69045-83-6

Basic information

• Product Name: 2,3-Dichloro-5-(trichloromethyl)pyridine
• Synonyms: 2 3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDIN&;2,3-Dichloro-5-(trichloromethyl)pyridine;Pyridine,2,3-dichloro-5-(trichloromethyl)-
• CAS NO: 69045-83-6
• Molecular Formula: C₆H₂Cl₅N
• Molecular Weight: 265.35178
• EINECS: 1312995-182-4
• Product Categories: blocks;FluoroCompounds;Pyridines;Pyridine series
• Mol File: 69045-83-6.mol

Chemical Properties

• Boiling Point: 278-279 °C(lit.)
• Flash Point: 150 °F
• Appearance: /
• Density: 1.636 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00306mmHg at 25°C
• Refractive Index: n20/D 1.5900(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.03±0.10(Predicted)
• CAS DataBase Reference: 2,3-Dichloro-5-(trichloromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloro-5-(trichloromethyl)pyridine(69045-83-6)
• EPA Substance Registry System: 2,3-Dichloro-5-(trichloromethyl)pyridine(69045-83-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 69045-83-6(Hazardous Substances Data)

Usage

Uses

Used in Pesticide Industry:
2,3-Dichloro-5-(trichloromethyl)pyridine is used as an active ingredient in pesticides for its ability to control a broad spectrum of pests and insects. It is valued for its effectiveness in protecting crops and managing infestations in various agricultural settings.
Used in Chemical Synthesis:
In the chemical industry, 2,3-Dichloro-5-(trichloromethyl)pyridine serves as an intermediate in the synthesis of other chemicals. Its unique structure and reactivity make it a valuable component in the creation of various chemical products.
Safety Note:
Due to its highly toxic nature, 2,3-Dichloro-5-(trichloromethyl)pyridine must be handled with extreme care, adhering to stringent safety protocols to prevent exposure and potential harm to human health and the environment.

InChI:InChI=1/C6H2Cl5N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H

Upstream product

• 65550-81-4 2-bromo-3-chloro-5-methyl-pyridine 
• 108-99-6 3-Methylpyridine 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 54127-63-8 5-chloro-6-hydroxy-3-pyridinecarboxylic acid 
• 812-22-6 2,2,3,3,3-pentachloro-propionaldehyde 
• 107-13-1 acrylonitrile 
• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 
• 7440-33-7 tungsten 
• 3099-50-1 3-trichloromethyl-pyridine 
• 59-67-6 nicotinic acid 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 59782-90-0 2,3-dichloro-5-(methyl)pyridine 

Downstream Products

• 73265-15-3 3,5-dichloro-4-[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy]aniline 
• 71422-67-8 chlorfluazuron 
• 72537-17-8 2-fluoro-3-chloro-5-(trifluoromethyl)pyridine 
• 79622-59-6 fluazinam 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 54127-31-0 5-chloromethyl-2,3-dichloropyridine 
• 89570-82-1 3-chloro-5-(trifluoromethyl)-pyridin-2-yl-hydrazine 
• 89810-01-5 3-chloro-2-methylamine-5-trifluoromethylpyridine 
• 76041-74-2 3-chloro-5-(trifluoromethyl)pyridine-2-thiol 
• 76041-71-9 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine 
• 79456-26-1 2-amino-3-chloro-5-(trifluoromethyl)pyridine 

