6147-53-1

Basic information

• Product Name: Cobalt(II) acetate tetrahydrate
• Synonyms: Aceticacid,cobalt(2+)salt,tetrahydrate;bis(acetato)tetraquacobalt;Bis(acetato)tetraquocobalt;cobaltdiacetatetetrahydrate;octankobaltnaty;Cobaltous acetate Bis(acetato)tetraquocobalt;COBALT ACETAT;Cobalt(II) acetate tetrahydrate, 99.999% metals basis
• CAS NO: 6147-53-1
• Molecular Formula: 2C₂H₃O₂*Co*4H₂O
• Molecular Weight: 249.08
• EINECS: 200-755-8
• Product Categories: Inorganic Chemicals;metal acetate salt;cobalt , acetate
• Mol File: 6147-53-1.mol

Chemical Properties

• Melting Point: 140 °C
• Boiling Point: 117.1 °C at 760 mmHg
• Flash Point: 40 °C
• Appearance: Red/Solid
• Density: 1,71 g/cm3
• Refractive Index: 1.542
• Storage Temp.: Store at R.T.
• Solubility: 348g/l
• Water Solubility: 380 g/L (20 ºC)
• Sensitive: Hygroscopic
• Stability: Stable. Avoid moisture, heat.
• Merck: 14,2433
• BRN: 3731397
• CAS DataBase Reference: Cobalt(II) acetate tetrahydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Cobalt(II) acetate tetrahydrate(6147-53-1)
• EPA Substance Registry System: Cobalt(II) acetate tetrahydrate(6147-53-1)

Safety Data

• Hazard Codes: Xn,N,T
• Statements: 22-38-40-43-53-50/53-42/43-36/37/38-20/21/22-68-60-49
• Safety Statements: 36/37-61-45-29-24-22-37/39-36/37/39-26-60-53
• RIDADR: 3077
• WGK Germany: 2
• RTECS: AG3325000
• TSCA: No
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 6147-53-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Cobalt(II) acetate tetrahydrate is used as a precursor in the synthesis of various cobalt-containing compounds, such as cobalt nanoparticles, cobalt(II)–aminophenyltetrazolate coordination polymer, and tricobalt complexes with mixed μ-acetato and μ-pyrazolato ligands.
Used in Coordination Chemistry:
It is utilized to prepare metal complexes with unusual coordination geometries, which are essential for examining the properties of metals in different environments.
Used in Catalyst Applications:
Cobalt(II) acetate tetrahydrate serves as a catalyst in oxidation and esterification reactions, playing a crucial role in various chemical processes.
Used in Industrial Applications:
In the paint and varnish industry, Cobalt(II) acetate tetrahydrate is used as an active catalyst to harden these materials, improving their durability and performance.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen. A skin and eye irritant. Human mutation data reported. See also COBUT COMPOUNDS. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Several recrystallisations from 50% aqueous acetic acid give the tetrahydrate. It is converted to the anhydrous salt by drying at 80o/1mm for 60hours. [Beilstein 2 IV 120.]

InChI:InChI=1/C2H4O2.Co.4H2O/c1-2(3)4;;;;;/h1H3,(H,3,4);;4*1H2/q;+2;;;;/p-1

Synthetic route

Co(galvinoxyl)2 + water (7732-18-5) + acetic acid (64-19-7) → cobalt(II) diacetate tetrahydrate (6147-53-1)

Conditions	Yield
In pentane byproducts: hydroxygalvinol; aq. acetic acid (0.52 mmol) and n-pentane were added to Co-contg. compd.(0.20 mmol) at room temp.; standing overnight; sepn. of the phases and removing of the solvent in vac.;	84%

cobalt(III) hydroxide + cobalt (7440-48-4) + acetic acid (64-19-7) → cobalt(II) diacetate tetrahydrate (6147-53-1)

