72-80-0

Basic information

• Product Name: 5,7-Dichloro-8-hydroxyquinaldine
• Synonyms: 5,7-Dichloro-2-methyl-8-hydroxyquinoline;5,7-DICHLORO-8-QUINALDOL;5,7-Dichloro-8-hydroxy-2-methylquinoline;5,7-Dichloro-8-hydroxyquinalidine;Chlorquinalol;CHLORQUINALDOL(RG);2-METHYL-5,7-DICHLORO-8-HYDROXYQUINOLINE;5,7-DICHLORO-8-HYDROXYQUINALIDNE
• CAS NO: 72-80-0
• Molecular Formula: C₁₀H₇Cl₂NO
• Molecular Weight: 228.07
• EINECS: 200-789-3
• Product Categories: Pharmaceutical Intermediates;Quinoline&Isoquinoline;Antibiotics;Antibiotics A to Z;Antibiotics A-F;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinolines;SITOSTERAN
• Mol File: 72-80-0.mol

Chemical Properties

• Melting Point: 108-112 °C (dec.)(lit.)
• Boiling Point: 350.7 °C at 760 mmHg
• Flash Point: 165.9 °C
• Appearance: yellowish to beige-brown powder
• Density: 1.3126 (rough estimate)
• Vapor Pressure: 2.13E-05mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: 2-8°C
• Solubility: DMSO, Methaol (Slightly)
• PKA: 2.47±0.30(Predicted)
• Water Solubility: Insoluble
• Merck: 13,2209
• BRN: 156683
• CAS DataBase Reference: 5,7-Dichloro-8-hydroxyquinaldine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dichloro-8-hydroxyquinaldine(72-80-0)
• EPA Substance Registry System: 5,7-Dichloro-8-hydroxyquinaldine(72-80-0)

Safety Data

• Hazard Codes: Xn,T
• Statements: 22-36/37/38-23/24/25
• Safety Statements: 26-36-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: VC5600000
• Hazardous Substances Data: 72-80-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,7-Dichloro-8-hydroxyquinaldine is used as an anti-infective agent for its fungistatic and antibacterial properties. It is commonly found in topical pharmaceutical preparations, such as Sterosan, to treat various skin infections and conditions caused by fungi and bacteria.
Used in Antimicrobial Applications:
5,7-Dichloro-8-hydroxyquinaldine is used as an anti-infectant and antifungal agent due to its ability to inhibit the growth of microorganisms. This makes it suitable for use in various industries where controlling microbial growth is essential, such as in cosmetics, personal care products, and household cleaning products.

Originator

Sterosan ,Geigy ,US ,1954

Manufacturing Process

11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid. Chlorine is introduced into this solution under cooling, until the increase in weight corresponds to the required quantity of chlorine and a test of the chlorination mixtures gives no more dyestuff formation with diazo-benzene in an acetic acid solutionWhen the chlorination is complete, the reaction mixture is poured into 1,000 parts of water and treated with a dilute sodium bisulfite solution, until no more reaction may be observed with starch potassium iodide paper. Thereby the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly yellowish colored precipitate. The same is filtered off and thoroughly washed with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C to 112°C are obtained. When recrystallized from alcohol, the product is obtained in voluminous, slightly yellowish needles having the melting point of 111.5°C to 112°C.

Therapeutic Function

Antibacterial

Purification Methods

Crystallise it from EtOH. [Beilstein 21/3 V 346.]

InChI:InChI=1/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3

Synthetic route

2-methyl-8-quinolinol (826-81-3) → chloroquinaldol (72-80-0)

Conditions	Yield
With aluminum (III) chloride; N-chloro-succinimide In dichloromethane at 35℃; for 8h; Temperature; Solvent; Darkness; Green chemistry;	98.8%
With hydrogenchloride; chlorine In water Reagent/catalyst; Inert atmosphere; Darkness;	98.9%
With hydrogenchloride; sodium hypochlorite In water at 20 - 30℃; for 4.5h; Temperature;	97.7%

5,7-dichloro-8-hydroxyquinoline 1-oxide (21168-33-2) + methylmagnesium chloride (676-58-4) → chloroquinaldol (72-80-0)

Conditions	Yield
With copper(l) chloride; magnesium chloride In diethyl ether at 23℃; for 12h; Grignard Reaction; Inert atmosphere;	63%

2-methyl-8-quinolinol (826-81-3) + dichlorohydantoin (4369-36-2) → chloroquinaldol (72-80-0)

