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Cas Database

61-19-8

61-19-8

Identification

  • Product Name:Adenosine 5'-monophosphate

  • CAS Number: 61-19-8

  • EINECS:200-500-0

  • Molecular Weight:347.224

  • Molecular Formula: C10H14N5O7P

  • HS Code:HOSPHATE PRODUCT IDENTIFICATION

  • Mol File:61-19-8.mol

Synonyms:5'-AMP;AMP (nucleotide);Adenosine 5'-(dihydrogen phosphate);Adenosine 5'-phosphate;Adenosine 5'-phosphoric acid;Adenosine monophosphate;Adenosine phosphate;Adenosine-5-monophosphoric acid;Adenovite;Adenylic acid;Cardiomone;Lycedan;My-B-Den;NSC 20264;Phosaden;Phosphaden;Phosphentaside;5'-Adenylic acid;

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Safety information and MSDS view more

  • Signal Word:No signal word.

  • Hazard Statement:none

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Absorption, Distribution and ExcretionAMP ADMIN TO RATS ORALLY WAS RECOVERED INTACT IN BLOOD. IT APPEARED RAPIDLY IN BLOOD (IN 15-30 MIN) & WAS ALSO RAPIDLY DISTRIBUTED, SINCE PLASMA CONCN WAS DECR BY FACTOR OF 5 IN 2 HR.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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  • Manufacture/Brand:TRC
  • Product Description:Adenosine5''-Monophosphate
  • Packaging:100g
  • Price:$ 250
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  • Product Description:Adenosine5''-Monophosphate
  • Packaging:5g
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  • Product Description:Adenosine5''-Monophosphate
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  • Manufacture/Brand:TCI Chemical
  • Product Description:5'-Adenylic Acid >98.0%(HPLC)(T)
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Relevant articles and documentsAll total 137 Articles be found

Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System

Bechtel, Maximilian,Closs, Anna C.,Trapp, Oliver

supporting information, (2021/12/01)

All evolutionary biological processes lead to a change in heritable traits over successive generations. The responsible genetic information encoded in DNA is altered, selected, and inherited by mutation of the base sequence. While this is well known at the biological level, an evolutionary change at the molecular level of small organic molecules is unknown but represents an important prerequisite for the emergence of life. Here, we present a class of prebiotic imidazolidine-4-thione organocatalysts able to dynamically change their constitution and potentially capable to form an evolutionary system. These catalysts functionalize their building blocks and dynamically adapt to their (self-modified) environment by mutation of their own structure. Depending on the surrounding conditions, they show pronounced and opposing selectivity in their formation. Remarkably, the preferentially formed species can be associated with different catalytic properties, which enable multiple pathways for the transition from abiotic matter to functional biomolecules.

Reduced nicotinamide mononucleotide is a new and potent nad+ precursor in mammalian cells and mice

Zapata-Pérez, Rubén,Tammaro, Alessandra,Schomakers, Bauke V.,Scantlebery, Angelique M. L.,Denis, Simone,Elfrink, Hyung L.,Giroud-Gerbetant, Judith,Cantó, Carles,López-Leonardo, Carmen,McIntyre, Rebecca L.,van Weeghel, Michel,Sánchez-Ferrer, álvaro,Houtkooper, Riekelt H.

, p. 1 - 17 (2021/03/22)

Nicotinamide adenine dinucleotide (NAD+) homeostasis is constantly compromised due to degradation by NAD+-dependent enzymes. NAD+ replenishment by sup-plementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can alleviate this imbalance. However, NMN and NR are limited by their mild effect on the cellular NAD+ pool and the need of high doses. Here, we report a synthesis method of a reduced form of NMN (NMNH), and identify this molecule as a new NAD+ precursor for the first time. We show that NMNH increases NAD+ levels to a much higher extent and faster than NMN or NR, and that it is metabolized through a different, NRK and NAMPT-independent, pathway. We also demonstrate that NMNH reduces damage and accelerates repair in renal tubular epithelial cells upon hypoxia/reoxygenation injury. Finally, we find that NMNH administration in mice causes a rapid and sustained NAD+ surge in whole blood, which is accompanied by increased NAD+ levels in liver, kidney, muscle, brain, brown adipose tissue, and heart, but not in white adipose tissue. Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.

