6322-49-2Relevant articles and documents
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Arbuzov,B.A. et al.
, (1970)
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Synthesis method of 4-chloro-2-butanone
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Paragraph 0027-0034, (2020/02/19)
The invention provides a synthesis method of 4-chloro-2-butanone. The synthesis method comprises main steps as follows: (1) cooling an organic solution of butyl ketone to 0-30 DEG C; (2) adding hydrogen chloride, and then, conducting a thermal insulation reaction at room temperature for 1-5 h; (3) washing a product with a washing liquid to be neutral; and (4) performing reduced pressure distillation to obtain a finished product of 4-chloro-2-butanone. The synthesis method of 4-chloro-2-butanone directly conducts an anti-Markovnikov addition reaction with butyl ketone and hydrogen chloride gasto produce the product synthesis method of 4-chloro-2-butanone, and the process produces little sewage and is suitable for industrial production.
Photolysis of Tp′Rh(CNneopentyl)(PhNCNneopentyl) in the presence of ketones and esters: Kinetic and thermodynamic selectivity for activation of different aliphatic C-H bonds
Jones, William D.,Parsons, Astrid M.
supporting information, p. 10945 - 10952 (2019/08/01)
The active fragment [Tp′Rh(CNneopentyl)], generated from the precursor Tp′Rh(CNneopentyl)(PhNCNneopentyl), underwent oxidative addition of substituted ketones and esters resulting in Tp′Rh(CNneopentyl)(R)(H) complexes (Tp′ = tris-(3,5-dimethylpyrazolyl)borate). These C-H activated complexes underwent reductive elimination at varying temperatures (24-70 °C) in C6D6 or C6D12. Using previously established kinetic techniques, the relative Rh-C bond strengths were calculated. Analysis of the relative Rh-C bond strengths vs. C-H bond strengths shows a linear correlation with slope RM-C/C-H = 1.22 (12). In general, α-substituents increase the relative Rh-C bond strengths compared to the C-H bond that is broken.
Regio- and stereoselective monoamination of diketones without protecting groups
Simon, Robert C.,Grischek, Barbara,Zepeck, Ferdinand,Steinreiber, Andreas,Belaj, Ferdinand,Kroutil, Wolfgang
supporting information; experimental part, p. 6713 - 6716 (2012/09/22)
Hitting the right target: Differentiation between two keto moieties was accomplished by a regio- and enantioselective bioamination employing ω-transaminases. Using 1,5-diketones as substrates gave access to the optically pure 2,6-disubstituted piperidine scaffold. The approach allowed the shortest synthesis of the alkaloid dihydropinidine, as well as its enantiomer, by choosing an appropriate ω-transaminase. Copyright