Conditions	Yield
With acetic acid for 3h; Cooling with ice;

chloroquinaldol (72-80-0) → 5,7-dichloro-8-hydroxy-2-quinolinecarboxaldehyde (24010-07-9)

Conditions	Yield
With selenium(IV) oxide In 1,4-dioxane at 50 - 80℃; for 3h;	100%
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;	80%
With selenium(IV) oxide In 1,4-dioxane at 55 - 80℃;	2.1 g
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 12h;

chloroquinaldol (72-80-0) → 5,7-dichloro-2-methyl-quinoline-8-oxysulfonyl fluoride

Conditions	Yield
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h;	97%
Stage #1: chloroquinaldol With triethylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile for 1h; Inert atmosphere;	97%

chloroquinaldol (72-80-0) + tert-butylphenylphosphinic acid chloride (4923-85-7) → 5,7-dichloro-2-methylquinolin-8-yl tert-butyl(phenyl)posphinate (1227180-25-7)

Conditions	Yield
With sodium hydride In tetrahydrofuran for 24h; Reflux; Inert atmosphere;	96%

{Ir(mppy)2Cl}2 + chloroquinaldol (72-80-0) → C34H26Cl2IrN3O

Conditions	Yield
In ethanol; acetone at 85℃; for 5h; Solvent; Temperature;	95.3%

diiodo(p-cymene)ruthenium(II) dimer + chloroquinaldol (72-80-0) → [(η6-p-cymene)Ru(2-methyl-5,7-dichloro-8-hydroxyquinolinato)I]

Conditions	Yield
In methanol; dichloromethane at 65℃; for 6h; Reflux;	95.2%

chloroquinaldol (72-80-0) + cis-dichlorobis(dimethylsulfoxide)platinum(II) (75992-73-3, 25794-47-2, 30729-25-0, 15274-33-6, 22840-91-1, 14568-13-9) → C12H12Cl3NO2PtS

Conditions	Yield
In methanol; dimethyl sulfoxide at 80℃; for 12h; Solvent; Temperature;	95%

chloroquinaldol (72-80-0) + methyl iodide (74-88-4) → 5,7-dichloro-8-methoxy-2-methylquinoline (1053246-24-4)

Conditions	Yield
Stage #1: chloroquinaldol With potassium tert-butylate In tetrahydrofuran for 3h; Reflux; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;	94%
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 40℃; for 30h;	83%

chloroquinaldol (72-80-0) + 3,5-dihydroxybenzaldehyde (26153-38-8) → 5,7-dichloro-2-[2-(3,5-dihydroxyphenyl)vinyl]quinolin-8-ol (1251918-08-7)

Conditions	Yield
Stage #1: chloroquinaldol; 3,5-dihydroxybenzaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	93%

chloroquinaldol (72-80-0) + 2-hydroxy-5-acetyloxybenzaldehyde (64418-88-8) → 5,7-dichloro-2-[2-(2-hydroxy-5-acetoxyphenyl)vinyl]quinolin-8-ol

Conditions	Yield
Stage #1: chloroquinaldol; 2-hydroxy-5-acetyloxybenzaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	93%

bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] (12354-84-6, 12354-85-7) + chloroquinaldol (72-80-0) → C20H21Cl3IrNO

Conditions	Yield
With potassium carbonate In dichloromethane at 20℃; under 760.051 Torr; for 12h;	93%

chloroquinaldol (72-80-0) + 5-acetoxy-2-nitro-benzaldehyde (76143-12-9) → (E)-2-(5-acetoxy-2-nitrostyryl)-5,7-dichloroquinolin-8-yl acetate

Conditions	Yield
at 150℃;	92%

chloroquinaldol (72-80-0) + acetic anhydride (108-24-7) → 8-acetoxy-5,7-dichloro-2-methylquinoline (27039-48-1)

Conditions	Yield
With pyridine at 0 - 20℃; for 6h;	91%

chloroquinaldol (72-80-0) → 8-hydroxy-5,7-dichloro-2-(d3)methylquinoline

Conditions	Yield
With water-d2; benzoic acid at 120℃; for 4h;	91%
With water-d2; benzoic acid at 120℃; for 16h; Inert atmosphere; Schlenk technique;

chloroquinaldol (72-80-0) + 2-nitro-benzaldehyde (552-89-6) → (E)-5,7-dichloro-2-(2-nitrostyryl)quinolin-8-yl acetate

Conditions	Yield
at 150℃;	91%

chloroquinaldol (72-80-0) + benzyl bromide (100-39-0) → 8-(benzyloxy)-5,7-dichloro-2-methylquinoline (24010-00-2)

Conditions	Yield
With potassium carbonate In acetone for 5h; Reflux;	91%

chloroquinaldol (72-80-0) + 2,4-dinitrobenzaldehyde (528-75-6) + acetic anhydride (108-24-7) → 5,7-dichloro-2-[2-(2,4-dinitrophenyl)vinyl]quinolin-8-yl acetate

Conditions	Yield
With acetic acid at 130℃; Inert atmosphere;	91%

4,7-dichloro-1,10-phenanthroline (5394-23-0) + chloroquinaldol (72-80-0) + cobalt(II) salt → C32H18Cl6CoN4O2

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	90.8%

chloroquinaldol (72-80-0) + dipyrazine[2,3-f:2’,3’-h]quinoxaline (217-90-3) + cobalt(II) salt → C34H20Cl4CoN6O2

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	90.5%

[iridium(III)(μ-chloro)(2-phenylpyridine)2]2 + chloroquinaldol (72-80-0) → C32H22Cl2IrN3O

Conditions	Yield
In ethanol; water at 70℃; for 12h; Solvent; Temperature;	90.21%

sodium tetrafluoroborate (13755-29-8) + [RuCl2(hexamethylbenzene)]2 + chloroquinaldol (72-80-0) → [(η6-hexamethylbenzene)Ru(η2-N,O-5,7-dichloro-2-methyl-8-hydroxyquinolate)(H2O)]BF4 (1202404-57-6)

Conditions	Yield
With Ag2SO4 In water under inert atm.; mixt. of ((C6(CH3)6)RuCl2)2 (0.082 mmol) and Ag2SO4 (0.163 mmol) in H2O stirred for 2 h in dark at room temp., soln. filtered,NC9H3Cl2MeOH (0.163 mmol) added, stirred for 2 h in dark at room temp., pptd. by satd. aq. soln. of NaBF4; crystd. from H2O; elem. anal.;	90%

chloroquinaldol (72-80-0) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (5,7-dichloro-2-methylquinolin-8-yl)carbonate

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;	90%
With dmap; triethylamine In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;	90%

dipyridil[3,2-a:2',3'-c]phenazine (19535-47-8) + chloroquinaldol (72-80-0) + cobalt(II) salt → C38H22Cl4CoN6O2

Conditions	Yield
In methanol; acetonitrile at 80℃; for 24h;	89.2%

4,4'-dimethyl-2,2'-bipyridines (1134-35-6) + chloroquinaldol (72-80-0) + ytterbium(III) nitrate hexahydrate → [Yb(4,4'-dimethyl-2,2'-bipyridyl)(ClQ)2NO3]

Conditions	Yield
at 80℃; for 72h;	89.11%

chloroquinaldol (72-80-0) + 2,4-dichloro-6-formylphenyl acetate (1309272-63-6) + acetic anhydride (108-24-7) → 5,7-dichloro-2-[2-(2-acetoxy-3,5-dichlorophenyl)vinyl]quinolin-8-yl acetate

Conditions	Yield
With acetic acid at 130℃; Inert atmosphere;	88%

chloroquinaldol (72-80-0) + salicylaldehyde (90-02-8) → 5,7-dichloro-2-[2-(2-hydroxyphenyl)vinyl]quinolin-8-ol (1415220-29-9)

Conditions	Yield
Stage #1: chloroquinaldol; salicylaldehyde With acetic anhydride for 24h; Reflux; Stage #2: With pyridine In water for 3h; Reflux;	87%

chloroquinaldol (72-80-0) + trimethyl gallium (1445-79-0) → (5,7-dichloro-2-methyl-8-quinolinolato)dimethyl gallium

Conditions	Yield
In toluene at 24.84℃; for 16h; Inert atmosphere;	87%

chloroquinaldol (72-80-0) → 5,7-dichloro-8-hydroxy-2-methylquinoline 1-oxide (63504-03-0)

Conditions	Yield
With phosphoric acid; dihydrogen peroxide; molybdenum(VI) oxide In water; acetonitrile at 50℃;	87%

chloroquinaldol (72-80-0) + 5-fluoro-2-nitrobenzaldehyde (395-81-3) → (E)-5,7-dichloro-2-(5-fluoro-2-nitrostyryl)quinolin-8-yl acetate