Intrinsic Apyrase-Like Activity of Cerium-Based Metal–Organic Frameworks (MOFs): Dephosphorylation of Adenosine Tri- and Diphosphate

Gu, Jinlou,Li, Chunzhong,Li, Ke,Yang, Jian

supporting information, p. 22952 - 22956 (2020/10/23)

Apyrase is an important family of extracellular enzymes that catalyse the hydrolysis of high-energy phosphate bonds (HEPBs) in ATP and ADP, thereby modulating many physiological processes and driving life activities. Herein, we report an unexpected discovery that cerium-based metal–organic frameworks (Ce-MOFs) of UiO-66(Ce) have intrinsic apyrase-like activity for ATP/ADP-related physiological processes. The abundant CeIII/CeIV couple sites of Ce-MOFs endow them with the ability to selectively catalyse the hydrolysis of HEPBs of ATP and ADP under physiological conditions. Compared to natural enzymes, they could resist extreme pH and temperature, and present a broad range of working conditions. Based on this finding, a significant inhibitory effect on ADP-induced platelet aggregation was observed upon exposing the platelet-rich plasma (PRP) to the biomimetic UiO-66(Ce) films, prefiguring their wide application potentials in medicine and biotechnology.

Process route upstream and downstream products

Process route

C<sub>49</sub>H<sub>62</sub>N<sub>20</sub>O<sub>31</sub>P<sub>4</sub>

C49H62N20O31P4

cytidine monophosphate
63-37-6,30811-80-4

cytidine monophosphate

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Guanosine 5'-monophosphate
85-32-5

Guanosine 5'-monophosphate

Conditions
Conditions Yield
venom phosphodiesterase; Product distribution;
C<sub>51</sub>H<sub>67</sub>N<sub>21</sub>O<sub>34</sub>P<sub>5</sub><sup>(1-)</sup>

C51H67N21O34P5(1-)

[5']adenylic acid mono-(2-amino-ethyl) ester
6216-59-7

[5']adenylic acid mono-(2-amino-ethyl) ester

cytidine monophosphate
63-37-6,30811-80-4

cytidine monophosphate

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Guanosine 5'-monophosphate
85-32-5

Guanosine 5'-monophosphate

Conditions
Conditions Yield
nuclease P1; Product distribution;
adenosine-5'-phosphoric hexadecanoic anhydride
14170-04-8

adenosine-5'-phosphoric hexadecanoic anhydride

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

Conditions
Conditions Yield
With 3-{[tris(hydroxymethyl)methyl]amino}propanesulfonic acid; water; In pyridine; dimethylsulfoxide-d6; at 37 ℃; Rate constant; hydrolysis;
adenosine-5'-monophosphate disodium salt
4578-31-8

adenosine-5'-monophosphate disodium salt

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
With Dowex 50W×8 resin; In water; at 20 ℃; for 0.5h;
99%
With Dowex 50WX-8 200 mesh, H+;
C<sub>17</sub>H<sub>22</sub>N<sub>6</sub>O<sub>12</sub>P<sub>2</sub>S

C17H22N6O12P2S

4-Methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid

4-Methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
With magnesium chloride; snake venom nucleotide pyrophosphatase; In water; at 37 ℃; for 2h;
With nucleotide pyrophosphatase; pH=7.2; Enzymatic reaction;
cAMP
60-92-4

cAMP

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
With magnesium(II); In water; at 38 ℃; pH=7.0; Equilibrium constant; Thermodynamic data;
With hydrogenchloride; ethylenediaminetetraacetic acid; maltose binding protein-fused human cyclic nucleotide phosphodiesterase 4B2; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride; In water; pH=7.4; Kinetics; Enzymatic reaction;
With recombinant human phosphodiesterase type 1; 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[3-(2,6-dimethylmorpholin-4-yl)-2-hydroxypropyl]oxime; tris hydrochloride; In dimethyl sulfoxide; at 30 ℃; for 0.333333h; pH=7.4; Reagent/catalyst; Kinetics;
With bovine serum albumin; In aq. buffer; at 30 ℃; Enzymatic reaction;
With ethylenediaminetetraacetic acid; recombinant N-terminally GST-tagged human cardiac phosphodiesterase PDE3A (484–1141); magnesium chloride; BSA; In aq. buffer; at 30 ℃; for 0.0333333h; pH=7.5; Concentration; Kinetics; Catalytic behavior; Enzymatic reaction;
With rhodopsin fused to a C-terminal cyclic nucleotide phosphodiesterase domain; sodium chloride; sodium hydroxide; magnesium chloride; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In aq. buffer; at 20 ℃; pH=6.5; Irradiation; Enzymatic reaction;
Conditions
Conditions Yield
With barium dihydroxide;
With pyridine;
Hydrolysis.mit Hilfe eines Enzym-Extrakts aus Kaninchen-Leber;
With pyrophosphatase; Hydrolysis.Pyrophosphatase aus Kartoffeln;
With sodium perchlorate; zinc(II) cation; at 50 ℃; Rate constant; var. pH's;
With 2-{[4-(3-aminopropylamino)butylcarbamoyl]methyl}-2-hydroxysuccinic acid; pyruvate kinase; N-(3-aminopropyl)-1,4-diaminobutane; phosphoenolpyruvic acid; His(6)-AsbB synthetase; myokinase; NADH; magnesium chloride; lactate dehydrogenase; In tris hydrochloride; at 37 ℃; for 0.333333h; pH=8.0; Reagent/catalyst; Concentration; Kinetics; Enzymatic reaction;
With potato apyrase; for 2h; Enzymatic reaction;
With 5-O-sulfamoyl-N6-[(1S)-2,3-dihydro-1H-inden-1-yl]adenosine; human N-terminus His6-tagged ubiquitin-activating enzyme 1; human ubiquitin-conjugating enzyme UbcH10; magnesium chloride; bovine ubiquitin; at 37 ℃; pH=7.5; Concentration; Kinetics; aq. HEPES buffer; Enzymatic reaction;
With aqueous cadmium chloride; L-glutamic acid; at 80 ℃; pH=7; Kinetics; Inert atmosphere;
With sodium azide; profilin; ethylene glycol-bis(2-aminoethyl)-N,N,N'N,'-tetraacetic acid; inverted formin2, CAAX variant; rabbit skeletal muscle actin; potassium chloride; Imidazole hydrochloride; magnesium chloride; diothiothreitol; In aq. buffer; at 23 ℃; for 19h; pH=7.4; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;
With pyruvate kinase; myokinase; Escherichia coli acetyl-CoA synthetase; coenzyme A; NADH; magnesium chloride; Cleland's reagent; lactate dehydrogenase; In aq. phosphate buffer; at 37 ℃; pH=7.5; Reagent/catalyst; Kinetics; Enzymatic reaction;
With apyrase; In dimethyl sulfoxide; pH=7.4; Enzymatic reaction;
With cis-Octadecenoic acid; long-chain acyl-coenzyme A synthetase 1 from mouse; magnesium sulfate; coenzyme A; sodium chloride; In aq. buffer; Kinetics; Enzymatic reaction;
adenosine 5'-diphosphate
58-64-0,905904-58-7

