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52462-29-0

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  • High Quality Oled CAS 52462-29-0 Ruthenium, di-m-chlorodichlorobis[(1,2,3,4,5,6-h)-1-methyl-4-(1-methylethyl)benzene]di-

    Cas No: 52462-29-0

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52462-29-0 Usage

Chemical Properties

red-orange to red-brown crystals or powder

Uses

Different sources of media describe the Uses of 52462-29-0 differently. You can refer to the following data:
1. Hydrosilylation Catalysts Umicore Precatalysts for Asymmetric and Cross-Coupling Catalysis Cyclometalated ruthenium complexes with arylimines and nitrogen-containing heterocycles via C-H bond activation
2. Dichloro(p-cymene)ruthenium(II) dimer is used as hydrosilylation catalyst and also used as a pharmaceutical intermediate.

General Description

This product has been enhanced for catalytic efficiency.

Check Digit Verification of cas no

The CAS Registry Mumber 52462-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,6 and 2 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52462-29:
(7*5)+(6*2)+(5*4)+(4*6)+(3*2)+(2*2)+(1*9)=110
110 % 10 = 0
So 52462-29-0 is a valid CAS Registry Number.
InChI:InChI=1/2C10H14.4ClH.2Ru/c2*1-8(2)10-6-4-9(3)5-7-10;;;;;;/h2*4-8H,1-3H3;4*1H;;/q;;;;;;2*+2/p-4

52462-29-0 Well-known Company Product Price

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  • TCI America

  • (D2751)  Dichloro(p-cymene)ruthenium(II) Dimer  >95.0%(T)

  • 52462-29-0

  • 1g

  • 635.00CNY

  • Detail
  • TCI America

  • (D2751)  Dichloro(p-cymene)ruthenium(II) Dimer  >95.0%(T)

  • 52462-29-0

  • 5g

  • 1,950.00CNY

  • Detail
  • Alfa Aesar

  • (L19126)  Dichloro(p-cymene)ruthenium(II) dimer, 98%   

  • 52462-29-0

  • 500mg

  • 235.0CNY

  • Detail
  • Alfa Aesar

  • (L19126)  Dichloro(p-cymene)ruthenium(II) dimer, 98%   

  • 52462-29-0

  • 2g

  • 688.0CNY

  • Detail
  • Alfa Aesar

  • (L19126)  Dichloro(p-cymene)ruthenium(II) dimer, 98%   

  • 52462-29-0

  • 10g

  • 3272.0CNY

  • Detail
  • Aldrich

  • (343706)  Dichloro(p-cymene)ruthenium(II)dimer  

  • 52462-29-0

  • 343706-1G

  • 758.16CNY

  • Detail
  • Aldrich

  • (343706)  Dichloro(p-cymene)ruthenium(II)dimer  

  • 52462-29-0

  • 343706-5G

  • 2,248.74CNY

  • Detail
  • Aldrich

  • (683213)  Dichloro(p-cymene)ruthenium(II)dimer  97%

  • 52462-29-0

  • 683213-500MG

  • 465.66CNY

  • Detail
  • Aldrich

  • (683213)  Dichloro(p-cymene)ruthenium(II)dimer  97%

  • 52462-29-0

  • 683213-2G

  • 1,115.01CNY

  • Detail

52462-29-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Dichloro(p-cymene)ruthenium(II) dimer

1.2 Other means of identification

Product number -
Other names Dichloro(p-cymene)ruthenium(II)dimer

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52462-29-0 SDS

52462-29-0Synthetic route

rhodium(III) chloride hydrate

rhodium(III) chloride hydrate

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene
4221-98-1

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In methanol at 140℃; for 0.166667h; Microwave irradiation;100%
In ethanol at 130℃; for 0.0666667h; Microwave irradiation;83%
In ethanol for 24h; Reflux;76%
4-methylisopropylbenzene
99-87-6

4-methylisopropylbenzene

ruthenium(III) chloride hydrate

ruthenium(III) chloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In 2-methoxy-ethanol; water at 120℃; for 4h; Product distribution / selectivity;98%
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

rhodium(III) chloride hydrate

rhodium(III) chloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 17h; Schlenk technique; Reflux; Inert atmosphere;98%
In ethanol for 4h; Reflux; Inert atmosphere;78%
In methanol Inert atmosphere; Schlenk technique; Heating;
In ethanol for 12h; Reflux; Inert atmosphere;
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium(III) chloride trihydrate

ruthenium(III) chloride trihydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 8h; Reflux;96%
In methanol for 4h; Schlenk technique; Inert atmosphere; Reflux;85%
ruthenium trichloride

ruthenium trichloride

4-methylisopropylbenzene
99-87-6

4-methylisopropylbenzene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
for 15h; Inert atmosphere; Reflux;94%
In butan-1-ol at 80℃; for 6h; Solvent; Temperature;94%
In ethanol Reflux;
ruthenium(III) chloride hydrate
20759-14-2

ruthenium(III) chloride hydrate

crithmene
99-85-4

crithmene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol RuCl3*H2O is refluxed in EtOH in presence of the cyclohexadiene under N2 (4 h); ppt. is filtered, a second crop of ppt. is obtained by reducing the filtrate and cooling (-10°C);90%
4-methylisopropylbenzene
99-87-6

