1622-32-8

Basic information

• Product Name: 2-CHLOROETHANESULFONYL CHLORIDE
• Synonyms: 2-Chloroethane-1-sulfonic acid chloride;2-Chloroethanesulfonic acid chloride;2-Chloroethanesulfonyl Chloride, 95.0%(GC&T;2-CHLOROETHANESULFONYL CHLORIDE;2-CHLOROETHANESULPHONYL CHLORIDE;2-CHLORO-1-ETHANESULFONYL CHLORIDE;2-chloroethanesulfochloride;2-chloroethanesulfochloride[qr]
• CAS NO: 1622-32-8
• Molecular Formula: C₂H₄Cl₂O₂S
• Molecular Weight: 163.02
• EINECS: 216-594-1
• Product Categories: Protecting and Derivatizing Reagents;Protection and Derivatization;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Others
• Mol File: 1622-32-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 3 °C
• Boiling Point: 84-86 °C15 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear slightly yellow to brown/Liquid
• Density: 1.56 g/mL at 25 °C(lit.)
• Vapor Pressure: 15 mm Hg ( 84 °C)
• Refractive Index: n20/D 1.493(lit.)
• Storage Temp.: Refrigerator
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 1751202
• CAS DataBase Reference: 2-CHLOROETHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROETHANESULFONYL CHLORIDE(1622-32-8)
• EPA Substance Registry System: 2-CHLOROETHANESULFONYL CHLORIDE(1622-32-8)

Safety Data

• Hazard Codes: T+
• Statements: 22-26-34-36
• Safety Statements: 26-28-36/37/39-45-23
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 3
• RTECS: KI8060000
• F: 10-19
• TSCA: Y
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1622-32-8(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR SLIGHTLY YELLOW TO BROWN LIQUID

Uses

2-Chloroethanesulfonyl chloride was used in one-pot sulfonylation/intramolecular thia-Michael protocol for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. It was also used in synthesis of vinyl sulfonamides with a furan, carbocyclic, semi cyclic or acyclic 1,3-diene moiety.

General Description

A liquid. Density 1.56 g / cm3. Flash point exceeds 230°F.

Air & Water Reactions

Reacts with water to produce corrosive and toxic gaseous hydrogen chloride.

Reactivity Profile

2-CHLOROETHANESULFONYL CHLORIDE is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

InChI:InChI=1/C2H4Cl2O2S/c3-1-2-7(4,5)6/h1-2H2

Upstream product

• 75-00-3 chloroethane 
• 26650-04-4 2-chloroethyl sulfenyl chloride 
• 928-57-4 2-chloroethyl thiocyanate 
• 594-44-5 Ethanesulfonyl chloride 
• 107-07-3 2-chloro-ethanol 
• 60-24-2 2-hydroxyethanethiol 
• 7647-01-0 hydrogenchloride 
• 111-48-8 2,2'-thiobis-ethanol 
• 7782-50-5 chlorine 
• 505-60-2 bis (2-chloroethyl) sulphide 
• 7732-18-5 water 
• 107-36-8 2-hydroxyethanesulfonic acid 
• 870-24-6 2-chloroethanamine hydrochloride 
• 1562-00-1 sodium 2-hydroxyethanesulfonate 

Downstream Products

• 1562-31-8 Vinyl sulfonic acid methyl ester 
• 92352-37-9 ethenesulfonic acid-(4-nitro-anilide) 
• 71365-70-3 2-(dimethylamino)ethane-1-sulfonamide 
• 1562-34-1 phenyl vinylsulfonate 
• 3058-66-0 4-chloro-3-methylphenyl ethenesulfonate 
• 1562-32-9 Vinylsulfonsaeure-(pentachlorphenylester) 
• 3058-61-5 4-tolyl ethenesulfonate 
• 2546-42-1 4-fluorophenyl ethenesulfonate 
• 3058-83-1 3-chlorophenyl ethenesulfonate 
• 3058-67-1 4-(tert-butyl)phenyl vinylsulfonate 
• 2837-27-6 Vinylsulfonsaeure-(2-fluor-phenylester) 
• 6855-40-9 Vinylsulfonsaeure-<2-brom-phenylester> 
• 4790-38-9 Ethenesulfonic acid 4-chloro-2-methylphenyl ester 
• 6860-75-9 Vinylsulfonsaeure-(4-thiocyanato-phenylester) 

Relevant articles and documents

A sulfonamidoquinoline-derived Zn2+ fluorescent sensor with 1:1 Zn2+ binding stoichiometry

The integration of bis(pyridin-2-ylmethyl)amine (BPA) with 8-sulfonamidoquinoline (SQ) resulted in a new fluorescent Zn2+ sensor of 1:1 binding stoichiometry. The synergic Zn2+ coordination of BPA and SQ motifs provides the sensor the advantage over TSQ and its analogues in discriminating mobile Zn2+ from the bound Zn2+ of unoccupied coordination sites in living systems. Its pH-independent Zn 2+-enhanced emission in physiological condition and cell permeability make it an effective intracellular Zn2+ imaging agent. This sensor profits also from its confirmed Golgi-preferential affinity, and its pH-independent Zn2+ response in physiological pH range provides it the advantages over other xanthenone-based sensors.

Iridinesulfonamide compound and use method thereof

An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation-induced cancers.

PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE

The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof.