55304-75-1

Basic information

• Product Name: 2,6-Dichloro-3-(trifluoromethyl)pyridine
• Synonyms: 2,6-Dichloro-3-(trifluoromethyl)pyridine,97%;2,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDIN&;2,6-Dichloro-3-[trifluoromethy;2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+%
• CAS NO: 55304-75-1
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 259-585-8
• Product Categories: Fluorine series;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 55304-75-1.mol

Chemical Properties

• Melting Point: 194 °C
• Boiling Point: 194-196 °C(lit.)
• Flash Point: 218 °F
• Appearance: /
• Density: 2.008 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: n20/D 1.4850(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.84±0.10(Predicted)
• BRN: 1570287
• CAS DataBase Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)
• EPA Substance Registry System: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 55304-75-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H2Cl2F3N/c7-4-2-1-3(5(8)12-4)6(9,10)11/h1-2H

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 108-99-6 3-Methylpyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 148493-37-2 2,6-dichloro-3-iodo-pyridine 
• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 7783-56-4 antimony(III) fluoride 
• 87-69-4 tartaric acid 
• 261956-65-4 2-chloro-5-trifluoromethylpyridine 1-oxide 

Downstream Products

• 78743-29-0 3-chloro-4-(5-trifluoromethyl-6-chloro-pyridin-2-yloxy)aniline 
• 132844-53-2 N-Cyclopropyl-4-methyl-N-<6-chloro-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide 
• 136353-03-2 2-chloro-6-methoxy-3-(trifluoromethyl)pyridine 
• 136353-04-3 6-chloro-2-methoxy-3-(trifluoromethyl)pyridine 
• 132844-56-5 <amino>methylene>propanedioic acid diethyl ester 
• 100366-75-4 2‐iodo‐5‐(trifluoromethyl)pyridine 
• 132844-49-6 2,6-Bis(phenylthio)-3-(trifluoromethyl)pyridine 
• 132844-47-4 6-Chloro-N-cyclopropyl-5-(trifluoromethyl)-2-pyridineamine 
• 132844-46-3 6-Chloro-N-cyclopropyl-3-(trifluoromethyl)-2-pyridineamine 
• 132844-51-0 N-Cyclopropyl-6-(phenylsulfonyl)-3-(trifluoromethyl)-2-pyridinamine 
• 132844-52-1 N-Cyclopropyl-6-(phenylsulfonyl)-5-(trifluoromethyl)-2-pyridinamine 
• 132844-50-9 2,6-Bis(phenylsulfonyl)-3-(trifluoromethyl)pyridine 
• 132844-43-0 N-Cyclopropyl-4-methyl-N-<6-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)-2-pyridinyl>benzenesulfonamide 
• 132844-58-7 1-Cyclopropyl-1,4-dihydro-4-oxo-7-(phenylthio)-6-(trifluoromethyl)-1,8-naphthyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY

The present invention discloses a method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100?150° C. and a pressure of 0.5?5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art.

METHOD FOR SEPARATING AND PURIFYING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE

A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro β-trifluoromethylpyridine compounds by allowing a β-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a β-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro β-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus,2) fractionating a liquid mixture containing chloro β-trifluoromethylpyridine compounds from the reaction apparatus, and3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.

BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR

The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

Compounds with anti-cancer activity

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

SUBSTITUTED BIARYL QUINOLIN-4-YLAMINE ANALOGUES

Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

Preparation of (trifluoromethyl)pyridines under liquid phase conditions

(Trifluoromethyl)pyridine compounds are prepared by contacting (trichloromethyl)pyridine compounds with hydrogen fluoride in the presence of a catalytic amount of a catalyst selected from the group consisting of FeCl2, FeF2 and mixtures thereof under liquid phase conditions. The (trifluoromethyl)pyridine compounds are useful as intermediates for the preparation of agricultural chemicals.

Process for the manufacture of bromopyridines

A novel process for the preparation of 2,4-dibromo-, 2,6-dibromo- and 2,4,6-tribromopyridines, and the new bromopyridines to be obtained therewith, are disclosed. The novel process comprises treating 2,4-dichloro-, 2,6-dichloro- and 2,4,6-trichloropyridines, in an anhydrous organic medium, with gaseous HBr at temperatures between 80° and 130°C, said process being both simple and economical.