6574-98-7Relevant articles and documents
Investigation of BiVO4 structure variations on the dichlorotoluene ammoxidation performance
Li, Xiongjian,Huang, Chi
, p. 866 - 870 (2020/12/30)
In this study, BiVO4 synthesized by hydrothermal and calcination methods were explored as catalysts in the ammoxidation of dichlorotoluenes to shed light on the structure-reactivity correlations. The BiVO4 samples were characterized by X-ray diffraction (XRD), temperature-programmed reduction (TPR), Brunauer–Emmett–Teller (BET), and UV–Vis spectrophotometry. The results showed that the catalytic activity of BiVO4 greatly relied on the structure variations. The hydrothermal prepared BiVO4 exhibited better catalytic activities as a consequence of its greater structure deformation, with maximum yields of 73.1, 72.2, and 70.8% for 3,4-, 2,4- and 2,6- dichlorobenzonitrles, respectively.
SO 2 F 2 -Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles
Ding, Chengrong,Mei, Guangyao,Wang, Haibo,Zhang, Guofu,Zhao, Yiyong
, p. 1484 - 1488 (2019/07/15)
A rapid, simple and mild process for the dehydration of aldoximes to give the corresponding nitriles, which utilizes SO 2 F 2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quantitative yields with great functional group compatibilities in acetonitrile under ambient conditions. Furthermore, an eco-friendly synthetic protocol to access nitriles from aldehydes with ortho -, meta - and para -nitrile groups was also described in aqueous methanol by using inorganic base Na 2 CO 3, and a one-pot synthetic strategy to generate nitriles from aldehydes was proved to be feasible.
Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution
Holmberg-Douglas, Natalie,Nicewicz, David A.
supporting information, p. 7114 - 7118 (2019/09/07)
Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.
Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles
Al-Huniti, Mohammed H.,Rivera-Chávez, José,Colón, Katsuya L.,Stanley, Jarrod L.,Burdette, Joanna E.,Pearce, Cedric J.,Oberlies, Nicholas H.,Croatt, Mitchell P.
, p. 6046 - 6050 (2018/09/27)
A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.
Hydrothermal Synthesis of Urchin-like W-V-O Nanostructures with Excellent Catalytic Performance
Li, Xiongjian,Sun, Li,Hu, Mingjie,Huang, Ronghua,Huang, Chi
, p. 14758 - 14763 (2018/11/23)
Urchinlike W-V-O microspheres have been successfully synthesized for the first time by a one-pot hydrothermal approach. The as-synthesized W-V-O material was characterized by several techniques such as XRD, SEM, TEM, FTIR, EDS, BET, and Raman spectroscopy. The characterization results have revealed that the W-V-O microspheres consist of numerous one-dimensional nanobelts radially grown from the center. The typical nanobelts display rectangular cross sections with lengths of several micrometers, widths of about 50 nm, and thicknesses of approximately 10-20 nm. Vanadium oxides are dispersed highly either on the external surface or inside the channel surface of the hexagonal WO3 structure. In addition, the as-obtained urchin-like W-V-O material was explored as a catalyst for the ammoxidation of 2,4- and 2,6-dichlorotoluene to the corresponding nitriles. The catalytic results have indicated that the W-V-O nanostructures show excellent performance with yields of 2,4- and 2,6-dichlorobenzonitrile respectively reaching up to 77.3 and 75.1%, which are the highest among the previously reported catalysts with two components. The formation process of the urchinlike W-V-O microspheres was simply investigated.
Aerobic Oxidative Dehydrogenation of Amines Catalyzed by a Recoverable Ruthenium Catalyst under Mild Reaction Conditions
Karimi, Babak,Yari, Omolbanin,Khorasani, Mojtaba,Vali, Hojatollah,Mansouri, Fariborz
, p. 1783 - 1787 (2018/01/27)
A highly active catalyst based on perruthenate ions supported inside the channels of periodic mesoporous organosilica with a bridged imidazolium ionic liquid framework (Ru@PMO-IL) was developed. The material was found to be an efficient, durable, and recoverable catalyst for the oxidative dehydrogenation of various types of amines such as benzylic, aliphatic, and cyclic aliphatic amines under mild reaction conditions. The products were obtained in excellent yields with excellent selectivities.
NH3?H2O: The Simplest Nitrogen-Containing Ligand for Selective Aerobic Alcohol Oxidation to Aldehydes or Nitriles in Neat Water
Zhang, Guofu,Ma, Danting,Zhao, Yiyong,Zhang, Guihua,Mei, Guangyao,Lyu, Jinghui,Ding, Chengrong,Shan, Shang
, p. 885 - 889 (2018/12/10)
Aqueous ammonia (NH3?H2O) has been shown to serve as the simplest nitrogen-containing ligand to effectively promote copper-catalyzed selective alcohol oxidation under air in water. A series of alcohols with varying electronic and steric properties were selectively oxidized to aldehydes with up to 95 % yield. Notably, by increasing the amount of aqueous ammonia in neat water, the exclusive formation of aryl nitriles was also accomplished with good-to-excellent yields. Additionally, the catalytic system exhibits a high level of functional group tolerance with ?OH, ?NO2, esters, and heteroaryl groups all being amenable to the reaction conditions. This one-pot and green oxidation protocol provides an important synthetic route for the selective preparation of either aldehydes or nitriles from commercially available alcohols.
Metal-free HNO3/TEMPO-catalyzed conversion of benzyl alcohols to aromatic nitriles with oxygen molecule as the terminal oxidant
Zhao, Bo,Ren, Yun-Lai,Ren, Fangping,Tian, Xinzhe,Zhao, Shuang
supporting information, p. 627 - 632 (2019/05/01)
A non-metal catalytic method for the aerobic conversion of primary alcohols to aromatic nitriles via a single-step operation was developed. A series of primary benzyl alcohols underwent this transformation to give the targeted products in moderate to high yields under the catalysis of TEMPO/ HNO3.
A 4, 6 - double-halogenated isophthalonitrile preparation method (by machine translation)
-
, (2017/07/21)
The present invention relates to the technical field of the synthesis of pharmaceutical intermediates, in particular to a 4, 6 - double-halogenated isophthalonitrile preparation method, through the use of cheap and easily obtained 2, 4 - double-halo benzoic acid as the raw material, the reaction of the halide, the amidation reaction, dehydration reaction, the nitration reaction, reduction reaction, the diazotization reaction, the substitution reaction for the synthesis of 4, 6 - double-halogenated isophthalonitrile; the total yield can be 21.5%. The process route is easily obtained and cheap materials, few by-products, the purification treatment is the process is simple, easy to realize industrial production. (by machine translation)
Copper (II)-catalysed direct conversion of aldehydes into nitriles in acetonitrile
Ma, Xiaoyun,Ao, Jun,Chen, Zhengjian,Liu, Yi
, p. 465 - 468 (2017/08/18)
A mild one-pot method for the direct conversion of aryl, heteroaryl and alkyl aldehydes into nitriles was achieved by forming the corresponding oximes in situ with NH2OH and allowing them to react with CuO and acetonitrile. Yields of the 13 nitriles prepared were moderate to very good (62–91%).
