Xi:Irritant;33401-74-0Relevant articles and documents
Asymmetric reduction of 3-aryl-3-keto esters using Rhizopus species
Salvi, Neeta A.,Chattopadhyay, Subrata
, p. 4918 - 4922 (2006)
Ethyl 3-aryl-3-oxopropanoates (aryl: phenyl, 2-fluorophenyl, 3-nitrophenyl, and 4-nitrophenyl) were reduced enantioselectively to the corresponding (S)-alcohols by the fungus Rhizopus arrhizus and other Rhizopus sp. The best results were generally obtaine
Asymmetric synthesis XXV: Enantioselective synthesis of ethyl β-hydroxy-β-phenyl propanoate via an asymmetric Reformatsky reaction
Mi,Wang,Chen,Jiang,Chan,Yang
, p. 2641 - 2642 (1995)
Both stoichiometric and catalytic amounts of N,N-dialkyl derivatives of D or L-1,2-diphenyl aminoalcohols were used as chiral ligands in the enantioselective Reformatsky reaction of benzaldehyde with ethyl bromoacetate at reflux in the presence of Zn-Cu c
Asymmetric synthesis XXVI: Catalytic enantioselective syntheses of β-hydroxy esters via double chiral induction in asymmetric Reformatsky reactions
Mi, Aiqiao,Wang, Zhaoyang,Zhang, Junmei,Jiang, Yaozhong
, p. 1469 - 1473 (1997)
Catalytic asymmetric Reformatsky reactions of benzaldehyde with optically active menthyl bromoacetates in the presence of Zn-Cu couple were performed using 0.25 equiv. of (1R,2S) or (1S,2R)-N,N-dimethyl-2-amino-1,2-diphenyl ethanol as chiral ligand to obt
Trifluoromethylated amino alcohols as chiral ligands for highly enantioselective Reformatsky reaction
Fujiwara, Yasuyuki,Katagiri, Toshimasa,Uneyama, Kenji
, p. 6161 - 6163 (2003)
The enantioselective Reformatsky reaction of PhCHO was achieved by the use of trifluoromethylated amino alcohols as chiral ligands to afford the corresponding optically active β-hydroxy ester with up to 90% ee.
Enantioselective synthesis of a key intermediate aldehyde toward the polyene macrolide filipin III, based on a chiral oxazaborolidinone-promoted asymmetric aldol reaction
Kiyooka, Syun-Ichi,Hena, Mostofa A.,Goto, Fumitaka
, p. 2871 - 2879 (1999)
A versatile preparation of an enantiopure aldehyde useful for the asymmetric total synthesis of filipin III was developed using a chiral oxazaborolidinone-promoted asymmetric aldol reaction with a dithiolane silyl nucleophile. The sign and magnitude of th
Ruthenium catalyzed asymmetric transfer hydrogenation of β-ketoesters
Everaere, Kathelyne,Carpentier, Jean-Francois,Mortreux, Andre,Bulliard, Michel
, p. 2971 - 2974 (1998)
Chemoselective transfer hydrogenation of β-ketoesters to the corresponding alcohols is achieved in the presence of catalytic combinations of [RuCl2(η6-arene)]2 and ephedrine or diamino type chiral ligands with activities u
Immobilized microorganisms in the reduction of ethyl benzoylacetate
Ramos, Aline de Souza,Ribeiro, Joyce Benzaquem,Vazquez, Leonardo,Fiaux, Sorele Batista,Leite, Selma Gomes Ferreira,Ramos, Maria da Concei??o Klaus V.,Neto, Francisco Radler de Aquino,Antunes
, p. 7362 - 7364 (2009)
The enantioselective reduction of ethyl benzoylacetate (EBA) into ethyl (S)-3-hydroxy-3-phenylpropanoate (S-HPPE) by nine yeast strains and three filamentous fungi strains is described. The conversion obtained was in the range 0-89% and the enantiomeric excess was 100% in many cases. Conversion levels were higher when the reduction was performed with microorganisms immobilized in calcium alginate and enantioselectivity remained excellent. Some reaction's conditions of bioreduction by immobilized cells of Rhodotorula rubra were studied using a 25-2 fractional factorial design.
Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof
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Paragraph 0103-0104; 0110-0114, (2021/06/26)
The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.
Structure-guided evolution of a ketoreductase for efficient and stereoselective bioreduction of bulky α-amino β-keto esters
Chen, Liuqing,Chen, Shaoxin,Feng, Meiqing,Ni, Guowei,Tang, Jiawei,Wang, Hongyi,Yu, Jun,Yuan, Shuguang,Zhang, Fuli,Zhang, Luwen
, p. 6755 - 6769 (2021/10/25)
Ketoreductases have shown considerable potential as biocatalysts in the asymmetric synthesis of chiral alcohols. However, compared to the widely studied ketoreductases for chiral alcohols, limited knowledge is available about ketoreductases for efficient
Enantioselective Reformatsky Reaction of Ketones Catalyzed by Chiral Indolinylmethanol
Luo, Renshi,Chen, Miao-Miao,Ouyang, Lu,Chan, Albert S. C.,Lu, Gui
supporting information, p. 4805 - 4811 (2020/07/14)
A reliable and practical Reformatsky reaction of ethyl iodide acetate with ketones for the synthesis of chiral β-hydroxyl carbonyl compounds in good yields and excellent enantioselectivities is presented. A readily available dihydroindole derivative was u