Conditions	Yield
In acetic acid 2.5-3.25 atm; 120°C; autoclave;; crystn. on cooling;;
In acetic acid aq. acetic acid; 2.5-3.25 atm; 120°C; autoclave;; crystn. on cooling;;
In acetic acid 2.5-3.25 atm; 120°C; autoclave;; crystn. on cooling;;

acetic acid (64-19-7) + cobalt(II) carbonate (759403-02-6) → cobalt(II) diacetate tetrahydrate (6147-53-1)

Conditions	Yield
In not given byproducts: CO2, H2O; elem. anal.;
In acetic acid aq. acetic acid; soln. of CoCO3 in aq. acetic acid; crystn.;;

cobalt (7440-48-4) + acetic acid (64-19-7) → cobalt(II) diacetate tetrahydrate (6147-53-1)

Conditions	Yield
In acetic acid Electrolysis; electrolysis (Cr18Ni10Ti cathode, 35+/-2°C, 12.5 A/dm**2, 10 h, 31-45, 17-35, 33-38 or 37-48 V poten. drop across cell or 35-40 V poten.drop across cell, 1.2, 9.2, 12,5, 8.3 or 0.95 A/dm**2); continous crystn.;
In not given Electrochem. Process;

cobalt(III) nitrate + ethanol (64-17-5) → cobalt(II) diacetate tetrahydrate (6147-53-1)

Conditions	Yield
With urea at 90℃; for 10h; Autoclave;

5,10,15,20-tetrakis(pentafluorophenyl)porphyrin + cobalt(II) diacetate tetrahydrate (6147-53-1) → C52H32CoF16N8 (129707-78-4)

Conditions	Yield
In N,N-dimethyl-formamide refluxed for 12 h; dried, chromy. (neutral alumina) with benzene and CH2Cl2 as eluting solvent, recrystn. (CH2Cl2/benzene 1:9); elem. anal.;	100%

N,N'-bis(salicylidene)-o-phenylenediamine (3946-91-6) + cobalt(II) diacetate tetrahydrate (6147-53-1) → N,N'-bis(salicylidene)-1,2-phenylene diaminocobalt(II) (17457-14-6, 39836-45-8)

Conditions	Yield
In propan-1-ol under N2; suspn. of Co compd. warmed to 50 °C; org. compd. addedin one portion; suspn. refluxed for 6 h; mixt. cooled, filtered under reduced pressure; collected solid washed with Et2O and dried in air to give crystals;	100%
With acetic acid In ethanol; dichloromethane at 60℃; for 2h;	85.3%
In methanol reflux of a mixture of ligand and Co-acetate in CH3OH for 1 h, cooling; filtration, washing with CH3OH and ether, drying under vac. at 100°C; elem. anal.;	73%

Na(1+)*BrC6H4COCHNO(1-)=BrC6H4COCHNONa + cobalt(II) diacetate tetrahydrate (6147-53-1) → cobalt(II)(4-BrINAP)2*H2O

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

Na(1+)*CH3C6H4COCHNO(1-)=CH3C6H4COCHNONa + cobalt(II) diacetate tetrahydrate (6147-53-1) → cobalt(II)(4-MeINAP)2*H2O

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

Na(1+)*ClC6H4COCHNO(1-)=ClC6H4COCHNONa + cobalt(II) diacetate tetrahydrate (6147-53-1) → cobalt(II)(4-ClINAP)2*H2O

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

Na(1+)*NO2C6H4COCHNO(1-)=NO2C6H4COCHNONa + cobalt(II) diacetate tetrahydrate (6147-53-1) → cobalt(II)(4-NO2INAP)2*4-NO2HINAP (87036-30-4)

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

cobalt(II) diacetate tetrahydrate (6147-53-1) + iso-nitrosoacetophenone sodium salt (20597-98-2) → cobalt(II)(INAP)2 (87097-49-2)