Conditions	Yield
at 150℃;	87%

chloroquinaldol (72-80-0) + 2-nitroveratraldehyde (20357-25-9) → (E)-5,7-dichloro-2-(4,5-dimethoxy-2-nitrostyryl)quinolin-8-yl acetate

Conditions	Yield
at 150℃;	87%

Upstream product

• 826-81-3 2-methyl-8-quinolinol 
• 21168-33-2 5,7-dichloro-8-hydroxyquinoline 1-oxide 
• 676-58-4 methylmagnesium chloride 
• 118-52-5 1,3-dichloro-5,5-dimethylhydantoin 
• 507-40-4 tert-butylhypochlorite 
• 4369-36-2 dichlorohydantoin 

Downstream Products

• 1053246-32-4 8-acetoxy-5,7-dichloro-2-[2-(3,4,5-trimethoxyphenyl)vinyl]quinoline 
• 1251918-08-7 5,7-dichloro-2-[2-(3,5-dihydroxyphenyl)vinyl]quinolin-8-ol 
• 1415220-30-2 5,7-dichloro-2-[2-(4-hydroxyphenyl)vinyl]quinolin-8-ol 
• 1415220-29-9 5,7-dichloro-2-[2-(2-hydroxyphenyl)vinyl]quinolin-8-ol 
• 1251918-07-6 5,7-dichloro-2-[2-(2,4-dihydroxyphenyl)vinyl]quinolin-8-ol 
• 1227180-25-7 5,7-dichloro-2-methylquinolin-8-yl tert-butyl(phenyl)posphinate 
• 1415222-54-6 C₃₅H₂₄Cl₅NO₂PRe 
• 1415222-58-0 C₃₅H₂₄Br₂Cl₃NO₂PRe 
• 796860-41-8 5,7-dichloro-2-[2-(2-chlorophenyl)vinyl]quinoline-8-ol 
• 1416988-91-4 C₂₂H₂₃Cl₃N₂O 
• 1415220-31-3 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol 

Relevant articles and documents

Preparation method of chlorquinaldol

The invention provides a preparation method of chloroquinaldoll. The preparation method comprises the following step: in the presence of a catalyst Lewis acid, carrying out a reaction I on a material containing 8-hydroxy-2-methylquinoline and tert-butyl hypochlorite to obtain the chloroquinaldol. According to the method, the tert-butyl hypochlorite is used for replacing chlorine to serve as a reaction raw material, so good selectivity is achieved, byproducts are few, reaction operability is strong, light shielding and gas protection are not needed, quality and yield are improved, the purity of chlorquinaldol is 99.00% or more, and the quality of chlorquinaldol is ensured. In the reaction process, generation of waste liquid is reduced, pollution to the environment is avoided to the maximum extent, cost is saved, quality is improved, and the method is an environment-friendly process suitable for industrial production.

Preparation method of chlorquinaldol

The invention provides a preparation method of chlorquinaldol. The preparation method comprises the following step: in the presence of a catalyst Lewis acid, subjecting a material I containing 8-hydroxy-2-methylquinoline and dichlorohydantoin to reacting so as to obtain the chlorquinaldol. According to the invention, dichlorohydantoin is used as a reaction raw material to replace chlorine, so good selectivity is achieved, byproducts are few, reaction operability is strong, light shielding and gas protection are not needed, quality and yield are improved, the purity of chlorquinaldol is 99.00% or more, and the quality of chlorquinaldol is ensured. In the reaction process, generation of waste liquid is reduced, pollution to the environment is avoided to the maximum extent, cost is saved, quality is improved, and the method is an environment-friendly process suitable for industrial production.

Preparation method of chloroquinaldol

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of chloroquinaldol. The preparation method comprises the following steps: adding water intochloroquinaldol hydrochloride for dissolving, adding a buffer solution under the conditions of light shielding and nitrogen protection, regulating the pH value by using alkali, filtering and refiningthe solution to obtain chloroquinaldol. The method is easy and convenient to operate and suitable for industrial production, the purity of the prepared chloroquinaldol is high and can reach 99.99% orabove, and the stability of the product is high.

