187242-85-9

Basic information

• Product Name: (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one
• Synonyms: (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one
• CAS NO: 187242-85-9
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.2096
• Mol File: 187242-85-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one(187242-85-9)
• EPA Substance Registry System: (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one(187242-85-9)

Safety Data

• Hazardous Substances Data: 187242-85-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one is used as a key intermediate in the synthesis of pharmaceuticals for its ability to facilitate the formation of new chemical bonds, contributing to the development of various drugs and chemical compounds.
Used in Organic Chemistry Research and Development:
In the field of organic chemistry, (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one serves as a building block for the creation of new materials and substances, supporting research and development efforts aimed at discovering innovative applications and products.
Used in Chemical Compound Production:
(E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one is utilized as a fundamental component in the production of a range of chemical compounds, leveraging its reactivity to enhance the synthesis process and yield of desired products.

Upstream product

• 6342-56-9 Pyruvic aldehyde dimethyl acetal 
• 68-12-2 N,N-dimethyl-formamide 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 

Downstream Products

• 111573-59-2 pyrazole-3-carboxaldehyde dimethylacetal 
• 180869-36-7 4-dimethoxymethyl-2-methylsulfanylpyrimidine 
• 165807-05-6 4-(dimethoxymethyl)pyrimidin-2-amine 
• 180869-38-9 4-(dimethoxymethyl)-N-methylpyrimidin-2-amine 
• 165807-06-7 2-Aminopyrimidine-4-carboxaldehyde 
• 180869-44-7 2-acetamidopyrimidine-4-carboxaldehyde 
• 914348-07-5 2-cyclopropyl-4-(dimethoxymethyl)pyrimidine 
• 914347-52-7 5-bromo-4-(dimethoxymethyl)pyrimidin-2-amine 
• 156825-33-1 4-(dimethoxymethyl)-2-(2-pyridyl)pyrimidine 
• 874279-26-2 4-(dimethoxymethyl)-2-(methylsulfonyl)pyrimidine 
• 878760-47-5 4-(dimethoxymethyl)-2-(trifluoromethyl)pyrimidine 
• 193747-11-4 2-propylthiopyrimidine-4-carboxaldehyde dimethyl acetal 
• 27258-32-8 1-methyl-1H-pyrazole-3-carbaldehyde 
• 27258-33-9 1-methyl-1H-pyrazole-5-carbaldehyde 

Relevant articles and documents

Synthesis of trans-disubstituted pyrazolylcyclopropane building blocks

Diastereoselective synthesis of trans-disubstituted pyrazolylcyclopropane building blocks (i.e. carboxylic acids and amines) is described starting from easily available pyrazolecarbaldehydes. The key step of the synthesis was Corey–Chaikowsky cyclopropanation of the corresponding α,β-unsaturated Weinreb amides. The title compounds were prepared in four or six steps and 32–60 and 17–40?% overall yields, respectively, on up to 50?g scale. The building blocks obtained are good starting points for the design of lead-like libraries; they themselves can be considered as isosteric analogs of CNS-active drug tranylcyclopropamine. Graphical abstract: [Figure not available: see fulltext.]

A PESTICIDALLY ACTIVE MIXTURE COMPRISING PYRAZOLOPYRIDINE ANTHRANILAMIDE COMPOUND, OXIDES OR SALTS THEREOF

The present invention relates to a pesticidal active mixture comprising pyrazolopyridine anthranilamide compound of formula (I), oxides or a salt thereof, Formula (I) wherein, R1, R2, R3, R4, Z and E are as defined in the description, and at least one insecticidally active compound (II) or at least one fungicidally active compound (III).

Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor

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A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

The mechanistic target of rapamycin (mTOR) plays a pivotal role in growth and tumor progression and is an attractive target for cancer treatment. ATP-competitive mTOR kinase inhibitors (TORKi) have the potential to overcome limitations of rapamycin derivatives in a wide range of malignancies. Herein, we exploit a conformational restriction approach to explore a novel chemical space for the generation of TORKi. Structure-activity relationship (SAR) studies led to the identification of compound 12b with a ～450-fold selectivity for mTOR over class I PI3K isoforms. Pharmacokinetic studies in male Sprague Dawley rats highlighted a good exposure after oral dosing and a minimum brain penetration. CYP450 reactive phenotyping pointed out the high metabolic stability of 12b. These results identify the tricyclic pyrimido-pyrrolo-oxazine moiety as a novel scaffold for the development of highly selective mTOR inhibitors for cancer treatment.

Macrocyclic MCL-1 inhibitors and methods of use

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME.

The present invention provides novel pyrazolopyridine-diamides of Formula (I), wherein, the definition of W1, W2, A1, A2, A3, B1, B2, D, Z1, E, R1, R2, R3, R4, m and n is as described in the description. The present invention also relates to the composition, combination, use and method of application of the compounds of Formula (I).

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

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NEW AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

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