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

cobalt(II) diacetate tetrahydrate (6147-53-1) + 2-(p-methoxyphenyl)ethan-1,2-dion-1-oxime sodium salt (151427-04-2) → cobalt(II)(4-OMeINAP)2*H2O

Conditions	Yield
In water addn. of a soln. of organic compound to a soln. of metal salt with stirring; filtn., washing (water), drying (anhydrous calcium chloride), elem. anal.;	100%

2-hydroxy-3-carboxypyridine (609-71-2) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) → diaquabis(2-hydroxynicotinato(1-))cobalt(II) (956331-98-9)

Conditions	Yield
With aq. ammonia In water soln. of ligand in H2O added to soln. of Co salt in H2O; pH adjusted to 8 (a few drops of concd. ammonia soln.); stored for a few d; filtered; ppt. washed with H2O; dried in dessicator over NaOH; elem. anal.;	100%

C102H120N6O6 (1412912-27-6) + cobalt(II) diacetate tetrahydrate (6147-53-1) → C102H114Co3N6O6

Conditions	Yield
In methanol; dichloromethane at 25℃; for 1.5h; Schlenk technique; Inert atmosphere;	100%

C136H160N8O8 (1412912-29-8) + cobalt(II) diacetate tetrahydrate (6147-53-1) → C136H152Co4N8O8

Conditions	Yield
In methanol; dichloromethane at 25℃; for 1.5h; Schlenk technique; Inert atmosphere;	100%

cobalt(II) diacetate tetrahydrate (6147-53-1) + [1,2]benzenobicyclo[2.2.2]octadieneporphyrin → [1,2]benzenobicyclo[2.2.2]octadieneporphyrin cobalt

Conditions	Yield
In methanol; chloroform for 3h;	100%

2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H3(OC2H5)OH)2)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H3(OC2H5)OH)2)2] + cobalt(II) diacetate tetrahydrate (6147-53-1) → 2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H3(OC2H5)O)2Co)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H3(OC2H5)O)2Co)2]

Conditions	Yield
In methanol; acetone byproducts: H2O; inert atmosphere; dropwise addn. of metal acetate (in MeOH) to 0.5 equiv. Mn-complex (in Me2CO), stirring for 1 h; solvent removal (vac.), dissoln. in THF/CH2Cl2=10:1, pptn. on Et2O addn., standing overnight;	99%

2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H2(C(CH3)3)2OH)2)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H2(C(CH3)3)2OH)2)2] + cobalt(II) diacetate tetrahydrate (6147-53-1) → 2N((CH2)3CH3)4(1+)*Mo2O5(O2C6H2(NCHC6H2(C4H9)2O)2Co)2(2-)=[N((CH2)3CH3)4]2[Mo2O5(O2C6H2(NCHC6H2(C4H9)2O)2Co)2]

Conditions	Yield
In methanol; acetone byproducts: H2O; inert atmosphere; dropwise addn. of metal acetate (in MeOH) to 0.5 equiv. Mn-complex (in Me2CO), stirring for 1 h; solvent removal (vac.), dissoln. in PhMe, pptn. on addn. of hexanes, standing overnight;	99%

4-palmitoyl-1-phenyl-3-methyl-2-pyrazolone (116655-21-1) + cobalt(II) diacetate tetrahydrate (6147-53-1) → Co(C6H5C3N2(CH3)(CO(CH2)14CH3)O)2*2H2O

Conditions	Yield
In ethanol; water warming a soln. of Co(CH3COO)2*4H2O in water, addn. of a hot ethanolic soln. of ligand with stirring, pptn.; washing with water/ethanol, drying in air, storing in a desiccator, elem. anal.;	99%

C20H10N4(C6H4NHC(O)C6H4CH2N2C3H2C6H4CF3)(C6H4NHC(O)CH3)3 + cobalt(II) diacetate tetrahydrate (6147-53-1) → Co[C20H8N4(C6H4NHC(O)C6H4CH2N2C3H2C6H4CF3)(C6H4NHC(O)CH3)3]