Relevant articles and documents

Synthesis method of 2, 3-dichloro-5-trichloromethylpyridine

The invention discloses a synthesis method of 2, 3-dichloro-5-trichloromethylpyridine, which is characterized in that a microreactor is used as a chlorination reaction channel, the first half of the microreactor channel is used as a primary chlorination channel, and the second half of the microreactor channel is filled with a catalyst B as a secondary chlorination reaction channel. The method comprises the following steps of firstly, fully mixing 2-chloro-5-methylpyridine with a catalyst A in a mixing chamber, then continuously reacting with chlorine through a primary chlorination channel to obtain 2-chloro-5-trichloromethylpyridine, then reacting through a secondary chlorination channel to obtain a crude oil layer of 2, 3-dichloro-5-trichloromethylpyridine, and carrying out alkali washing, dechlorination and rectification on the crude oil layer to obtain the high-concentration 2, 3 -dichloro-5-trichloromethylpyridine with the total yield to be 82-93%. According to the method, the technological process is simple, amplification production can be carried out through parallel connection, the catalyst B can be recycled and reused, the chlorination time is remarkably shortened, the chlorine utilization rate is increased, the post-treatment difficulty of the product is reduced, and the synthesis cost of 2, 3-dichloro-5-trichloromethylpyridine is saved.

Method for efficiently synthesizing pyridine chlorides

The invention discloses a method for efficiently synthesizing a pyridine chloride. The method comprises the following steps: introducing chlorine into methylpyridine in a solvent, and activating witha ligand catalyst; and after the activation is finished, separating and removing the solvent to obtain activated methylpyridine, carrying out a chlorine gas introduction reaction at a certain temperature, and after the reaction is finished, carrying out distillation separation to obtain 2,3-dichloro-5-trichloromethylpyridine. According to the process disclosed by the invention, methylpyridine is firstly activated by adopting an efficient ligand catalyst, then chlorine is introduced for chlorination, the chlorination process has high selectivity, the reaction condition is mild, the equipment operation is simple, few polychlorinated impurities are generated in the reaction process, and the process has high operability and economical efficiency.

Method for preparing 2, 3, 6-trichloropyridine

The invention discloses a preparation method of 2, 3, 6-trichloropyridine. The preparation method comprises the following steps: taking 3-methylpyridine and chlorine as raw materials and preparing 2,3, 6-trichloropyridine through catalytic one-step gas-phase chlorination and trichloromethyl removal by a molecular sieve catalyst in the presence of water vapor. The molecular sieve catalyst is prepared by taking raw molecular sieve powder as an active component. The raw material 3-methylpyridine adopted in the invention is a byproduct in the synthesis of pyridine by an aldehyde ammonia method, and the source is cheap and easy to obtain. The molecular sieve catalyst has strong treatment capacity, the 3-methylpyridine and the chlorine are used as the raw materials, a proper amount of water isadded, gas-phase chlorination and trichloromethyl removal reactions are carried out under the action of a molecular sieve acid center and water vapor molecules, and the 2, 3, 6-trichloropyridine is synthesized by one step. The process is simple, the product purity and conversion rate are high, the yield can be maintained at 85% or above generally, the maximum yield can reach up to 95%, and the preparation method of the 2, 3, 6-trichloropyridine has good industrial application prospect.

A 2 - chloro -5 - nitrapyrin preparation method

The invention discloses a 2 - chloro - 5 - trichloromethyl pyridine method, comprises the following steps: (1) the 3 - methyl pyridine is mixed with a solvent, the vaporization of the drops in the vaporization vessel, then in order to inert gas as a carrier gas, to form raw material steam; (2) dry Cl respectively2 The raw material and the steam is sent to the quartz tube catalyst [...] generating vapor phase chlorination reaction, reaction material after the condensation, rectification to obtain 2 - chloro - 5 - trichloromethyl pyridine. The invention relates to a 2 - chloro - 5 - trichloromethyl pyridine method, with raw materials are easy, low cost, easy to operate, simple process and the like.

Synthetic method of 2,3-dichloro-5-trichloromethyl pyridine

The invention provides a preparation method of 2,3-dichloro-5-trichloromethyl pyridine. The preparation method comprises the following steps: carrying out chlorination reaction on 2-chloro-5-chloromethyl pyridine and a chlorination reagent at 1-8 atm at the temperature of 100-250 DEG c in the presence of a catalyst, and distilling to obtain the 2,3-dichloro-5-trichloromethyl pyridine; the preparation method disclosed by the invention has the advantages that raw materials are cheap, the operation is simple, the post-treatment is convenient, the purity and the yield are relatively high, and large-scale industrial production can be carried out. The used catalyst is oxides, chlorides or chlorine oxides of manganese, iron, cobalt and ruthenium. No solvent is added, and the use amount of the catalyst is small. The mixed catalyst is used to avoid excessive use of a single expensive catalyst, and the catalyst can be recycled. Effective components in the residues can be extracted, and waste isavoided. The method disclosed by the invention has the advantages that the reaction window is wide, and the intermediate which is not completely converted can be distilled out and can be continuouslyused.

