2482-00-0 Usage
Uses
Used in Pharmaceutical Industry:
Agmatine sulfate is used as a neuromodulator for its ability to displace clonidine at α2-adrenergic and imidazoline receptors, exerting neuroprotective effects and blocking NMDA-receptor associated cation channels. It is also a competitive inhibitor of nitric oxide synthase activity, mimicking the natural NOS substrate arginine.
Used in Research Applications:
Agmatine sulfate is used as a research compound for studying its interactions with various molecular targets and its potential role in neurotransmission, pain management, and neuroprotection.
Used in Nutritional Supplements:
Agmatine sulfate is used as a dietary supplement for its potential cognitive, vascular, and athletic performance benefits, as well as its possible role in pain relief and neuroprotection.
Chemical Properties:
Agmatine sulfate is a white to off-white powder.
General Uses
Neuroprotective, CNS studies, Autism and depression research
Description: Agmatine Sulfate is a polyamine derived from L-arginine decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats and reverses depressive like behavior in mice.
Biological Activity
Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.
Biochem/physiol Actions
Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α2-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.
Purification Methods
Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]
References
Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.
Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine
Check Digit Verification of cas no
The CAS Registry Mumber 2482-00-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2482-00:
(6*2)+(5*4)+(4*8)+(3*2)+(2*0)+(1*0)=70
70 % 10 = 0
So 2482-00-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
2482-00-0Relevant articles and documents
PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
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, (2010/03/02)
The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.
Production process for a guanidine derivative containing an amido group and for a salt thereof
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, (2008/06/13)
A guanidine derivative containing an amido group, represented by is produced by reacting a guanidine derivative containing an amino group represented by with a fatty acid halide or a fatty acid ester.