Conditions	Yield
In tetrahydrofuran N2; stirring of THF soln. of ligand and Co salt overnight at room temp.; evapn. of the solvent, chromy. on neutral Al2O3 (benzene/methanol, 90:10), evapn. of the solvent;	99%

ethanol (64-17-5) + dimethyl 2,2'-dihydroxy-1,1'-binaphthalene-3,3'-dicarboxylate (47644-69-9, 69678-00-8, 18531-91-4) + cobalt(II) diacetate tetrahydrate (6147-53-1) → [Co(EtOH)(H2O)(2,2'-dihydroxy-3,3'-di(carboxymethyl)-1,1'-binaphthyl(-2H))]2*H2O (1072832-01-9)

Conditions

Yield

With sodium acetate In ethanol; 1,2-dichloro-ethane byproducts: CH3COOH; addn. of soln. of Co(CH3COO)2*4H2O in 1,1'-dichloroethane to EtOH soln. of 2,2'-dihydroxy-2,2'-di(carboxymethyl)-1,1'-binaphthyl with stirring; reflux for 1 h; adjusting pH to 6.0 by addn. of NaCH3COO; heating at 90°C for 0.5 h; addn. of H2O; pptn., filtration, washing with hot EtOH; drying in desiccator over P4O10; elem. anal.;

99%

tetrahydrofuran (109-99-9) + cobalt(II) diacetate tetrahydrate (6147-53-1) + (1R,4R)-3-trifluoroacetyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one → bis[2,2,2-trifluoromethyl-1-[(1R,4S)-1,7,7-trimethyl-2-(oxo-κO)bicyclo[2.2.1]hept-3-yliden]ethanolato-κO]cobalt(II)*tetrahydrofuran*water

Conditions	Yield
In ethanol (under N2); soln. of ligand in EtOH added to suspn. of Co(CH3CO2)2*4H2O in EtOH, stirred for 30 min at 20°C; volatiles removed under reduced pressure, dried under reduced pressure, pentane diffused into THF soln.; elem. anal.;	99%

(1R,4R)-3-[1-[3,5-bis(trifluoromethyl)phenyl]]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one + cobalt(II) diacetate tetrahydrate (6147-53-1) → bis[1-[3,5-bis(trifluoromethyl)benzoyl]-1-[(1R,4S)-1,7,7-trimethyl-2-(oxo-κO)bicyclo[2.2.1]hept-3-yliden]methanolato-κO]cobalt(II)

Conditions	Yield
In sodium hydroxide; ethanol (under N2); soln. of ligand in EtOH and aq. NaOH added to suspn. of Co(CH3CO2)2*4H2O in EtOH and aq. NaOH, stirred for 30 min at 20°C; volatiles removed under reduced pressure, dried under reduced pressure;	99%

5-allyl-2-hydroxy-3-methoxybenzaldehyde (22934-51-6) + lutidinium p-toluene sulfonate + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) + cobalt(II) diacetate tetrahydrate (6147-53-1) → [((R,R)-C6H10(NCHC6H2(OMe)(allyl)O)2)Co(p-toluene sulfonate)]

Conditions	Yield
With air In ethanol refluxing mixt. of benzaldehyde deriv. and diamine deriv. in ethanol for30 min, cooling, addn. of cobalt compd. and then lutidinium salt, stirr ing at room temp. for 30 min; concg., addn. of CH2Cl2, filtration through celite, concg., addn. of hexane, filtration, drying in air, NMR and MS;	99%

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) + cobalt(II) diacetate tetrahydrate (6147-53-1) → bis-[1,1,1-trifluoro-4-phenyl-2-(oxo-κO)-but-3-en-4(olato-κO)]cobalt(II) dihydrate