Preparation method of 2-fluorine-3-chlorine-5-trifluoromethylpyridine

The invention relates to the technical field of chemical synthesis, and in particular discloses a preparation method of 2-fluorine-3-chlorine-5-trifluoromethylpyridine. The preparation method of the 2-fluorine-3-chlorine-5-trifluoromethylpyridine is characterized by comprising the following steps: taking 2-chlorine-5-trichloromethylpyridine as a raw material, taking tungsten hexachloride as a catalyst, heating and introducing chlorine to perform chlorination reaction, thereby obtaining 2,3-dichloro-5-trichloromethylpyridine; putting the 2,3-dichloro-5-trichloromethylpyridine into a fluorination kettle, adding antimony pentafluoride and anhydrous hydrogen fluoride, stirring and heating to perform reaction, cooling after reaction, washing with water, layering, feeding to a rectification kettle, and performing reduced-pressure rectification, thereby preparing the 2-fluorine-3-chlorine-5-trifluoromethylpyridine. The process is reliable, the raw materials are sufficient in the market and easily available, and the preparation method of the 2-fluorine-3-chlorine-5-trifluoromethylpyridine is low in production cost, simple in operation, high in yield and favorable for large-scale production.

Synthesis method of chlorfluazuron and application of chlorfluazuron in insecticide preparation

The invention belongs to the technical field of pesticide preparations, particularly relates to a synthesis method of chlorfluazuron and further discloses an application of chlorfluazuron in insecticide preparation. According to the synthesis method of chlorfluazuron, chlorfluazuron is prepared from 2,3-dichloro-5-(trifluoromethyl)pyridine, 2,6-dichloro-4-aminophenol and 2,6-difluorobenzoyl isocyanate as synthetic raw materials and N,N-dimethylacetamide as a reaction solvent on the basis of a conventional synthesis route in the prior art; under the action of a ZSM molecular sieve based catalyst, not only can synthesis of chlorfluazuron be realized, but also a reaction can be performed with the same reaction solvent, so that the problem of complicated process caused by the fact that solvents are required to be recovered step by step during two-step synthesis of chlorfluazuron in the prior art is solved; compared with the technology in the prior art, the synthesis method of chlorfluazuron has the advantages that the synthesis yield of products is further increased and product content is higher.

2. 3 - dichloro -5 - trifluoro methyl pyridine preparation method

The invention provides a preparation method of 2,3-dichloro-5-trifluoromethylpyridine. The preparation method comprises the following steps: (a) 2-chloro-5-chloromethyl pyridine is provided; (b) in the presence of a catalyst, 2-chloro-5-chloromethyl pyridine from the step (a) and a chloride agent chlorine undergo a chlorination reaction so as to obtain 2,3-dichloro-5-trichloromethylpyridine, wherein the catalyst is oxide of copper, chloride of copper or a combination of the oxide of copper and the chloride of copper; (c) after heated and dissolved, 2,3-dichloro-5-trichloromethylpyridine obtained from the step (b) undergoes a fluoridation reaction with hydrogen fluoride under the action of a catalyst so as to obtain 2,3-dichloro-5-trifluoromethylpyridine, wherein the catalyst is oxide of antimony or halide of antimony. By the above method, production cost is reduced, conversion rate is raised, and toxicity is decreased.

A METHOD FOR PRODUCING 2,3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDINE

The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl as chlorinating agent at elevated temperature and pressure.

Vapor phase catalytic chlorination of ?-picoline

2-Chloro-5-trichloromethylpyridine is obtained by chlorinating β-picoline in the vapor phase using a Mordenite zeolite or a supported palladium catalyst.