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1,1,2,2-Tetrafluoroethyl methyl ether, also known as CF3CH2OCH3, is a colorless, flammable liquid with a mild ether-like odor. It is a fluorinated ether compound known for its low toxicity and low environmental impact, making it an attractive choice for industries seeking sustainable and environmentally friendly solvents. However, due to its high flammability and potential to form explosive peroxides when exposed to air, it requires careful handling.

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  • 425-88-7 Structure
  • Basic information

    1. Product Name: 1,1,2,2-Tetrafluoroethyl methyl ether
    2. Synonyms: 1,1,2,2-TETRAFLUOROETHYL METHYL ETHER;1,1,2,2-TETRAFLUORO-1-METHOXYETHANE;METHYL 1,1,2,2-TETRAFLUOROETHYL ETHER;Methyl 1,1,2,2-tetrafluoroethyl ether 98%;Methyl1,1,2,2-tetrafluoroethylether98%;1,1,2,2-Tetrafluoro-3-oxabutane;Methyl 1,1,2,2-tetrafluoroethyl ether, 1-Methoxy-1,1,2,2-tetrafluoroethane;Methyl 2H-tetrafluoroethyl ether 98%
    3. CAS NO:425-88-7
    4. Molecular Formula: C3H4F4O
    5. Molecular Weight: 132.06
    6. EINECS: 207-039-4
    7. Product Categories: refrigerants
    8. Mol File: 425-88-7.mol
  • Chemical Properties

    1. Melting Point: -107°C
    2. Boiling Point: 36-37°C
    3. Flash Point: -20 °C
    4. Appearance: /
    5. Density: 1,294 g/cm3
    6. Vapor Pressure: 1280mmHg at 25°C
    7. Refractive Index: 1.284
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. BRN: 1737755
    11. CAS DataBase Reference: 1,1,2,2-Tetrafluoroethyl methyl ether(CAS DataBase Reference)
    12. NIST Chemistry Reference: 1,1,2,2-Tetrafluoroethyl methyl ether(425-88-7)
    13. EPA Substance Registry System: 1,1,2,2-Tetrafluoroethyl methyl ether(425-88-7)
  • Safety Data

    1. Hazard Codes: T,Xi,F+
    2. Statements: 23/24/25-36/37/38-12-11
    3. Safety Statements: 36/37/39-45-36-33-26-16-9
    4. RIDADR: 3271
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 3
    8. PackingGroup: II
    9. Hazardous Substances Data: 425-88-7(Hazardous Substances Data)

425-88-7 Usage

Uses

Used in Pharmaceutical Industry:
1,1,2,2-Tetrafluoroethyl methyl ether is used as a solvent in the production of pharmaceuticals for its ability to dissolve a wide range of compounds and facilitate various chemical reactions. Its low toxicity and environmental impact make it a preferred choice for the development of safer and more eco-friendly medications.
Used in Agrochemical Industry:
In the agrochemical sector, 1,1,2,2-Tetrafluoroethyl methyl ether serves as a solvent for the synthesis of various agrochemicals, such as pesticides and herbicides. Its properties allow for efficient production processes and contribute to the development of effective and environmentally conscious agricultural products.
Used in Polymer Industry:
1,1,2,2-Tetrafluoroethyl methyl ether is utilized as a solvent in the production of polymers, aiding in the synthesis and processing of a variety of polymeric materials. Its low toxicity and environmental impact are advantageous for creating polymers that are safer for use in various applications, including consumer products and industrial materials.
Used as a Refrigerant:
1,1,2,2-Tetrafluoroethyl methyl ether is employed as a refrigerant in cooling systems due to its thermodynamic properties, which allow for efficient heat transfer and cooling. Its low environmental impact makes it a more sustainable option compared to traditional refrigerants.
Used as a Propellant in Aerosol Products:
In the aerosol industry, 1,1,2,2-Tetrafluoroethyl methyl ether is used as a propellant to dispense products such as personal care items, cleaning solutions, and other sprays. Its low toxicity and environmental impact contribute to the development of safer and more eco-friendly aerosol products.

