614-22-2

Basic information

• Product Name: BENZOYLUREA
• Synonyms: BENZOYLUREA;BENZOYLCARBAMIDE;LABOTEST-BB LT00454341;1-benzoylurea;benzoyl-ure;n-(aminocarbonyl)-benzamid;n-benzoylurea;Benzoylurea,97%
• CAS NO: 614-22-2
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16
• EINECS: 210-372-8
• Mol File: 614-22-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 209-210°C
• Appearance: /
• Density: 1.257g/cm3
• Refractive Index: 1.579
• PKA: 10.79±0.46(Predicted)
• BRN: 2045538
• CAS DataBase Reference: BENZOYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOYLUREA(614-22-2)
• EPA Substance Registry System: BENZOYLUREA(614-22-2)

Safety Data

• Safety Statements: 22-24/25
• RTECS: YR9070000
• Hazardous Substances Data: 614-22-2(Hazardous Substances Data)

Usage

Description

Benzoylureas have some of the most unusual physical properties of any crop protection chemicals. They are all highly crystalline, lipophilic solids with high melting points. Consequently, they have extremely low vapor pressure, very low water-solubility, and their solubility in many organic solvents is also low.

Definition

ChEBI: An N-acylurea that is urea in which one of the hydrogens is replaced by a benzoyl group.

InChI:InChI=1/C8H8N2O2/c9-8(12)10-7(11)6-4-2-1-3-5-6/h1-5H,(H3,9,10,11,12)

Upstream product

• 7664-41-7 ammonia 
• 4461-33-0 benzoyl isocyanate 
• 7647-01-0 hydrogenchloride 
• 58476-79-2 N-(iminomethoxymethyl)benzamide 
• 4971-80-6 ethyl N-benzoylcarbamate 
• 93-58-3 benzoic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 2414-98-4 magnesium ethylate 
• 55-21-0 benzamide 
• 76-02-8 trifluoroacetyl chloride 
• 94123-66-7 S-phenyl 2-oxo-2-phenylethanethioate 
• 110-89-4 piperidine 
• 67-56-1 methanol 
• 538-32-9 benzylurea 

Downstream Products

• 39970-19-9 N-(cyclohexylcarbamoyl)benzamide 
• 1421634-93-6 [UO(O₂)N-benzoylurea(NO₃)₂] monohydrate 
• 84043-71-0 5-Phenoxymethyl-2-phenyl-[1,3,4]oxadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 84043-65-2 2,5-Diphenyl-[1,3,4]oxadiazolo[3,2-a][1,3,5]triazine-7-thione 
• 1483-31-4 2-chloro-5-phenyl-1,3,4-oxadiazole 
• 40288-05-9 2-phenyl-[1,3,4]oxadiazolo[2,3-b]quinazolin-5-one 
• 613-94-5 benzoic acid hydrazide 
• 29376-05-4 N-benzoyl-N'-chloro-urea 
• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 113260-70-1 N-(o-tolylcarbamoyl)benzamide 
• 142267-51-4 N-((2-chlorophenyl)carbamoyl)benzamide 
• 1821-33-6 N-phenyl-N'-benzoylurea 
• 121001-30-7 N³-benzoylquinazoline-2,4-dione 
• 57160-46-0 N-((4-chlorophenyl)carbamoyl)benzamide 

Relevant articles and documents

N,O-Benzyl Protection of Structurally Varied Amines and Phenols Using Wells-Dawson Heteropolyacid Catalyst

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Gentle method for carbonylation and arylation reaction of urea compounds

The invention discloses a gentle method for carbonylation and arylation reaction of urea compounds. The method includes a step of performing a coupling carbonylation reaction to a halogenated aromatic compound with a urea compound under a gentle condition to produce a ureide compound, palladium acetate being a catalyst, triethylamine being an alkali, and pentacarbonyl iron being a CO release source. The method has simple operations and gentle reaction condition, is low in usage amount of the catalyst and the CO release source, is low in toxicity and cost, has wide substrate applicability and high yield of the target product, and can be widely applied to preparation of a ureide compound medicine molecule.

Solid-phase synthesis of disubstituted N -acylureas from resin-bound ureas and acyl chlorides

Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N′-alkylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.