adenosine 5'-diphosphate

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
With water; at 70 ℃; Rate constant; Kinetics; Thermodynamic data; effect of pH (3.20-10.06); temperature 60-70-80 deg C; ionic strength: 0.5; ΔH(excit.), ΔS(excit.), ΔG(excit.);
With macrocyclic polyamine; In water; water-d2; at 60 ℃; Rate constant; hydrolysis; without reagents; with other macrocyclic polyamines;
With mouse nucleoside triphosphate diphosphohydrolase-3; 2-amino-2-hydroxymethyl-1,3-propanediol; calcium chloride; In various solvent(s); pH=7.4; Enzyme kinetics;
With nucleoside triphosphate diphosphohydrolase from Legionella pneumophila; In aq. buffer; at 37 - 99 ℃; for 0.25h; Kinetics; Enzymatic reaction;
With SmNPP5; Enzymatic reaction;
adenosine
58-61-7

adenosine

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
adenosine; With trichlorophosphate; at 20 ℃; for 0.1h; Flow reactor; Green chemistry;
With water; at 20 ℃; Temperature; chemoselective reaction; Flow reactor; Green chemistry;
86%
With tris(p-nitrophenyl)phosphate; at 50 ℃; Erwina herbicola 47/3 cells;
65%
With trichlorophosphate; In water; for 0.5h; Solvent;
27%
With brewer's yeast; inorganic phosphate;
With triethyl phosphate; trichlorophosphate; In water; at 0 ℃; for 2h; Rate constant; Product distribution; var. reaction conditions;
90 % Chromat.
Multistep reaction;
With Chinese hamster ovary cell-derived adenosine kinase; ATP; magnesium chloride; In phosphate buffer; at 37 ℃; pH=7.3; Enzyme kinetics;
Multi-step reaction with 4 steps
1: pyridine
2: pyridine
3: aqueous acetic acid
4: ueber mehrere Stufen
With pyridine; acetic acid;
With phosphoenolpyruvic acid; ATP; at 25 ℃; pH=5.8; Enzyme kinetics;
With [γ-33P]adenosine triphosphate; human adenosine kinase; ATP; magnesium chloride; at 23 ℃; for 1h; pH=7.5; aq. buffer; Enzymatic reaction;
Multi-step reaction with 3 steps
1: unter Zusatz von ZnCl2
2: pyridine; trichlorophosphate / und ansclissend mit wss.Pyridin
3: sulfuric acid
With pyridine; sulfuric acid; trichlorophosphate;
With brewer's yeast; inorganic phosphate;
1H-benzotriazole adenine dinucleotide ammonium salt

1H-benzotriazole adenine dinucleotide ammonium salt

1H-benzotriazole mononucleotide ammonium salt
123499-58-1

1H-benzotriazole mononucleotide ammonium salt

5'-adenosine monophosphate
61-19-8,24937-83-5,67583-85-1

5'-adenosine monophosphate

Conditions
Conditions Yield
With phosphodiesterase; tris hydrochloride; magnesium chloride; In water; at 37 ℃; for 12h; pH: 9.0;
0.31 g
96%

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