25109-28-8

Basic information

• Product Name: 1-Bromo-4-cyclohexylbenzene
• Synonyms: 1-BROMO-4-CYCLOHEXYLBENZENE;4-BROMOPHENYLCYCLOHEXANE;4-Cyclohexylbromobenzene;p-bromophenylcyclohexane;4-Bromo-1-cyclohexylbenzene;Ai3-11173;Benzene, 1-bromo-4-cyclohexyl-;Einecs 246-623-3
• CAS NO: 25109-28-8
• Molecular Formula: C₁₂H₁₅Br
• Molecular Weight: 239.15
• EINECS: 246-623-3
• Mol File: 25109-28-8.mol

Chemical Properties

• Boiling Point: 90-94°C 0,01mm
• Flash Point: 90-94°C/0.01mm
• Appearance: /
• Density: 1,287 g/cm3
• Vapor Pressure: 0.00366mmHg at 25°C
• Refractive Index: 1.5595
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Not miscible or difficult to mix with water.
• BRN: 2209869
• CAS DataBase Reference: 1-Bromo-4-cyclohexylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-cyclohexylbenzene(25109-28-8)
• EPA Substance Registry System: 1-Bromo-4-cyclohexylbenzene(25109-28-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 25109-28-8(Hazardous Substances Data)

Usage

Uses

Used in Electronics Industry:
1-Bromo-4-cyclohexylbenzene is used as a material in the manufacturing of organic light-emitting diodes (OLEDs). Its chemical properties contribute to the efficient functioning of these devices, which are widely used in display technologies and lighting applications due to their high energy efficiency, thin and lightweight design, and fast response times.
Used in Pharmaceutical Industry:
1-Bromo-4-cyclohexylbenzene serves as a valuable intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for further chemical modifications, making it a versatile building block in the development of new drugs. The compound's role in the pharmaceutical industry highlights its importance in the creation of novel therapeutic agents that can address a range of health concerns.

InChI:InChI=1/C12H15Br/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h6-10H,1-5H2

Upstream product

• 108-86-1 bromobenzene 
• 542-18-7 cyclohexyl chloride 
• 827-52-1 1-phenyl-1-cyclohexane 
• 6373-50-8 p-cyclohexylaniline 
• 110-83-8 cyclohexene 
• 108-93-0 cyclohexanol 
• 25158-78-5 3-(4-bromophenyl)cyclohexan-1-one 
• 16156-56-2 cyclohexyl mesylate 
• 7664-93-9 sulfuric acid 
• 7446-70-0 aluminium trichloride 
• 7726-95-6 bromine 
• 7553-56-2 iodine 
• 5458-48-0 4-cyclohexylnitrobenzene 
• 930-68-7 cyclohexenone 

Downstream Products

• 81937-29-3 4,4'-Dicyclohexyl-biphenyl 
• 57803-90-4 3-(4-Cyclohexyl-phenyl)-1H-indene 
• 6728-90-1 3-(p-Cyclohexyl-phenyl)-2-hydroxy-propylchlorid 
• 586-76-5 4-Bromobenzoic acid 
• 87-82-1 hexabromobenzene 
• 13020-34-3 4-cyclohexyl styrene 
• 873381-46-5 (4-cyclohexylphenyl)diphenylmethanol 
• 861097-00-9 Hydroxy-phenyl-bis-(4-cyclohexyl-phenyl)-methan 
• 872793-68-5 Hydroxy-tris-(4-cyclohexyl-phenyl)-methan 
• 20029-52-1 4-cyclohexylbenzoic acid 
• 6732-52-1 4-(4-Cyclohexyl-phenyl)-3-hydroxy-buttersaeurenitril 
• 6732-30-5 4-(p-Cyclohexyl-phenyl)-3-hydroxy-buttersaeureethylester 
• 820223-94-7 4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl))phenylcyclohexane 
• 57263-22-6 1-(4-cyclohexyl-phenyl)-2,2,4,4-tetramethyl-3-(4-pyridin-2-yl-piperazin-1-yl)-cyclobutanol 

Relevant articles and documents

Organic compound and, electronic component using same, and electronic device

The invention belongs to the field of organic materials, and relates to an organic compound and and an electronic device using the same, wherein the organic compound has the structure shown in Chemical Formula 1, the organic compound is applied to an organic electroluminescent device, and the performance of the device can be remarkably improved.

Organic compound, electronic device and electronic device (by machine translation)

The present application relates to an organic compound, and containing an electronic device containing the organic compound and an electronic device, containing the organic compound, wherein the organic compound, main body is shown as a large planar structure, in a steric space by introducing an electron rich arylamine or a heteroarylamine substituent, at 9 position of the fluorene or the silicon fluorenyl group such that the hole transport performance of the compound is excellent. (by machine translation)

Ni-catalyzed Reductive Deaminative Arylation at sp3 Carbon Centers

A Ni-catalyzed reductive deaminative arylation at unactivated sp3 carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp3 C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

C?I-Selective Cross-Coupling Enabled by a Cationic Palladium Trimer

While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air-stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C?I over C?Br bonds in C?C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd0 and PdI-PdI catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible.

Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids

A transformation analogous in simplicity and functional group tolerance to the venerable Suzuki cross-coupling between alkyl-carboxylic acids and boronic acids is described. This Ni-catalyzed reaction relies upon the activation of alkyl carboxylic acids as their redox-active ester derivatives, specifically N-hydroxy-tetrachlorophthalimide (TCNHPI), and proceeds in a practical and scalable fashion. The inexpensive nature of the reaction components (NiCl2?6 H2O—$9.5 mol?1, Et3N) coupled to the virtually unlimited commercial catalog of available starting materials bodes well for its rapid adoption.

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes

(Chemical Equation Presented) Conversion of ester moieties into 4-bromophenyl groups was effected by means of a four-step protocol: a Grignard reaction of the ester with allylmagnesium halides, a ring-closing metathesis, dibromocyclopropanation, and an electrocyclic reaction of the dibromocyclopropanes.

Iron-catalyzed arene alkylation reactions with unactivated secondary alcohols

A simple, iron-based catalytic system allows for the inter- and intramolecular arylation of unactivated secondary alcohols. This transformation expands the substrate scope beyond the previously required activated alcohols and proceeds under mild reaction conditions, tolerating air and moisture. Furthermore, the use of an enantioenriched secondary alcohol provides an enantioenriched product for the intramolecular reaction, thereby offering a convenient approach to nonracemic products.

Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes

A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.

A new convenient Friedel-Crafts alkylation of aromatic compounds with secondary alcohol methanesulfonates in the presence of scandium(III) trifluoromethanesulfonate or trifluoromethanesulfonic acid as the catalyst

Scandium(III) triflate and triflic acid were both found to be efficient catalysts for the Friedel-Crafts alkylation of aromatic compounds using methanesulfonates derived from secondary alcohols as alkylating agents.