Check Digit Verification of cas no

The CAS Registry Mumber 425-88-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 425-88:
(5*4)+(4*2)+(3*5)+(2*8)+(1*8)=67
67 % 10 = 7
So 425-88-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H4F4O/c1-8-3(6,7)2(4)5/h2H,1H3

425-88-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M2514)  Methyl 1,1,2,2-Tetrafluoroethyl Ether  >98.0%(GC)

  • 425-88-7

  • 25g

  • 890.00CNY

  • Detail
  • Alfa Aesar

  • (L17889)  1,1,2,2-Tetrafluoroethyl methyl ether, 99%   

  • 425-88-7

  • 5g

  • 388.0CNY

  • Detail
  • Alfa Aesar

  • (L17889)  1,1,2,2-Tetrafluoroethyl methyl ether, 99%   

  • 425-88-7

  • 25g

  • 1421.0CNY

  • Detail

425-88-7Synthetic route

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

sodium methylate
124-41-4

sodium methylate

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

Conditions
ConditionsYield
under 14710.2 Torr;
In 1,4-dioxane
methyl hypofluorite
36336-08-0

methyl hypofluorite

1,1,2-trifluoroethylene
359-11-5

1,1,2-trifluoroethylene

A

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

B

(1,2,2,2-tetrafluoroethyl)methyl ether
50285-05-7

(1,2,2,2-tetrafluoroethyl)methyl ether

Conditions
ConditionsYield
In [D3]acetonitrile at -78 - 20℃; Title compound not separated from byproducts;
methanol
67-56-1

methanol

polytetrafluoroethylene
116-14-3

polytetrafluoroethylene

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

Conditions
ConditionsYield
With sodium methylate
benzophenone
119-61-9

benzophenone

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1-diphenyl-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

1,1-diphenyl-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;99%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

difluoroacetic acid methyl ester
433-53-4

difluoroacetic acid methyl ester

Conditions
ConditionsYield
With water; fluorinated γ-alumina at 180℃; for 0.02h; Product distribution / selectivity; Inert atmosphere; Gas phase;94.5%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
With alumina; hydrogen fluoride at 220 - 230℃;90%
With aluminum oxide at 200 - 300℃;90%
With antimony pentafluoride In 1,2-dichloro-ethane at 25℃; for 3h; Autoclave;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

Methyl fluoride
593-53-3

Methyl fluoride

B

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
antimony pentafluoride In neat (no solvent)A n/a
B 88%
aluminum phosphate treatment with HF at 300C for 72 h at 210℃; Product distribution / selectivity; Inert atmosphere;
With monoaluminum phosphate; hydrogen fluoride at 200℃; Inert atmosphere; Autoclave;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

4,4'-Difluorobenzophenone
345-92-6

4,4'-Difluorobenzophenone

1,1-bis(4-fluorophenyl)-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

1,1-bis(4-fluorophenyl)-2,2,3,3-tetrafluoro-3-methoxypropan-1-ol

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;75%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

N-benzylidene-4-(trifluoromethyl)aniline
351-98-4

N-benzylidene-4-(trifluoromethyl)aniline

N-(4-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

N-(4-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

Conditions
ConditionsYield
With potassium hexamethylsilazane In N,N-dimethyl-formamide at -10℃; for 0.5h;61%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

potassium 2,2-difluoroacetate

potassium 2,2-difluoroacetate

Conditions
ConditionsYield
With methanol; potassium hydroxide at 50℃; for 8 - 16h; Product distribution / selectivity;51.7%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

N-[phenylmethylidene]-3-(trifluoromethyl)aniline

N-[phenylmethylidene]-3-(trifluoromethyl)aniline

N-(3-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

N-(3-trifluoromethylphenyl)-1-phenyl-2,2,3,3-tetrafluoro-3-methoxypropylamine

Conditions
ConditionsYield
With potassium hexamethylsilazane In N,N-dimethyl-formamide at -10℃; for 0.5h;49%
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether
428-93-3

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether

Conditions
ConditionsYield
With chlorine Irradiation;
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2-Tetrafluorethyldichlormethylether
32776-68-4

1,1,2,2-Tetrafluorethyldichlormethylether

Conditions
ConditionsYield
With chlorine Irradiation;
With chlorine
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2-Tetrafluorethyltrichlormethylether
32776-69-5

1,1,2,2-Tetrafluorethyltrichlormethylether

Conditions
ConditionsYield
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

(2-Chlor-1,1,2,2-tetrafluor-ethyl)-trichlormethyl-ether
32776-70-8

(2-Chlor-1,1,2,2-tetrafluor-ethyl)-trichlormethyl-ether

Conditions
ConditionsYield
With chlorine Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

chlorine
7782-50-5

chlorine

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether
428-93-3

chloromethyl-(1,1,2,2-tetrafluoro-ethyl)-ether

Conditions
ConditionsYield
Irradiation;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