Conditions	Yield
In ethanol 20°C;	99%

lutidinium p-toluene sulfonate + (R,R,R,R)-HO(tBu)2C6H2CHNC6H10NCHC6H2(OMe)(OH)CH2CHCHCH2C6H2(OMe)(OH)CHNC6H10NCHC6H2(tBu)2OH*Et3NHCl*3water + cobalt(II) diacetate tetrahydrate (6147-53-1) → [((R,R,R,R)-O(tBu)2C6H2CHNC6H10NCHC6H2(OMe)(O)CH2CHCHCH2C6H2(OMe)(O)CHNC6H10NCHC6H2(tBu)2O)Co2(p-toluene sulfonate)2]

Conditions	Yield
With air In methanol; dichloromethane addn. of degassed soln. of cobalt compd. in methanol to degassed soln. of phenol deriv. in CH2Cl2 under Ar, stirring for 30 min, addn. of tosylate salt, stirring for 18 h in air; concg., washing with diethyl ether, drying in vac., NMR and MS;	99%

[3,5-bis(4-methoxyphenyl)-1H-pyrrol-2-yl]-[3,5-bis(4-methoxyphenyl)pyrrol-2-ylidene]amine (873975-75-8) + cobalt(II) diacetate tetrahydrate (6147-53-1) → bis[3,5-bis(4-methoxyphenyl)-1H-pyrrol-2-yl-3,5-bis(4-methoxyphenyl)-2-ylideneamine]cobalt(II) (1407495-77-5)

Conditions	Yield
With potassium tert-butylate In butan-1-ol for 0.25h; Microwave irradiation;	99%

ethanol (64-17-5) + 2-(2-hydroxyphenyl)-4,5-diphenyl-1H-imidazole (14691-35-1) + cobalt(II) diacetate tetrahydrate (6147-53-1) → Co(2-(4,5-diphenyl-1H-imidazol-2-yl)phenol(-1H))2*2EtOH

Conditions	Yield
for 0.5h; Reflux;	99%

5,15-diphenylporphyrin (22112-89-6) + cobalt(II) diacetate tetrahydrate (6147-53-1) → [5,15-diphenylporphyrinato]cobalt(II) (204841-08-7)

Conditions	Yield
In N,N-dimethyl-formamide at 130℃; for 3h; Inert atmosphere;	99%

cobalt(II) diacetate tetrahydrate (6147-53-1) + 29H,31H-Phthalocyanine (574-93-6) → cobalt(II) phthalocyanine (3317-67-7)

Conditions	Yield
With butyl(2-hydroxyethyl)dimethylammonium acetate at 100℃; Ionic liquid; Inert atmosphere;	99%
With tributyl-amine In pentan-1-ol at 160℃; for 2h; Inert atmosphere;	20 mg

2,4-dibromo-6-{[2-(4,5-diphenyl-1H-imidazol-2-yl)phenylimino]methyl}phenol + cobalt(II) diacetate tetrahydrate (6147-53-1) → C56H36Br4CoN6O2

Conditions	Yield
In ethanol at 20℃; for 4h;	99%

Upstream product

• 64-17-5 ethanol 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 7440-48-4 cobalt 
• 759403-02-6 cobalt(II) carbonate 

Downstream Products

• 7440-48-4 cobalt 
• 158678-12-7 1-acetyl-2-methyl-3-cyclohexene-4-ylpyridinebis(dimethylglyoximato)cobalt(III) 
• 87036-29-1 cobalt(III)(4-MeINAP)3 
• 78528-08-2 Co(S₂C₂(CN)2)((C₆H₅)2PCH₂CH₂P(C₆H₅)2)NO 
• 75027-71-3 Co⁽²⁺⁾*((C₆H₅)2C₃N₂O₂)2^(2-) = Co[((C₆H₅)2C₃N₂O₂)2] 
• 81610-67-5 CuCo((C₆H₅CH₂)2CCH₂(NCHC₆H₃(O)CO₂)2)(H₂O)2*H₂O 

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