10017-37-5

Basic information

• Product Name: 2-AMINO-2-METHYLPROPANE HYDROCHLORIDE
• Synonyms: TERT-BUTYLAMINE HYDROCHLORIDE;2-methyl-2-aminopropanehydrochloride;2-methyl-2-propanaminhydrochloride;tert-butylammoniumchloride;2-AMINO-2-METHYLPROPANE HYDROCHLORIDE;2-METHYL-2-PROPYLAMINE HYDROCHLORIDE;2-Amino-2-methylpropaneHCl;TRIBUTYLAMINEHYDROCHLORIDE
• CAS NO: 10017-37-5
• Molecular Formula: C4H12ClN
• Molecular Weight: 109.6
• EINECS: 233-009-5
• Mol File: 10017-37-5.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 44.4°Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 0.744g/cm³
• Vapor Pressure: 363mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 3905687
• CAS DataBase Reference: 2-AMINO-2-METHYLPROPANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-2-METHYLPROPANE HYDROCHLORIDE(10017-37-5)
• EPA Substance Registry System: 2-AMINO-2-METHYLPROPANE HYDROCHLORIDE(10017-37-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• RTECS: EO5201000
• F: 2-10-21
• Hazardous Substances Data: 10017-37-5(Hazardous Substances Data)

Usage

General Description

2-Amino-2-methylpropane hydrochloride, also known as tert-Leucine hydrochloride, is a chemical compound with the formula C5H12NCl. Its main feature is a tertiary amine and a functional group which includes a nitrogen atom. In its solid state, it appears as a white crystalline powder. This chemical is highly soluble in water and is often used in organic synthesis. Common uses of 2-amino-2-methylpropane hydrochloride include as an intermediate or reactant in pharmaceutical manufacturing and as a catalyst in various chemical reactions. Its toxicological properties are not well-known, and appropriate safety measures should be taken while handling this chemical.

InChI:InChI=1/C4H11N.ClH/c1-4(2,3)5;/h5H2,1-3H3;1H

Upstream product

• 2425-74-3 t-butylformamide 
• 13686-33-4 t-butyl azide 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 98-85-1 1-Phenylethanol 
• 108-88-3 toluene 
• 100-51-6 benzyl alcohol 
• 27189-32-8 N,N-di-tert-butylformamide 
• 925-90-6 ethylmagnesium bromide 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 75-64-9 tert-butylamine 
• 650-52-2 bis(trifluoromethyl)chlorophosphine 
• 119072-55-8 tert-butylisonitrile 
• 1121-60-4 pyridine-2-carbaldehyde 
• 107-15-3 ethylenediamine 

Downstream Products

• 7668-28-2 3-amino-1,2-benzisothiazole 1,1-dioxide 
• 7677-47-6 3-Methyl-amino-1,2-benzisothiazol-1,1-dioxid 
• 21995-76-6 benzyl N-[(tert-butylcarbamoyl)methyl]carbamate 
• 5894-65-5 N-t-butylbenzamide 
• 1320256-70-9 (E)-4-(4-bromophenyl)-N-(tert-butyl)-2-oxobut-3-enamide 
• 1320256-55-0 (E)-N-(tert-butyl)-4-(3-methoxyphenyl)-2-oxobut-3-enamide 
• 1320256-59-4 (E)-N-(tert-butyl)-4-(3,4-dimethoxyphenyl)-2-oxobut-3-enamide 
• 1320256-76-5 (E)-N-(tert-butyl)-4-(2-nitrophenyl)-2-oxobut-3-enamide 
• 1320256-72-1 (E)-N-(tert-butyl)-4-(4-nitrophenyl)-2-oxobut-3-enamide 
• 1320256-74-3 (E)-N-(tert-butyl)-4-(3-nitrophenyl)-2-oxobut-3-enamide 
• 1320256-65-2 (E)-N-(tert-butyl)-4-(4-fluorophenyl)-2-oxobut-3-enamide 
• 2849-81-2 N-t-butyl-p-toluenesulfonamide 
• 1118-12-3 1,1-dimethylethylurea 
• 7337-45-3 N-tert-butylaminoborane 

Relevant articles and documents

Di-tert-butyl Hyponitrite as a Source of Alkoxyl Radicals for Dimerization

-

Direct Preparation of Amides from Amine Hydrochloride Salts and Orthoesters: A Synthetic and Mechanistic Perspective

The conversion of a wide range of primary and secondary aliphatic and a few arylamine hydrochloride salts to their corresponding acetamides with trimethyl orthoacetate is described. Mechanistic studies using NMR and gas chromatography-mass spectrometry techniques indicate these reactions proceed via an O-methylimidate intermediate that undergoes in situ demethylation by chloride, affording the corresponding acetamides. Synthetically, this reaction represents a practical, high-yielding protocol with a simple workup for the rapid conversion of amine hydrochloride salts to acetamides.

Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals

Iron oxide (Fe3O4) nanocrystals generated in situ from an inexpensive and readily available iron source catalyze the reduction of nitroarenes to anilines with unparalleled efficiency. The procedure is chemoselective, avoids the use of precious metals, and can be applied under mild reflux conditions (65 or 80 C) or using sealed vessel microwave heating in an elevated temperature regime (150 C). Utilizing microwave conditions, a variety of functionalized anilines have been prepared in nearly quantitative yields within 2-8 min at 150 C, in a procedure also successfully applied to the reduction of aliphatic nitro compounds and azides. The iron oxide nanoparticles are generated in a colloidal form, resulting in homogeneous solutions suitable for continuous flow processing. Selected examples of anilines of industrial importance have been prepared in a continuous regime using this protocol.

Conversion of Amides to Amines using Iodosobenzene

-

Green method for catalyzing reduction reaction of aliphatic nitro derivative

The invention relates to a green method for catalyzing reduction reaction of aliphatic nitro derivatives. According to the method, non-transition metal compounds, namely triethyl boron and potassium tert-butoxide, are used as a catalytic system for the first time, an aliphatic nitro derivative and pinacolborane which is low in price and easy to obtain are catalyzed to be subjected to a reduction reaction under mild conditions, and an aliphatic amine hydrochloride product is synthesized after acidification with a hydrochloric acid aqueous solution. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective reduction reaction of the aliphatic nitro derivative catalyzed by the non-transition metal catalyst and pinacol borane is realized for the first time, and the aliphatic amine hydrochloride product is synthesized through acidification treatment of the hydrochloric acid aqueous solution, so that a practical new reaction strategy is provided for laboratory preparation or industrial production.