C3H3F4O

C3H3F4O

B

C3H3F4O

C3H3F4O

Conditions
ConditionsYield
With clorine at -0.15℃; Kinetics; Further Variations:; Temperatures;
methanol
67-56-1

methanol

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)-propane
40573-09-9

1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)-propane

A

methyl 4-oxaperfluoropentanoate
356-69-4

methyl 4-oxaperfluoropentanoate

B

perfluoro-3,7-dioxaoctanoic acid methyl ester
1093074-17-9

perfluoro-3,7-dioxaoctanoic acid methyl ester

Conditions
ConditionsYield
With oxygen; perfluoro (3,6-dioxa-heptanoic acid) methyl ester; boron trifluoride at 85℃;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

methylene chloride
74-87-3

methylene chloride

B

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

C

2,2-difluoroacetyl fluoride
2925-22-6

2,2-difluoroacetyl fluoride

Conditions
ConditionsYield
With calcium chloride at 200℃; Inert atmosphere; Autoclave;A 71.386 %Chromat.
B 16.22 %Chromat.
C 10.657 %Chromat.
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

A

methylene chloride
74-87-3

methylene chloride

B

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

Conditions
ConditionsYield
With calcium chloride at 200℃; Temperature; Inert atmosphere; Autoclave;A 70.762 %Chromat.
B 27.992 %Chromat.
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

difluoroacetyl chloride
381-72-6

difluoroacetyl chloride

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-1-methoxyethane With hydrogen fluoride at 175℃; Inert atmosphere; Autoclave;
Stage #2: With calcium chloride at 160℃; Inert atmosphere; Autoclave;
93.769 %Chromat.
methanol
67-56-1

methanol

1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

3-dimethylaminoacrylonitrile
2407-68-3

3-dimethylaminoacrylonitrile

methylhydrazine
60-34-4

methylhydrazine

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole carboximidoate hydrochloric acid salt

methyl 3-(difluoromethyl)-1-methyl-1H-pyrazole carboximidoate hydrochloric acid salt

Conditions
ConditionsYield
Stage #1: 1,1,2,2-tetrafluoro-1-methoxyethane; 3-dimethylaminoacrylonitrile With FeCl3/C; triethylamine In toluene at 10 - 15℃; for 2h; Inert atmosphere;
Stage #2: methylhydrazine With sodium hydroxide In water; toluene at 0℃; for 3h;
Stage #3: methanol Further stages;
1,1,2,2-tetrafluoro-1-methoxyethane
425-88-7

1,1,2,2-tetrafluoro-1-methoxyethane

methyl 1,2,2-trifluorovinyl ether
3823-94-7

methyl 1,2,2-trifluorovinyl ether

Conditions
ConditionsYield
With sodium ethanolate

425-88-7Relevant articles and documents

Nucleophilic difluoroalkylation of benzophenones, benzaldehydes and Schiff's bases by tetrafluoroethyl ether and difluoroacetamide

Vaidyanathaswamy,Raman, G. Anantha,Ramkumar,Anand, Rajdeep

, p. 38 - 49 (2015/03/05)

From gem-difluoromethyl group of 1,1,2,2-tetrafluoroethyl ether and 2,2-difluoroalkylamide, proton can be removed by potassium bis(trimethylsilyl)amide in DMF, THF or toluene. The generated nucleophiles are then condensed with benzophenones, benzaldehydes or Schiff's bases to provide new fluorinated alcohols and amines. Some interesting solvent effects are also observed.

Methyl hypofluorite (MeOF) reactions with various fluoroolefins

Suzuta, Tetsuya,Abe, Takashi,Sekiya, Akira

, p. 3 - 8 (2007/10/03)

The reaction of methyl hypofluorite (MeOF) with certain fluoroolefins, such as CF2=CF2, CF2=CFCF3, CF2=CFOCF3, CF2=CFOMe, CF2=CClF, CF2=CHF, CF2=CH2, CHF=CH2, CF2=CFCF=CF2, occurred in CD3CN or in the presence of NaF. Using neat MeOF in the presence of NaF was a novel method and gave good results. We observed that when more than three fluorine atoms are bonded to the C-C double bond, the addition products were obtained in mostly good yields.

Preparation of difluoroacetic acid fluoride and difluoroacetic acid esters

-

, (2008/06/13)

A method for preparing difluoroacetic acid fluoride, which comprises reacting a 1-alkoxy-1,1,2,2-tetrafluoroethane of the formula HCF2 CF2 OR1 wherein R1 is a C1-4 alkyl group in a gas phase in the presence of a metal oxide catalyst.

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