4-methylisopropylbenzene

ruthenium(III) chloride trihydrate

ruthenium(III) chloride trihydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 24h; Solvent; Inert atmosphere; Reflux;90%
In ethanol for 24h; Reflux; Inert atmosphere;90%
1-methyl-4-isopropyl-1,3-cyclohexadiene
99-86-5

1-methyl-4-isopropyl-1,3-cyclohexadiene

rhodium(III) chloride hydrate

rhodium(III) chloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In methanol at 140℃; for 0.00833333h; Inert atmosphere; Microwave irradiation;86%
In methanol Schlenk technique; Inert atmosphere; Reflux;
In ethanol at 20℃; for 15h; Schlenk technique;
ruthenium(III) chloride hydrate
20759-14-2

ruthenium(III) chloride hydrate

1-methyl-4-isopropyl-1,3-cyclohexadiene
99-86-5

1-methyl-4-isopropyl-1,3-cyclohexadiene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol refluxing for 4 h; crystn. on cooling, filtration, washing (cold MeOH), drying (vac.); second crop on crystn. of filtrate after evapn.; elem. anal.;77%
ruthenium trichloride

ruthenium trichloride

p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 4h; Sonication; Reflux;76%
In ethanol at 79℃; for 4h; Heating / reflux;35%
Inert atmosphere; Schlenk technique;
Inert atmosphere; Schlenk technique;
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium trichloride hydrate

ruthenium trichloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol in a modified reflux microwave apparatus RuCl3 reacts with α-phellandrene in EtOH (react. time: 10 min);67%
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium(III)chloride
10049-08-8

ruthenium(III)chloride

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol other Radiation; to EtOH added RuCl3 and excess p-mentha-1,5-diene; soln. refluxed under microwave irradiation for 15 min; after cooling to room temp. solvent removed under vac.; residue washed with ether, complex collected by filteration, washed withether and dried; elem. anal.;65%
RuCl3 treated with α-phellandrene in according with early published method (M.A. Bennet, G.B. Robertson, A.K. Smith, J. Organomet. Chem. 43 (1972) C41);
ruthenium trichloride

ruthenium trichloride

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene
4221-98-1

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
Stage #1: ruthenium trichloride In ethanol for 8h; Reflux;
Stage #2: (R)-5-isopropyl-2-methylcyclohexa-1,3-diene In ethanol at 20℃; for 12h;
65%
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium trichloride hydrate

ruthenium trichloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol reflux overnight, under N2; ppt. was filtered off, washed with MeOH, dried in vac.;63.5%
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium(III) chloride tetrahydrate

ruthenium(III) chloride tetrahydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 24h; Schlenk technique; Reflux;62%
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
With ruthenium(III) trichloride hydrate In ethanol for 4h; Reflux; Inert atmosphere;11%
ruthenium trichloride hydrate

ruthenium trichloride hydrate

1-methyl-4-isopropyl-1,3-cyclohexadiene
99-86-5

1-methyl-4-isopropyl-1,3-cyclohexadiene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In not given according to: S. B. Jensen, S. J. Rodger, M. D. Spicer, J. Organomet. Chem. 556 (1998) 151;
Ru2Cl(μ-Cl)2(η6-p-cymene)2(1+)

Ru2Cl(μ-Cl)2(η6-p-cymene)2(1+)

chloride
16887-00-6

chloride

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In tetrahydrofuran Electrochem. Process; electrochemically generated Ru-complex-ion (voltammetric step), Ar atmosphere, supporting electrolyte 0.2 M Bu4NPF6; not isolated; voltammetric monitoring;
{(η6-p-cymene)ruthenium(η4-MeNC4Me4-H)} triflate

{(η6-p-cymene)ruthenium(η4-MeNC4Me4-H)} triflate

A

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

B

{CH3NC4H3(CH3)4}(1+)
153147-75-2

{CH3NC4H3(CH3)4}(1+)

Conditions
ConditionsYield
With HCl In dichloromethane under N2, standard Schlenk techniques; degassing a soln. of Ru-compd.in CH2Cl2 via three freeze/pump/thaw cycles, addn. of 1.6 equiv. HCl and stirring for 9 h; in air; evapn. of solvent, NMR;
[(RuCl2(p-cymene))2(μ-1,2-bis(ethylsulfinyl)ethane)]
658044-13-4

[(RuCl2(p-cymene))2(μ-1,2-bis(ethylsulfinyl)ethane)]

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In chloroform-d1 byproducts: EtS(O)C2H4S(O)Et; Ru complex was dissolved in CDCl3; NMR monitoring;
((11bS(a))-N,N-bis[(1R)-1-(naphthalen-1-yl)ethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine-κP4)-dichloro[η6-1-methyl-4-(1-methylethyl)benzene]ruthenium

((11bS(a))-N,N-bis[(1R)-1-(naphthalen-1-yl)ethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine-κP4)-dichloro[η6-1-methyl-4-(1-methylethyl)benzene]ruthenium

A

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

B

(S(α),S(Ru),R(C),R(C))-O,O'-(1,1'-dinaphthyl-2,2'-diyl)-N,N-bis(1-(1-naphthyl)ethyl)phosphoramidite

