352-34-1

Basic information

• Product Name: 1-Fluoro-4-iodobenzene
• Synonyms: 4-FLUORO-1-IODOBENZENE;4-FLUOROIODOBENZENE;1-FLUORO-4-IODOBENZENE;P-FLUOROIODOBENZENE;1-fluoro-4-iodo-benzen;4-Iodofluorobenzene;p-Iodofluorobenzene;4-FLUOROIODOBENZENE 98% (GC)
• CAS NO: 352-34-1
• Molecular Formula: C₆H₄FI
• Molecular Weight: 222
• EINECS: 206-522-7
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Miscellaneous;Fluorine Compounds;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons;alkyl Iodine| alkyl Fluorine;Pyridines ,Halogenated Heterocycles
• Mol File: 352-34-1.mol
• Article Data: 52

Chemical Properties

• Melting Point: −20 °C(lit.)
• Boiling Point: 182-184 °C(lit.)
• Flash Point: 155 °F
• Appearance: Clear yellow/Liquid
• Density: 1.925 g/mL at 25 °C(lit.)
• Vapor Pressure: 9.94E-16mmHg at 25°C
• Refractive Index: n20/D 1.583(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• BRN: 1853970
• CAS DataBase Reference: 1-Fluoro-4-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-4-iodobenzene(352-34-1)
• EPA Substance Registry System: 1-Fluoro-4-iodobenzene(352-34-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-2637/39
• RIDADR: UN2810
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 352-34-1(Hazardous Substances Data)

Usage

Description

4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

Chemical Properties

colorless to light yellow liquid

Uses

Different sources of media describe the Uses of 352-34-1 differently. You can refer to the following data:
1. suzuki reaction
2. 4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives. 4-[F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions.
3. 4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives.

General Description

4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

InChI:InChI=1/C25H20F3NO4/c26-25(27,28)21-12-6-1-7-15(21)13-22(23(30)31)29-24(32)33-14-20-18-10-4-2-8-16(18)17-9-3-5-11-19(17)20/h1-12,20,22H,13-14H2,(H,29,32)(H,30,31)

Upstream product

• 462-06-6 fluorobenzene 
• 1514-50-7 4-iodobenzenediazonium tetrafluoroborate 
• 108-95-2 phenol 
• 7647-01-0 hydrogenchloride 
• 371-40-4 4-fluoroaniline 
• 67-56-1 methanol 
• 7790-99-0 Iodine monochloride 
• 56-23-5 tetrachloromethane 
• 7553-56-2 iodine 
• 616-47-7 1-methyl-1H-imidazole 
• 99506-39-5 4-fluorophenyl(m-carboran-9-yl)iodonium tetrafluoroborate 
• 7681-49-4 sodium fluoride 
• 5122-99-6 4-iodophenylboronic acid 
• 73852-88-7 2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 64634-57-7 di(p-tolyl)(4-fluorophenyl)amine 
• 56285-84-8 1-Fluoro-4-(2,2,2-trifluoro-1-methoxy-1-trifluoromethyl-ethylsulfanyl)-benzene 
• 120866-17-3 4-fluoro-1-iodosylbenzene 
• 30101-16-7 (4-fluorophenyl)diiodoborane 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 70445-94-2 1-(4-fluorophenyl)-3,3-dimethylbutan-2-one 
• 310-40-7 diethyl (4-fluorophenyl)phosphonate 
• 138900-17-1 1-(4-fluorophenyl)-5-nitro-1H-indole 
• 130995-12-9 1-(4-fluorophenyl)-2-trimethylsilylacetylene 
• 10540-41-7 4'-fluoro-[1,1'-biphenyl]-3-ol 
• 324-94-7 4'-fluoro-biphenyl-4-ol 
• 80254-62-2 4'-fluoro-[1,1'-biphenyl]-2-ol 
• 16308-15-9 (4-fluorophenyl)-λ³-iodanediyl diacetate 
• 1682-50-4 1-(Dichloriod)-4-fluorbenzol 

Relevant articles and documents

PERFLUOROPOLYMER-SUPPORTED FITS REAGENTS

Perfluoropolymer-supported FITS reagents (FITS-Nafion) were synthesized by treatment of bis(trifluoroacetoxy)iodoperfluoroalkenes with perfluorosulfonic acid resin (Nafion-H) and benzene or fluorobenzene.

Selective C-H Iodination of (Hetero)arenes

Iodoarenes are versatile intermediates and common synthetic targets in organic synthesis. Here, we present a strategy for selective C-H iodination of (hetero)arenes with a broad functional group tolerance. We demonstrate the utility and differentiation to other iodination methods of supposed sulfonyl hypoiodites for a set of carboarenes and heteroarenes.

A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents

A series of aryldifluoromethyl pyrimidine compounds containing strobilurin were synthesized through bioelectronic isometric design with azoxystrobin as the lead compound and a convenient approach to aryldifluoromethylpyrimidine intermediates was developed, which features mild reaction conditions and simple operation. The title compounds and aryldifluoromethylpyrimidine intermediates were characterized by NMR and HRMS. Both 7c and 7l of the preliminary screening tests showed 100% inhibition against Mythimna separata at 100 mg/L. At 20 mg/L, the lethal rate of 7l against Mythimna separata can be up to 80%.

Synthesis of biaryl compounds via Suzuki homocoupling reactions catalyzed by metal organic frameworks encapsulated with palladium nanoparticles

Heterogeneous homocoupling reactions of phenylboronic acids were greatly accelerated via Suzuki homocoupling reactions. In this work, a tandem route was designed which firstly one part of phenylboronic acids reacted with iodine to form iodobenzenes, then another part of phenylboronic acids coupled with iodobenzenes to produce biaryl compounds. The tandem reaction were catalyzed by a bifunctional heterogeneous catalyst of metal organic frameworks encapsulated with palladium nanoparticles (Pd?MOFs). This strategy for forming symmetric C-C bond between benzene rings has obvious advantages such as high efficiency, easy separation, good recyclability and no addition of toxic halogenated benzene.