2051-18-5Relevant articles and documents
Synthesis of chlorinated alkylbibenzyls and 9-chlororetene
Nevalainen, T.
, p. 847 - 854 (1995)
The synthesis of chlorinated alkylbibenzyls and 9-chlororetene is described. These compounds were synthesized for use as model compounds in analytical and toxicological characterization. The structures of the synthesized model compounds found to be very similar to those indentified in pulp mill effluent and products. The (1)H NMR and mass spectral data for the compounds are also reported.
Preparation method of P-isopropyl benzaldehyde and from isopropylbenzene
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Paragraph 0058-0061; 0066-0068; 0072-0074; 0079-0081; ..., (2021/10/30)
The invention provides a method for preparing p-isopropylbenzaldehyde and from isopropylbenzaldehyde, and the preparation method comprises the following steps of: one step. The method comprises the following steps: adding cumene, an aldehyde solution, dropwise adding hydrochloric acid, heating to 80 - 88 °C after charging, and separating the phase to obtain the organic phase. The method comprises the following steps: uniformly mixing the inorganic base, the water and the phase transfer catalyst into a hydrolysis solution, adding the organic phase obtained in the step, and carrying out phase separation and purification under stirring to obtain p-isopropylbenzyl alcohol. Step III. The method comprises the following steps: adding hydrogen peroxide to isopropyl benzyl alcohol, a catalyst and a phase transfer catalyst obtained in the steps of oxidation and adding hydrogen peroxide, filtering and separating the filtrate to obtain crude aldehyde crude product and purifying to obtain p-propyl benzaldehyde. The preparation method has the advantages of being low in cost, good in process selectivity, mild in process condition and easy to realize industrialization.
Triazole derivative as well as preparation method and application thereof
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Paragraph 0053-0055; 0065-0066; 0068, (2020/06/09)
The invention relates to a triazole derivative as well as a preparation method and application thereof, which belong to the technical field of organic synthetic drugs. The structure of the triazole derivative is shown as a formula I. In the formula I, R1 and R2 are H, Cl, Br,-CF3,-CH(CH3)2 or -OCH3, and R1 and R2 are not H at the same time. R3 is -CH2 or -COCH2; X and Y are N or C, X and Y are not C at the same time, and X and Y are not N at the same time. The triazole derivative disclosed by the invention has a certain inhibition effect on germs of various crop diseases. Small toxic andside effects on plants are achieved. The preparation method of the triazole derivative is simple.
An efficient and convenient chloromethylation of some aromatic compounds catalyzed by zinc iodide
Tang, Jian,Liu, Hongtao,Zhou, Jing,Zhang, Xingxian
, p. 34 - 38 (2019/06/21)
Treatment of a series of aromatic hydrocarbons and O-carbethoxy phenol substrates with a mixture of chlorosulfonic acid and dimethoxymethane in CH2Cl2 catalyzed by zinc iodide affords the corresponding chloromethyl derivatives in good to excellent yields.
A practical and convenient Blanc-type chloromethylation catalyzed by zinc chloride under solvent-free conditions
Tang, Jian,Liu, Hongtao,He, Kailun,Zhang, Xingxian
, p. 925 - 932 (2019/03/17)
Chloromethylation of various aromatic hydrocarbons and substituted phenolic derivatives with dimethoxymethane and chlorosulfonic acid was carried out in the presence of 10 mol% of ZnCl2 in a mild and efficient manner under solvent-free conditions. In addition, 2,6-dimethyltyrosine was synthesized in high yield via this protocol.
NMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides
Zheng, Dagui,Mao, Liu-Liang,Zhu, Xian-Hong,Zhou, An-Xi
supporting information, p. 2793 - 2800 (2018/11/06)
NMP-mediated chlorination of aliphatic alcohols has been developed for the synthesis of alkyl chlorides. This facile, efficient and practical approach used simple and readily available aryl sulfonyl chlorides as the chlorination reagent for the construction of C–Cl bond in good to excellent yields with mild conditions and broad substrate scope.
Syntheses of 7-Substituted Anthra[2,3- b]thiophene Derivatives and Naphtho[2,3- b:6,7- b']dithiophene
Al-Jumaili, Mustafa A.,Woodward, Simon
, p. 11437 - 11445 (2018/09/06)
7-R-Anthra[2,3-b]thiophene derivatives (1, R = H, Me, i-Pr, or MeO) are prepared in three steps (in average overall yield >50%) starting from (E)-4-RC6H4CH2(HOCH2)C=CI(CH2OH). The latter are commercial or readily prepared from 2-butyne-1,4-diol and ArCH2Cl (both costing 1 cent/mmol) at 10 g scales. These allow for the selective formation of (otherwise unattainable) higher solubility 7-derivatives. Similar methods allow for the preparation of naphtho[2,3-b:6,7-b']dithiophene 2 using equally low-cost starting materials.
Copper-catalyzed cyanation of benzyl chlorides with non-toxic K 4[Fe(CN)6]
Ren, Yunlai,Dong, Chuanhua,Zhao, Shuang,Sun, Yanpei,Wang, Jianji,Ma, Junying,Hou, Chaodong
supporting information; body text, p. 2825 - 2827 (2012/07/17)
Copper-based catalysts were firstly introduced into the cyanation of benzyl chlorides with non-toxic K4[Fe(CN)6]. The presented method avoids the use of extremely poisonous alkali cyanides and precious palladium catalysts. No other reagent apart from CuI, K4[Fe(CN) 6] and toluene was used in the cyanation, showing that the presented protocol is simple and practical. A series of benzyl chlorides were smoothly cyanated in up to 85% yield under the optimal conditions.
Pd-catalyzed cyanation of benzyl chlorides with nontoxic K 4[Fe(CN)6]
Ren, Yunlai,Yan, Mengjie,Zhao, Shuang,Sun, Yanpei,Wang, Jianji,Yin, Weiping,Liu, Zhifei
supporting information; body text, p. 5107 - 5109 (2011/10/05)
Non-toxic K4[Fe(CN)6] was demonstrated to be effective as a green cyanating agent for the cyanation of alkyl halides using PPh3/Pd(OAc)2 as a catalyst system. The presented method allowed a series of benzyl chlorides to be smoothly cyanated in up to 88% yield. In order to avoid or suppress the deactivation of the catalyst, the reaction was required to be performed in a stringent inert ambiance.
An inexpensive and convenient procedure for chloromethylation of aromatic hydrocarbons by phase transfer catalysis in aqueous media
Hu, Yu Lin,Lu, Ming,Ge, Qiang,Wang, Peng Cheng,Zhang, Sheng Bin,Lu, Ting Ting
experimental part, p. 97 - 102 (2010/08/05)
Reaction of aromatic hydrocarbons catalyzed by a novel catalytic system consisting of zinc chloride, acetic acid, sulfuric acid and PEG-800 in aqueous media under PTC conditions results in chloromethylation in good to excellent yield.