(S(α),S(Ru),R(C),R(C))-O,O'-(1,1'-dinaphthyl-2,2'-diyl)-N,N-bis(1-(1-naphthyl)ethyl)phosphoramidite

Conditions
ConditionsYield
In dichloromethane-d2 equil. in soln.; not isolated, detected by NMR;
[(RuCl2(p-cymene))2(μ-1,3-bis(ethylsulfinyl)propane)]
658044-14-5

[(RuCl2(p-cymene))2(μ-1,3-bis(ethylsulfinyl)propane)]

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In chloroform-d1 byproducts: EtS(O)C2H4S(O)Et; Ru complex was dissolved in CDCl3; NMR monitoring;
[RuCl2(p-cymene)(SOCCN(Mes)CH=CHN(Mes))]
1346137-04-9

[RuCl2(p-cymene)(SOCCN(Mes)CH=CHN(Mes))]

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In dichloromethane-d2 byproducts: SOCCN(Mes)CH=CHN(Mes); (N2); std. Schlenk technique; soln. of Ru complex in CD2Cl2 was heated at 40°C for few h; NMR monitoring;
1-methyl-4-isopropyl-1,3-cyclohexadiene
99-86-5

1-methyl-4-isopropyl-1,3-cyclohexadiene

ruthenium(III) chloride trihydrate

ruthenium(III) chloride trihydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 6h; Reflux;
In ethanol for 6h; Reflux;
In ethanol for 6h; Reflux;
rhodium(III) chloride hydrate

rhodium(III) chloride hydrate

crithmene
99-85-4

crithmene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 6h; Reflux;
In ethanol for 6h; Reflux;
In ethanol for 6h; Reflux;
ruthenium(III) trichloride hydrate

ruthenium(III) trichloride hydrate

crithmene
99-85-4

crithmene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol for 6h; Concentration; Reflux;
ruthenium(III) chloride trihydrate

ruthenium(III) chloride trihydrate

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene
4221-98-1

(R)-5-isopropyl-2-methylcyclohexa-1,3-diene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In methanol for 5h; Reflux; Inert atmosphere; Schlenk technique;
In methanol Inert atmosphere;
ruthenium trichloride

ruthenium trichloride

1-methyl-4-isopropyl-1,3-cyclohexadiene
99-86-5

1-methyl-4-isopropyl-1,3-cyclohexadiene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
at 50℃; for 0.5h; Microwave irradiation;
In methanol Reflux;
ruthenium(III) chloride trihydrate

ruthenium(III) chloride trihydrate

crithmene
99-85-4

crithmene

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol at 80 - 85℃; for 12h;1.85 g
In ethanol at 80℃; for 24h; Inert atmosphere;
p-mentha-1,5-diene
99-83-2

p-mentha-1,5-diene

ruthenium(III) trichloride hydrate

ruthenium(III) trichloride hydrate

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Conditions
ConditionsYield
In ethanol at 90 - 130℃;
In ethanol Inert atmosphere; Reflux;
1,2-bis(2,5-diphenylphospholano)methane
933474-81-8

1,2-bis(2,5-diphenylphospholano)methane

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

chloro-{1,2-bis[(R,R)-2,5-diphenylphospholano]methane}(p-cymene)ruthenium(II) chloride

chloro-{1,2-bis[(R,R)-2,5-diphenylphospholano]methane}(p-cymene)ruthenium(II) chloride

Conditions
ConditionsYield
In ethanol; dichloromethane at 70℃; for 2h;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

sodium acetylacetonate
15435-71-9, 1118-67-8

sodium acetylacetonate

(η(6)-p-cymene)Ru(acac)Cl

(η(6)-p-cymene)Ru(acac)Cl

Conditions
ConditionsYield
In acetone for 0.666667h; Inert atmosphere; Schlenk technique;100%
In acetone at 20℃; for 0.833333h;59%
(+)-(R)-2,2'bis(di-para-tolylphosphanyl)-1,1'binaphthyl
153305-67-0, 100165-88-6, 99646-28-3

(+)-(R)-2,2'bis(di-para-tolylphosphanyl)-1,1'binaphthyl

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

diethyl amine hydrochloride
660-68-4

diethyl amine hydrochloride

(RuCl(CH3C6H4)2PC10H6C10H6P(CH3C6H4)2)2Cl3(1-)*(CH3CH2)2NH2(1+)=[(RuCl(CH3C6H4)2PC10H6C10H6P(CH3C6H4)2)2Cl3](CH3CH2)2NH2

(RuCl(CH3C6H4)2PC10H6C10H6P(CH3C6H4)2)2Cl3(1-)*(CH3CH2)2NH2(1+)=[(RuCl(CH3C6H4)2PC10H6C10H6P(CH3C6H4)2)2Cl3](CH3CH2)2NH2

Conditions
ConditionsYield
In toluene (Ar); heating a soln. of ruthenium complex with ammonium salt and phosphine in toluene at 50°C for 2 h with stirring, refluxing for 12 hwith stirring; cooling, evapn.;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

Hg(C6H2-2,3-(OCH2O)-6-CH2NMe2)2
167031-63-2

Hg(C6H2-2,3-(OCH2O)-6-CH2NMe2)2

[(η(6)-1-Me-4-(i)Pr-C6H4)Ru(C6H3-2,3-(OCH2O)-6-CH2NMe2)Cl]
181468-51-9

[(η(6)-1-Me-4-(i)Pr-C6H4)Ru(C6H3-2,3-(OCH2O)-6-CH2NMe2)Cl]

