2857-97-8Relevant articles and documents
Redistribution equilibria of substituents between the methyl- and trimethylsilicon moieties
Moedritzer, Kurt,Van Wazer, John R.
, p. 1254 - 1257 (1966)
Scrambling equilibria resulting from the exchange of pairs of monofunctional substituents (halogen, methoxyl, methylthio, and dimethylamino) between the methyl- and trimethylsilicon moieties have been studied by proton nuclear magnetic resonance. Unexpect
Evers et al.
, p. 239,240 (1960)
The First Gallium-Arsenic Compound containing a Single Ga3As Unit: Isolation and Crystal Structure of 3As (thf=tetrahydrofuran)
Wells, Richard L.,Shafieezad, Soheila,McPhail, Andrew T.,Pitt, Colin G.
, p. 1823 - 1824 (1987)
3As (thf=tetrahydrofuran), isolated from the products of the reaction of (Me3Si)3As with GaBr3, has been shown by X-ray crystallographic analysis to be the first example of a compound containing a single Ga3As unit.
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Eaborn, C. E.
, p. 685 - 686 (1950)
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C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor
Dixon, Darryl D.,Tius, Marcus A.,Thakur, Ganesh A.,Zhou, Han,Bowman, Anna L.,Shukla, Vidyanand G.,Peng, Yan,Makriyannis, Alexandros
supporting information; experimental part, p. 5322 - 5325 (2012/09/07)
A series of tricyclic cannabinoids incorporating a heteroaroyl group at C3 were prepared as probes to explore the binding site(s) of the CB1 and CB2 receptors. This relatively unexplored structural motif is shown to be CB2 selective with Ki values at low nanomolar concentrations when the heteroaromatic group is 3-benzothiophenyl (41) or 3-indolyl (50). When photoactivated, the lead compound 41 was shown to successfully label the CB2 receptor through covalent attachment at the active site while 50 failed to label. The benzothiophenone moiety may be a photoactivatable moiety suitable for selective labeling.
An efficient large-scale synthesis of gemcitabine employing a crystalline 2, 2-difluoro-α-ribofuranosyl bromide
Chang, Young-Kil,Lee, Jaeheon,Park, Gha-Seung,Lee, Moonsub,Park, Chul Hyun,Kim, Han Kyong,Lee, Gwansun,Lee, Bo-Young,Baek, Ju Yuel,Kim, Kwan Soo
experimental part, p. 5687 - 5691 (2010/09/18)
An efficient large-scale synthesis of gemcitabine was achieved without chromatography or fractional crystallization. The key steps include stereospecific conversion of a novel β-ribofuranosyl phosphate into a highly crystalline a-ribofuranosyl bromide and coupling of the α-ribofuranosyl bromide and trime- thylsilyl cytosine to produce a β-nucleoside. p-Phenylbenzoyl group was introduced for the protection of one of hydroxy groups in order to enhance the crystallinity of intermediates. Continuous removal of trimethylsilyl bromide, generated during the coupling reaction, by distillation from the reaction medium substantially enhanced the β-selectivity of the crucial coupling reaction.