom, R3 represents a hydrogen atom, a halogen atom or an alkyl group, X represents a monovalent anion, Y represents a monovalent organic group, Z represents a hydrogen atom or a monovalent organic group, and a represents 0 or 1, however a represents 0 when R2 represents the hetero atom other than the nitrogen atom. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
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Paragraph 0166; 0167
(2019/03/01)
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- Silicon nanowire photocathodes for light-driven electroenzymatic synthesis
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The photoelectroenzymatic synthesis of chemical compounds employing platinum nanoparticle-decorated silicon nanowires (Pt-SiNWs) is presented. The Pt-SiNWs proved to be an efficient material for photoelectrochemical cofactor regeneration because the silicon nanowires absorbs a wide range of the solar spectrum while the platinum nanoparticle serve as an excellent catalyst for electron and proton transfer. By integrating the platform with redox enzymatic reaction, visible-light-driven electroenzymatic synthesis of L-glutamate was achieved. Compared to electrochemical and photochemical methods, this approach is free from side reactions caused by sacrificial electron donors and has the advantage of applying low potential to realize energy-efficient and sustainable synthesis of chemicals by a photoelectroenzymatic system.
- Lee, Sahng Ha,Ryu, Gyeong Min,Nam, Dong Heon,Kim, Jae Hong,Park, Chan Beum
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p. 3007 - 3011
(2015/09/28)
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- Process for chemical reaction of amino acids and amides yielding selective conversion products
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The invention relates to processes for converting amino acids and amides to desirable conversion products including pyrrolidines, pyrrolidinones, and other N-substituted products. L-glutamic acid and L-pyroglutamic acid provide general reaction pathways to numerous and valuable selective conversion products with varied potential industrial uses.
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