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1355049-94-3

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  • (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol CAS No.:1355049-94-3

    Cas No: 1355049-94-3

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  • Best Quality (3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]Triazin-7-yl)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-ol

    Cas No: 1355049-94-3

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  • (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dibenzyloxy-5-(benzyloxymethyl)tetrahydrofuran-2-ol

    Cas No: 1355049-94-3

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  • Cas no.1355049-94-3 98% D-Ribofuranose, 1-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)-

    Cas No: 1355049-94-3

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1355049-94-3 Usage

Description

(3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol is a complex organic compound characterized by a tetrahydrofuran backbone and a 4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl side chain. It features multiple benzyloxy and (benzyloxy)methyl groups attached to the tetrahydrofuran ring, and its specific orientation and stereochemistry are denoted by the (3R,4R,5R) designation, which indicates the chirality of the carbon atoms in the molecule. This unique structure and the presence of potential functional groups for modification or interaction with biological targets make it a compound of interest in medicinal chemistry or organic synthesis.

Uses

Used in Medicinal Chemistry:
(3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol is used as a potential pharmaceutical candidate for the development of new drugs. Its unique structure and functional groups may allow for targeted interactions with biological targets, such as enzymes or receptors, which could lead to the discovery of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (3R,4R,5R)-2-(4-aminopyrrole-[2,1-f][1,2,4]-triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-ol serves as a valuable intermediate or building block for the synthesis of more complex molecules. Its versatile structure and the presence of multiple functional groups make it a useful component in the construction of a wide range of organic compounds, including natural products, pharmaceuticals, and materials with specific properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1355049-94-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,5,0,4 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1355049-94:
(9*1)+(8*3)+(7*5)+(6*5)+(5*0)+(4*4)+(3*9)+(2*9)+(1*4)=163
163 % 10 = 3
So 1355049-94-3 is a valid CAS Registry Number.

1355049-94-3Downstream Products

1355049-94-3Relevant articles and documents

Continuous Flow C-Glycosylation via Metal-Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir

Kappe, C. Oliver,Von Keutz, Timo,Williams, Jason D.

, p. 2362 - 2368 (2020)

As remdesivir is the first approved treatment for COVID-19 (SARS-CoV-2), its production is likely to be of vital importance in the near future. Continuous flow processing has been demonstrated as a key technology in the manufacturing of high-volume active pharmaceutical ingredients and is considered for use in this synthetic sequence. In particular, the challenging C-glycosylation of a pyrrolotriazinamine via metal-halogen exchange was identified as a transformation with significant potential benefit, as exemplified by calorimetric analysis of each reaction step. Multiple simplifications of this process were attempted in batch but in general were found to be unfruitful. The five-feed process was then transferred to a flow setup, where specific conditions were found to circumvent solid formation and permit stable processing. Detailed optimization of stoichiometries provided an improvement upon batch conditions with a total residence time of 1 min.

Development of a Large-Scale Cyanation Process Using Continuous Flow Chemistry en Route to the Synthesis of Remdesivir

Badalov, Pavel,Chtchemelinine, Andrei,Gao, Detian,Heumann, Lars,Stevens, Andrew C.,Vieira, Tiago

, p. 2113 - 2121 (2020)

The implementation of cyanation chemistry at manufacturing scales using batch equipment can be challenging because of the hazardous nature of the reagents employed and the tight control of reaction parameters, including cryogenic temperatures, that help t

METHODS OF PREPARING 1'-CYANO NUCLEOSIDES

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Paragraph 0192; 0194, (2021/09/17)

The present disclosure generally describes methods of preparing l'-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (Il-a) in a flow reactor.

Compound containing guanidyl group, and preparation method and application thereof

-

, (2021/08/07)

The invention provides a preparation containing a guanidino compound and used for treating pneumoviridae virus infection, a method, a compound of a formula I, and a method and an intermediate for synthesizing the compound of the formula I.

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