Conditions
ConditionsYield
In dichloromethane byproducts: HgCl2; N2-atmosphere; stirring equimolar amts. at room temp. for 3 d; filtration off of HgCl2, concn., pptn. on Et2O addn.; elem. anal.;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

[η5-C5H4(CH2)2PPh2]Ti(O(i)Pr)3
847153-87-1

[η5-C5H4(CH2)2PPh2]Ti(O(i)Pr)3

(p-cymene)[(μ-η5:η1-C5H4(CH2)2PPh2)Ti(O(i)Pr)3]RuCl2

(p-cymene)[(μ-η5:η1-C5H4(CH2)2PPh2)Ti(O(i)Pr)3]RuCl2

Conditions
ConditionsYield
In dichloromethane (Ar); stirring a mixt. of ruthenium and titanium complexes in CH2Cl2 for4 h at room temp.; evapn., washing with pentane; elem. anal.;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

[η5-C5H4(CH2)2PCy2]Ti(O(i)Pr)3
847153-88-2

[η5-C5H4(CH2)2PCy2]Ti(O(i)Pr)3

(p-cymene)[(μ-η5:η1-C5H4(CH2)2PCy2)Ti(O(i)Pr)3]RuCl2

(p-cymene)[(μ-η5:η1-C5H4(CH2)2PCy2)Ti(O(i)Pr)3]RuCl2

Conditions
ConditionsYield
In dichloromethane (Ar); stirring a mixt. of ruthenium and titanium complexes in CH2Cl2 for4 h at room temp.; evapn., washing with pentane; elem. anal.;100%
1,10-Phenanthroline
66-71-7

1,10-Phenanthroline

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

chloro(p-cymene)(η2-1,10-phenanthroline-κ2N)ruthenium
861392-78-1

chloro(p-cymene)(η2-1,10-phenanthroline-κ2N)ruthenium

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h; Inert atmosphere; Schlenk technique;100%
In dichloromethane inert atm.; 2 equiv of phenanthroline was added to a suspn. of complex in CH2Cl2, the mixt. was stirred for 3 h at room temp.; evapd. to dryness, dissolved in water, filtered, evapd. to dryness; elem. anal.;99%
In methanol for 1h;84%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

dichloromethane
75-09-2

dichloromethane

5-diphenylphosphino-17-p-tolyl-25,26,27,28-tetrapropoxycalix[4]arene

5-diphenylphosphino-17-p-tolyl-25,26,27,28-tetrapropoxycalix[4]arene

dichlorido-(η6-cymene)-[5-diphenylphosphino-17-(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene]ruthenium(II)*0.5(dichloromethane)

dichlorido-(η6-cymene)-[5-diphenylphosphino-17-(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene]ruthenium(II)*0.5(dichloromethane)

Conditions
ConditionsYield
In dichloromethane (under N2, Schlenk); soln. of Ru-complex in CH2Cl2 added dropwise to soln. of ligand in CH2Cl2, stirred for 1 h; concd., hexane added; elem. anal.;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

5-diphenylphosphino-11,17,23-tri(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene

5-diphenylphosphino-11,17,23-tri(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene

dichlorido-(η6-cymene)-[5-diphenylphosphino-11,17,23-tris(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene]ruthenium(II)

dichlorido-(η6-cymene)-[5-diphenylphosphino-11,17,23-tris(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene]ruthenium(II)

Conditions
ConditionsYield
In dichloromethane (under N2, Schlenk); soln. of Ru-complex in CH2Cl2 added dropwise to soln. of ligand in CH2Cl2, stirred for 2 h; concd., pentane added; elem. anal.;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

2-{[4-phenyl-1H-1,2,3-triazol-1-yl]methyl}pyridine
1192206-01-1

2-{[4-phenyl-1H-1,2,3-triazol-1-yl]methyl}pyridine

[Ru(η6-p-cymene)Cl(1-(2-picolyl)-4-phenyl-1H-1,2,3-triazole)]Cl
1228235-79-7

[Ru(η6-p-cymene)Cl(1-(2-picolyl)-4-phenyl-1H-1,2,3-triazole)]Cl

Conditions
ConditionsYield
In ethanol mixt. ligand and Ru complex in EtOH was stirred at room temp. for 2 days; hexane was added and left to stand at 4°C for 2 h, soln. was filtered and evapd.;100%
triethylsilane
617-86-7

triethylsilane

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II)
90720-60-8

dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II)

Conditions
ConditionsYield
In benzene-d6 at 20℃; Inert atmosphere; Glovebox;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

4-bromopyridine hydrochloride
19524-06-2

4-bromopyridine hydrochloride

[RuCl2(p-cymene)(4-BrNC5H4)]
1587730-27-5

[RuCl2(p-cymene)(4-BrNC5H4)]

Conditions
ConditionsYield
In dichloromethane at 20℃;100%
In dichloromethane at 20℃;97%
pyridine
110-86-1

pyridine

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

η-p-cymene dichloro(pyridine)ruthenium(II)
52490-96-7

η-p-cymene dichloro(pyridine)ruthenium(II)

