5773-56-8

Basic information

• Product Name: (S)-(+)-1,2-DIPHENYLETHANOL
• Synonyms: (S)-(+)-1,2-DIPHENYLETHANOL;(S)-1,2-DIPHENYL-ETHANOL;(S)-(+)-1,2-DIPHENYLETHANOL, 95% (98% E.E.);(S)-(+)-1,2-Diphenylethanol, (98% E.E.)
• CAS NO: 5773-56-8
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26
• Mol File: 5773-56-8.mol
• Article Data: 202

Chemical Properties

• Melting Point: 67.5°C
• Boiling Point: 295.58°C (rough estimate)
• Flash Point: 129.4°C
• Appearance: /
• Density: 1.0358
• Vapor Pressure: 0.000301mmHg at 25°C
• Refractive Index: 1.5680 (estimate)
• CAS DataBase Reference: (S)-(+)-1,2-DIPHENYLETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1,2-DIPHENYLETHANOL(5773-56-8)
• EPA Substance Registry System: (S)-(+)-1,2-DIPHENYLETHANOL(5773-56-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 5773-56-8(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder and chunks

InChI:InChI=1/C14H14O/c15-14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-10,14-15H,11H2/t14-/m0/s1

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 141-52-6 sodium ethanolate 
• 96-09-3 styrene oxide 
• 60-29-7 diethyl ether 
• 591-51-5 phenyllithium 
• 19179-21-6 (+/-)-2r-methoxy-2,3c-diphenyl-oxirane 
• 7471-49-0 1,2,3,4-tetraphenyl-2,3-butanediol 
• 103-50-4 dibenzyl ether 
• 572-45-2 benzil dioxime 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 100-52-7 benzaldehyde 
• 1589-82-8 phenylmagnesium bromide 
• 1121-53-5 benzyl sodium 
• 1689-71-0 2,3-diphenyloxirane 

Downstream Products

• 18044-11-6 β-phenyl-α-(trimethylsiloxy)ethylbenzene 
• 451-40-1 phenyl benzyl ketone 
• 4023-77-2 1-benzoyl-1,2-diphenylethylene 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 4714-14-1 Chloro-1 diphenyl-1,2 ethane 
• 3321-50-4 1,2-dicyclohexylethane 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 24295-35-0 1-acetoxy-1,2-diphenylethane 
• 38321-68-5 Thiobenzoesaeure-O-1,2-diphenylaethylester 
• 794-06-9 α-(N-morpholino)-α-phenylacetophenone 
• 38793-43-0 bis-bibenzyl-α-yl ether 
• 100-52-7 benzaldehyde 
• 65-85-0 benzoic acid 
• 62677-53-6 trans,trans-1,2,3-triphenyl-2,3-dihydro-1H-indene 

Relevant articles and documents

Standardization and Control of Grignard Reactions in a Universal Chemical Synthesis Machine using online NMR

A big problem with the chemistry literature is that it is not standardized with respect to precise operational parameters, and real time corrections are hard to make without expert knowledge. This lack of context means difficult reproducibility because many steps are ambiguous, and hence depend on tacit knowledge. Here we present the integration of online NMR into an automated chemical synthesis machine (CSM aka. “Chemputer” which is capable of small-molecule synthesis using a universal programming language) to allow automated analysis and adjustment of reactions on the fly. The system was validated and benchmarked by using Grignard reactions which were chosen due to their importance in synthesis. The system was monitored in real time using online-NMR, and spectra were measured continuously during the reactions. This shows that the synthesis being done in the Chemputer can be dynamically controlled in response to feedback optimizing the reaction conditions according to the user requirements.

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.