2402-83-7Relevant articles and documents
Synthesis and copolymerization of azidomethyl-substituted oxetanes: the morphology of statistical block copolymers
Mukhametshin, Timur I.,Petrov, Aleksei I.,Kuznetsova, Nina V.,Petrov, Vladimir A.,Averianova, Natalia V.,Garaev, Ilgiz Kh.,Kostochko, Anatoly V.,Gubaidullin, Aidar T.,Vinogradov, Dmitry B.,Bulatov, Pavel V.
, p. 811 - 821 (2017/09/06)
[Figure not available: see fulltext.] 3,3-Bis(azidomethyl)oxetane and 3-azidomethyl-3-methyloxetane were obtained by bromination of pentaerythritol and metriol with a mixture of hydrobromic, acetic, and sulfuric acids, followed by cyclization in the presence of a phase-transfer catalyst TBAB, with the formation of oxetane ring and replacement of bromide substituents with azide ions. The copolymerization reaction of 3,3-bis-(azidomethyl)oxetane and 3-azidomethyl-3-methyloxetane was performed in the presence of a catalytic system prepared from triisobutylaluminum and water. The methods of small-angle and wide-angle X-ray diffraction analysis were used to determine the amorphous-crystalline and domain structures of the synthesized copolymers. We also present data about conformational and relaxation transitions in these statistical copolymers.
Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts
Van Der Haas, Richard N. S.,Dekker, Jeroen A.,Hassfeld, Jorma,Hager, Anastasia,Fey, Peter,Rubenbauer, Philipp,Damen, Eric
, p. 2394 - 2401 (2017/05/22)
An improved synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. While this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.
The Development of a Manufacturing Route to an MCHr1 Antagonist
Golden, Michael,Legg, Danny,Milne, David,Arun Bharadwaj,Deepthi,Gopal, Madan,Dokka, Nagaraju,Nambiar, Sudhir,Ramachandra, Puranik,Santhosh,Sharma, Parhalad,Sridharan,Sulur, Manjunatha,Linderberg, Mats,Nilsson, Anders,Sohlberg, Roger,Kremers, John,Oliver, Samuel,Patra, Debasis
, p. 675 - 682 (2016/04/01)
Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.
Synthesis and structural characterization of ruthenium(II) complexes bearing phosphine-pyrazolyl based tripod ligands
Tan, Weiqiang,Zhao, Xiaodan,Yu, Zhengkun
, p. 5395 - 5402 (2008/03/12)
Phosphine-pyrazolyl based tripod ligands ROCH2C(CH2Pz)2(CH2PPh2) (R = H, Me, allyl; Pz = pyrazol-1-yl) were efficiently synthesized and characterized. Reactions of these ligands with [Ru(η6-p-cymene)Cl2]2 afforded complexes of the type [Ru(η6-p-cymene)Cl2](L) (6-8) in which the ligands exhibit κ1-P-coordination to the metal center. Complex [Ru(η6-p-cymene)Cl2{Ph2PCH2C(CH2OH)(CH2Pz)2}] (6) underwent chloride-dissociation in CH2Cl2/MeCN to give complex [RuCl(η6-p-cymene){κ2(P,N)-Ph2PCH2C(CH2OH)(CH2Pz)2}][Cl] (9). Complexes 6-9 demonstrated poor to moderate catalytic activity in the transfer hydrogenation of acetophenone. All these complexes were fully characterized by analytical and spectroscopic methods and their molecular structures were determined by X-ray crystallographic study.
Chemical transformation of 3-bromo-2,2-bis(bromomethyl)-propanol under basic conditions
Ezra, Shai,Feinstein, Shimon,Bilkis, Itzhak,Adar, Eilon,Ganor, Jiwchar
, p. 505 - 512 (2007/10/03)
The mechanism of the spontaneous decomposition of 3-bromo-2,2- bis(bromomethyl)propanol (TBNPA) and the kinetics of the reaction of the parent compound and two subsequent products were determined in aqueous solution at temperatures from 30 to 70 °C and pH from 7.0 to 9.5. TBNPA is decomposed by a sequence of reactions that form 3,3-bis(bromomethyl)oxetane (BBMO), 3-bromomethyl-3-hydroxymethyloxetane (BMHMO), and 2,6-dioxaspiro[3.3]-heptane (DOH), releasing one bromide ion at each stage. The pseudo-first-order rate constant of the decomposition of TBNPA increases linearly with the pH. The apparent activation energy of this transformation (98 ± 2 KJ/mol) was calculated from the change of the effective second-order rate constant with temperature. The pseudoactivation energies of BBMO and BMHMO were estimated to be 109 and 151 KJ/mol, respectively. Good agreement was found between the rate coefficients derived from changes in the organic molecules concentrations and those determined from the changes in the Br- concentrations. TBNPA is the most abundant semivolatile organic pollutant in the aquitard studied, and together with its byproducts they posess an environmental hazard. TBNPA half-life is estimated to be about 100 years. This implies that high concentrations of TBNPA will persist in the aquifer long after the elimination of all its sources.
(Gem-heterocyclodimethanamine-N,N')platinum complexes
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, (2008/06/13)
Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.
Arylsulphonyl azetidine compounds, their preparation and their use as intermediates
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, (2008/06/13)
Azetidine compounds of the general formula I STR1 wherein Ar represents a para-tolyl group and X represents a hydrogen atom, a carboxyl group or a hydroxymethyl group; their preparation from pentaerythritol via compounds of formula STR2 or two hydroxyl groups and Z represents Hal or OH, together with their use as intermediates in the preparation of 3-carboxyazetidine; also the compounds of formula STR3 wherein R1 and R2 both represent hydrogen, or together represent STR4 The compounds are intermediates for a known chemical hybridizing agent.
Trifluoromethanesulfonates
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, (2008/06/13)
Novel esters of the formula: STR1 promote char formation in polymer compositions containing a monovinylidene aromatic monomer, such as styrene, and an ethylenically unsaturated carboxylic anhydride, such as maleic anhydride. In such esters, R is an n-valent tertiary hydrocarbyl radical, an n-valent tertiary chlorohydrocarbyl radical, an n-valent tertiary hydrocarbyl radical containing at least one chain linkage of oxygen or an inertly substituted n-valent tertiary hydrocarbyl radical containing at least one bromine atom.