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;100%
In dichloromethane at 20℃;89%
In toluene at 20℃; for 4h; Inert atmosphere; Schlenk technique; Reflux;80.2%
In toluene for 3h; Inert atmosphere; Schlenk technique; Reflux;79%
In acetone at 20℃;69%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

4,4'-dinonyl-2,2'-bipyridine
142646-58-0

4,4'-dinonyl-2,2'-bipyridine

dichloro(p-cymene)-4,4′-dinonyl-2,2′-bipyridine ruthenium(II)

dichloro(p-cymene)-4,4′-dinonyl-2,2′-bipyridine ruthenium(II)

Conditions
ConditionsYield
In ethanol for 4h; Reflux;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

bis(1-(pyrimidin-2-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)-1H-imidazol-2(3H)-ylidene)silver(I) dibromoargentate:

bis(1-(pyrimidin-2-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)-1H-imidazol-2(3H)-ylidene)silver(I) dibromoargentate:

(1-(pyrimidin-2-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)-1H-imidazol-2(3H)-ylidene)chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium chloride:

(1-(pyrimidin-2-yl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propyl)-1H-imidazol-2(3H)-ylidene)chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium chloride:

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1h; Inert atmosphere;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

C32H30FeN3O2P

C32H30FeN3O2P

C42H44Cl2FeN3O2PRu

C42H44Cl2FeN3O2PRu

Conditions
ConditionsYield
In dichloromethane for 0.5h; Inert atmosphere; Schlenk technique;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

C28H30FeN3O2P

C28H30FeN3O2P

C38H44Cl2FeN3O2PRu

C38H44Cl2FeN3O2PRu

Conditions
ConditionsYield
In dichloromethane for 0.5h; Inert atmosphere; Schlenk technique;100%
3,5-Lutidine
591-22-0

3,5-Lutidine

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

[Ru(p-cymene)Cl2(3,5-dimethyl pyridine)]

[Ru(p-cymene)Cl2(3,5-dimethyl pyridine)]

Conditions
ConditionsYield
In dichloromethane at 20℃; for 24h;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl
76144-87-1, 76189-55-4, 76189-56-5, 136655-44-2, 98327-87-8

2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl

(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride
130004-33-0, 145926-28-9, 376354-47-1

(2,2'-bis(diphenylphosphino)-1,1'-binaphathalene)chloro(p-cymene)ruthenium chloride

Conditions
ConditionsYield
In ethanol; dichloromethane at 65℃; for 1.5h;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

N-(3R,4R)-3-[(S)-2-(aminomethyl)pyrrolidin-1-yl]-1-benzylpiperidin-4-yl-4-tosylamide

N-(3R,4R)-3-[(S)-2-(aminomethyl)pyrrolidin-1-yl]-1-benzylpiperidin-4-yl-4-tosylamide

C34H48ClN4O2RuS(1+)*Cl(1-)

C34H48ClN4O2RuS(1+)*Cl(1-)

Conditions
ConditionsYield
In isopropyl alcohol at 85℃; for 5h; Schlenk technique; Inert atmosphere;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

N-(3R,4R)-3-[(S)-2-(aminomethyl)pyrrolidin-1-yl]-1-benzylpiperidin-4-yl-4-tosylamide

N-(3R,4R)-3-[(S)-2-(aminomethyl)pyrrolidin-1-yl]-1-benzylpiperidin-4-yl-4-tosylamide

C48H68Cl4N8O4Ru2S2

C48H68Cl4N8O4Ru2S2

Conditions
ConditionsYield
With triethylamine In toluene at 20℃; for 3h; Schlenk technique;100%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

2-amino-5,10-dihydro-5,10-dioxo-4(pyridine-3-yl)-4H-benzo[g]chromene-3-carbonitrile
331859-80-4

2-amino-5,10-dihydro-5,10-dioxo-4(pyridine-3-yl)-4H-benzo[g]chromene-3-carbonitrile

(3‑(2‑amino‑3‑cyano‑5,10‑dihydro‑5,10‑dioxo‑4H‑benzo[g]chromen‑4‑yl)pyridine)(dichlorido)(η5‑p‑cymene)ruthenium(II)

(3‑(2‑amino‑3‑cyano‑5,10‑dihydro‑5,10‑dioxo‑4H‑benzo[g]chromen‑4‑yl)pyridine)(dichlorido)(η5‑p‑cymene)ruthenium(II)

Conditions
ConditionsYield
In acetone at 20℃; for 0.5h;100%
(4-(trifluoromethyl)phenyl)methanethiol
108499-24-7

(4-(trifluoromethyl)phenyl)methanethiol

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

C36H40Cl2F6Ru2S2

C36H40Cl2F6Ru2S2

Conditions
ConditionsYield
at 0℃; for 4h; Inert atmosphere; Schlenk technique;100%
In ethanol Inert atmosphere; Reflux;
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

dichloromethane
75-09-2

dichloromethane

1,1’-((2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene))bis(1H-imidazole)
1012075-54-5

1,1’-((2,3,5,6-tetramethyl-1,4-phenylene)bis(methylene))bis(1H-imidazole)

[Ru(η6-p-cym)(1,4-bis(imidazol-3-ium-1-ylmethyl)-2,3,5,6-tetramethylbenzene)2CH2(Cl)]Cl3*(CH2Cl2)4

[Ru(η6-p-cym)(1,4-bis(imidazol-3-ium-1-ylmethyl)-2,3,5,6-tetramethylbenzene)2CH2(Cl)]Cl3*(CH2Cl2)4

Conditions
ConditionsYield
at 99.84℃; for 24h; Sealed tube;99.8%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

3-(diphenylphosphino)propionic acid
2848-01-3

3-(diphenylphosphino)propionic acid

C25H29Cl2O2PRu

C25H29Cl2O2PRu

Conditions
ConditionsYield
In dichloromethane at 20℃; for 3h; Inert atmosphere; Schlenk technique;99.7%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[Ru(η6-p-cymene)Cl2{P(OMe)3}]
133484-03-4

[Ru(η6-p-cymene)Cl2{P(OMe)3}]

Conditions
ConditionsYield
In hexane under N2, reflux for 4 h; solvent was removed in vac., crystn. at -30 °C from CH2Cl2-petroleum ether overnight, elem. anal.;99.6%
In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;90%
In dichloromethane under N2, Schlenk techniques; soln. of Ru complex in CH2Cl2 stirred at room temp., P(OMe)3 added, mixt. stirred at room temp. for 2 h; soln. concd. under vac., hexanes added, filtered, solid washed with pentane, dried under vac.;76.1%
In dichloromethane Ar or N2-atmosphere; stirring (room temp., 15 min); evapn. (vac.), washing (hexane), filtering, drying (vac.); elem. anal.;63%
In methanol; dichloromethane
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

2-(4-bromophenyl)-1H-imidazo(4,5-f)[1,10]phenanthroline
614717-89-4

2-(4-bromophenyl)-1H-imidazo(4,5-f)[1,10]phenanthroline

C29H25BrClN4Ru(1+)*Cl(1-)

C29H25BrClN4Ru(1+)*Cl(1-)

Conditions
ConditionsYield
at 60℃; for 0.5h; Microwave irradiation;99.3%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

(diphenylphosphino)acetophenone
82363-89-1

(diphenylphosphino)acetophenone

{(η6-p-cymene)Cl2(η1-PPh2CH2COPh)ruthenium(II)}
151267-80-0

{(η6-p-cymene)Cl2(η1-PPh2CH2COPh)ruthenium(II)}

Conditions
ConditionsYield
In chloroform (under Ar or N2, Schlenk techniques); stirred for 1 h; filtd., the filtrate is covered with hexane, elem. anal.;99%
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

dichloromethane
75-09-2

dichloromethane

[((C6H5)3P)2ClRu(μ-Cl)3Ru((CH3)2CO)(P(C6H5)3)2]*(CH3)2CO

[((C6H5)3P)2ClRu(μ-Cl)3Ru((CH3)2CO)(P(C6H5)3)2]*(CH3)2CO

[(cymene)ClRu(μ-Cl)3Ru(P(C6H5)3)2]*0.5CH2Cl2

[(cymene)ClRu(μ-Cl)3Ru(P(C6H5)3)2]*0.5CH2Cl2

Conditions
ConditionsYield
In dichloromethane under dry N2, 2:1 mixt., stirred for 1-2 h; evapd., dried (vac.), elem. anal.;99%

52462-29-0Relevant articles and documents

A new photoactivatable ruthenium(II) complex with an asymmetric bis-thiocarbohydrazone: Chemical and biological investigations

Alinovi, Rossella,Bisceglie, Franco,Orsoni, Nicolò,Pelosi, Giorgio,Pinelli, Silvana,Pioli, Marianna,Scaccaglia, Mirco

, (2021)

The synthesis, photoactivation and biological activity of a new piano-stool Ru(II) complex is herein reported. The peculiarity of this complex is that its monodentate ligand which undergoes the photodissociation is an asymmetric bis-thiocarbohydrazone ligand that possesses a pyridine moiety binding to Ru(II) and the other moiety contains a quinoline that endows the ligand with the capacity of chelating other metal ions. In this way, upon dissociation, the ligand can be released in the form of a metal complex. In this article, the double ability of this new Ru(II) complex to photorelease the ligand and to chelate copper and nickel is explored and confirmed. The biological activity of this compound is studied in cell line A549 revealing that, after irradiation, proliferation inhibition is reached at very low half maximal inhibitory concentration (IC50) values. Further, biological assays reveal that the dinuclear complex containing Ni is internalized in cells.

Design, synthesis and in vitro bioactivity of mixed ligand Ru(II) complexes bearing the fluoroquinolone antibacterial agents

Pulipaka, Ramadevi,Dash, Soumya R.,Khanvilkar, Priyanka,Jana, Sarmita S.,Devkar, Ranjitsinh V.,Chakraborty, Debjani

, p. 721 - 735 (2019)

Mixed ligand Ru(II) phenanthroline complexes of the type [Ru(1,10-phen)2Flq]ClO4 (RPFlq-1-3) and “piano-stool”-type Ru(II) arene complexes [Ru(η6-p-cymene)Cl(Flq)] (RAFlq-1-3), where Flq = fluoroquinolone, have been synthesized, characterized and studied for their anticancer potential. DFT calculations were in line with the proposed structures, wherein the fluoroquinolones are coordinated to the metal through the ring carbonyl and one of the carboxylic oxygen?atoms in a bidentate fashion. Binding efficacies of the synthesized complexes with bovine serum albumin (BSA) and CT-DNA were studied spectroscopically, and it has been established that the arene complexes, though have moderate binding propensities to CT-DNA (Kb = 0.8–1.7 × 103?M?1), have 102–103-fold better binding efficacies toward BSA (Ka = 3.2 × 105–2.1 × 106?M?1) due to the presence of the hydrophobic arene moiety. These results further prompted a study in their in vitro cytotoxicity assay on A-549 non-small cell lung cancer and MCF7 breast cancer cell lines. Furthermore, gene expression studies on BAX and BCL-2 genes and FACS analysis confirmed apoptosis as the mode of cell death.

Evaluation of biomolecular interactions and cytotoxic activity of organometallic binuclear Ru(II) complexes of ferrocenyl thiosemicarbazones

Khanvilkar, Priyanka,Dash, Soumya R.,Vohra, Alisagar,Devkar, Ranjitsinh,Chakraborty, Debjani

, p. 6044 - 6055 (2021)

Four new ferrocenyl substituted thiosemicarbazone ligands (L1–L4) and their corresponding binuclear ruthenium(II) arene complexes of the general type [(η6-p cym)(L)Ru(μ-im)Ru(L)(η6-p-cym)]Cl (C1–C4) and [(η6-p cym)(L)Ru(μ-azpy)Ru(L)(η6-p-cym)]Cl2 (C5–C8) (cym = cymene, im = imidazole, azpy = 4,4′-azopyridine) have been synthesized and characterized. The structures of the complexes were established through DFT calculations and geometry optimization. The interactions of the binuclear complexes with DNA were investigated by absorption, emission and viscosity studies which indicated that the complexes bind to DNA via intercalation. Meanwhile, the interaction of complexes with the protein, bovine serum albumin (BSA), has also been studied using fluorescence emission spectroscopy. The experimental results show that the binuclear complexes exhibit good binding propensities to BSA. The complexes can quench the intrinsic fluorescence of BSA remarkably through a static or dynamic quenching process. In addition, the in?vitro cytotoxicity of complexes C1–C8 against HeLa cell line was assayed which showed lower IC50 values indicating their higher cytotoxicity and potency in killing the cancer cells at low concentrations. Communicated by Ramaswamy H. Sarma.

Mixed ligand ruthenium arene complexes containing N-ferrocenyl amino acids: Biomolecular interactions and cytotoxicity against MCF7 cell line

Ramadevi, Pulipaka,Singh, Rinky,Jana, Sarmita S.,Devkar, Ranjitsinh,Chakraborty, Debjani

, p. 80 - 87 (2017)

Synthesis, characterization, DNA and protein binding as well as anticancer activity of the organometallic complexes [Ru(η6-p-cym)(L)Cl] (where, p-cym?=?p-cymene MeC6H4Pri, L?=?N-ferrocenyl amino acid conjugates) RAFcA 1–4 have been described. The complexes 1–4 exhibited strong DNA/BSA binding and anticancer activity against breast cancer MCF7 cell line. Their binding with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) have been examined by absorption and emission spectral studies. Strong interactions between complexes and CT-DNA have been affirmed by absorption spectral and EB displacement studies, while interaction with BSA via static quenching was explored by fluorescence titration. Cytotoxicity, apoptosis and in?vitro anticancer activity of 1–4 toward MCF7 cell line have been investigated by MTT assay. The IC50values (37.1?μM - 86.6?μM) were found to be distinctly lower than those of NAMI-A and RAPTA complexes for MCF7 cell line which was followed by gene expression studies to confirm apoptosis as the mode of cell death.

Anticancer activity of hydrogen-bond-stabilized half-sandwich Ru II complexes with heterocycles

Mitra, Raja,Das, Sangeeta,Shinde, Sridevi V.,Sinha, Sarika,Somasundaram, Kumaravel,Samuelson, Ashoka G.

, p. 12278 - 12291 (2012)

Neutral half-sandwich organometallic ruthenium(II) complexes of the type [(n6-cymene)RuCl2(L)] (H1-H10), where L represents a heterocyclic ligand, have been synthesized and characterized spectroscopically. The structures of five complexes were also established by single-crystal X-ray diffraction confirming a piano-stool geometry with n6 coordination of the arene ligand. Hydrogen bonding between the N-H group of the heterocycle and a chlorine atom attached to Ru stabilizes the metal-ligand interaction. Complexes coordinated to a mercaptobenzothiazole framework (H1) or mercaptobenzoxazole (H6) showed high cytotoxicity against several cancer cells but not against normal cells. In vitro studies have shown that the inhibition of cancer cell growth involves primarily G1-phase arrest as well as the generation of reactive oxygen species (ROS). The complexes are found to bind DNA in a non-intercalative fashion and cause unwinding of plasmid DNA in a cell-free medium. Surprisingly, the cytotoxic complexes H1 and H6 differ in their interaction with DNA, as observed by biophysical studies, they either cause a biphasic melting of the DNA or the inhibition of topoisomerase-IIα activity, respectively. Substitution of the aromatic ring of the heterocycle or adding a second hydrogen-bond donor on the heterocycle reduces the cytotoxicity. Copyright

The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand

Huxham, Lynsey A.,Cheu, Elizabeth L.S.,Patrick, Brian O.,James, Brian R.

, p. 238 - 246 (2003)

Two diruthenium(II) complexes [RuCl2(p-cymene)]2(μ-BESE) (1), [RuCl2(p-cymene)]2(μ-BESP) (2), and the mononuclear salt [RuCl(p-cymene)(BESE)]PF6 (3), containing the disulfoxides BESE and BESP, were synthesized and characterized by elemental analysis, and NMR and IR spectroscopies, and were shown to contain S-bound sulfoxide groups; the disulfoxides are EtS(O)(CH2)nS(O)Et, where n=2 (BESE) or 3 (BESP). Complexes 1 and 3 were also characterized by X-ray crystallography. Preliminary in vitro tests of 1 and 3 were conducted using the MTT assay, which measures mitochondrial dehydrogenase activity as an indication of cell viability; these complexes showed in vitro anti-cancer activity against a human mammary cancer cell line (MDA-MB-435s) with IC50 values of 360 and 55 μM, respectively.

Selective Targeting of the Zinc Finger Domain of HIV Nucleocapsid Protein NCp7 with Ruthenium Complexes

Sheng, Yaping,Cao, Kaiming,Li, Ji,Hou, Zhuanghao,Yuan, Siming,Huang, Guangming,Liu, Hongke,Liu, Yangzhong

, p. 19146 - 19151 (2018)

Nucleocapsid protein 7 (NCp7) is an attractive target for anti-HIV drug development. Here we found that ruthenium complexes are reactive to NCp7 and various Ru-agents exhibit significantly different reactivity. Interestingly, the zinc-finger domains of NCp7 also demonstrate different affinity to Ru-complexes; the C-terminal domain is much more reactive than the N-terminal domain. Each zinc-finger domain of NCp7 binds up to three Ru-motifs, and the ruthenium binding causes zinc-ejection from NCp7 and disrupts the protein folding. Therefore, ruthenium complexes interfere with the DNA binding of NCp7 and interrupt the protein function. The different reactivity of Ru-agents suggests a feasible strategy for improving the targeting of NCp7 by ligand design. This work provides an insight into the mechanism of ruthenium complex with NCp7, and suggests more potential application of ruthenium drugs.

Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against: Leishmania amazonensis

Colina-Vegas, Legna,Lima Prado Godinho, Joseane,Coutinho, Thallita,Correa, Rodrigo S.,De Souza, Wanderley,Cola Fernandes Rodrigues, Juliany,Batista, Alzir Azevedo,Navarro, Maribel

, p. 1431 - 1439 (2019)

Four new organoruthenium complexes with formula [RuCl(η6-p-cymene)(μ-FCZ)]2[Cl]2 (1), [RuCl(FCZ)(η6-p-cymene)(PPh3)]PF6 (2), [RuCl(CTZ)(η6-p-cymene)(PPh3)]PF6 (3) and [RuCl(KTZ)(η6-p-cymene)(PPh3)]PF6 (4) (where FCZ: 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)-2-propanol, CTZ: 1-[(2-chlorophenyl)-diphenylmethyl-1H-imidazole] and KTZ: cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine) were synthesized, characterized and evaluated as potential inhibitors for Leishmania amazonensis growth by widely reported methods. Complexes 3 and 4 displayed effective IC50 activities against Leishmania amazonensis promastigotes and intracellular amastigotes in the range of nanomolar concentration. Scanning and transmission electron microscopy analysis of Leishmania amazonensis promastigotes after treatment with 300 or 500 nM of complexes 3 and 4 for 48 h showed morphological alterations in the cell surface, a shortening of the flagellum, loss of mitochondrial matrix, disorganization of the kDNA and abnormal chromatin condensation. Thus, our strategy of incorporating a ruthenium atom into the structure of clinical drugs to improve their efficacy continues to demonstrate suitability for metallodrug discovery purposes.

Cationic half-sandwich ruthenium (II) complexes ligated by pyridyl-triazole ligands: Transfer hydrogenation and mechanistic studies

Joseph, M. C.,Mapolie, S. F.,Swarts, A. J.

supporting information, (2021/11/30)

A series of novel cationic ruthenium half-sandwich complexes, bearing 1-substituted-4-pyridyl-1H-1,2,3-triazole ligands, were synthesized and fully characterized by a range of analytical techniques. The complexes were found to be efficient catalyst precursors for transfer hydrogenation reactions using ketones as substrates. We demonstrated that the complexes could hydrogenate acetophenone in excellent conversions (~75 %) within 3 h, employing a low concentration of base of only 2 mol %. Extending the reaction time to 6 h gave near quantitative conversions for both catalysts employed. In addition to this, the transfer hydrogenation of acetophenone was also found to proceed even at low catalyst loadings (0.025–0.05 mol%) and low base concentrations (0.25–1.0 mol%). Under these conditions substrate conversion was moderate (22–60 %). The catalytic efficiency of the most effective catalyst was then evaluated in the transfer hydrogenation of a small library of aromatic and aliphatic ketones. It was shown that more challenging substrates such as benzophenone and 2-octanone could be hydrogenated to the corresponding secondary alcohols in conversions > 90 %. Finally, based on several experimental observations, a possible mechanism for the process is proposed.

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