Rare earth complex constructed based on 2- methyl -5,7- dichloro -8- hydroxyquinoline, and preparation method and application thereof

The rare earth complex constructed based on 2 - methyl - 55557-dichloro - 8 8-hydroxyquinoline and a preparation method and application. of the rare earth complex are respectively a complex 1 and a complex 2, complex 1. [Er(ClQ). 3 (H2 O)], Complex 2 has a molecular formula of [Ho(ClQ). 3 (H2 A test result of O)], ClQ of 2 - methyl - 55557-dichloro - 8 8-dichloro - 8 8-hydroxyquinoline and erbium nitrate hexahydrate or holmium nitrate hexahydrate, are reacted. under a heating condition of: respectively. 2 - The test result shows, that the rare earth complex has a remarkable anti-proliferative effect on a plurality of tumor cells, and is expected to be developed into anti-tumor medicines pH＝7.7 - 8.2 by using, a mixed solvent dissolving, at a heating condition.

Synthetic technology of chlorquinaldol

The invention belongs to the field of pharmaceutical synthesis technology and specifically relates to a synthetic technology of chlorquinaldol. By using Lewis acid as a catalyst, 8-hydroxy-2-methylquinoline and N-Chlorosuccinimide, which are used as raw materials, are subjected to a one-step chlorination reaction to generate chlorquinaldol; and after the reaction, chlorquinaldol is refined to obtain the chlorquinaldol. By using N-Chlorosuccinimide to replace chlorine as the raw material of the chlorination reaction, the selectivity is good, side reaction is reduced, conversion rate and yield are increased, yield reaches 98.2% and above, purity is 99.90% and above, quality of the chlorquinaldol is guaranteed, generation of spend liquor is decreased, environmental pollution is reduced, the cost is saved, water dissolution of the reaction product is avoided, and the yield is increased. The technology of the invention is a green and environmentally-friendly technology, and is suitable forindustrial production.

To 2 - methyl - 5, 7 - dichloro -8 - hydroxy quinoline as ligands of the single nucleus arrowhead complex and its preparation method and application

The invention discloses a mononuclear dysprosium complex using 2-methyl-5,7-dichloro-8-hydroxyquinoline as a ligand and a preparation method and application thereof. A chemical formula of the complex is: [Dy(L)3(HL)], wherein L represents a product obtained after hydrogen atom of hydroxyl is removed from 2-methyl-5,7-dichloro-8-hydroxyquinoline, and has one unit of negative charges; HL represents 2-methyl-5,7-dichloro-8-hydroxyquinoline; the complex belongs to a triclinic system and a P-1 space group. The preparation method of the complex, which is disclosed by the invention, comprises: taking Dy(NO3)3.6H2O and 2-methyl-5,7-dichloro-8-hydroxyquinoline; dissolving Dy(NO3)3.6H2O and 2-methyl-5,7-dichloro-8-hydroxyquinoline with methanol; regulating pH of the obtained solution into a range of 6.5 to 7.8; performing a reaction on the obtained mixed solution under the heating condition to obtain the mononuclear dysprosium complex. The complex provided by the invention is simple in preparation method, low in cost and good in repeatability, shows a field-induced slow relaxation magnetic behavior at a low temperature, and can be used for preparing a magnetic material.

Process for synthesizing chlorquinaldol

The invention belongs to the technical field of medicine synthesis, and particularly relates to a process for synthesizing chlorquinaldol. The process comprises the following steps: carrying out reaction between 8-hydroxyl-2-methylquinoline as a raw material and sodium hypochlorite and hydrochloric acid to generate active chlorine atoms as a chlorinated material; performing one-step chlorinated reaction to generate the chlorquinaldol. According to the process disclosed by the invention, using chlorine as a chlorinated material is avoided, and chlorquinaldol is quantitatively generated, so thatthe selectivity and the yield of chlorinated reaction are improved, and meanwhile, the phenomena that pollution on the environment by adopting the chloride and side reaction caused by performing thechlorinated reaction adopting the chloride as the chlorinated material are avoided, and the quality of the chlorquinaldol is ensured.

Mononuclear dysprosium complex using 2-methyl-5,7-dichloro-8-hydroxyquinoline as ligand and preparation method and application thereof

The invention discloses a mononuclear dysprosium complex using 2-methyl-5,7-dichloro-8-hydroxyquinoline as ligand and a preparation method and application thereof. The chemical formula of the complex is [Dy(L)4].(H2O)(DMF)(HN(C2H5)3), wherein L represents 2-methyl-5,7-dichloro-8-hydroxyquinoline without hydroxyl hydrogen atoms and provided with a unit of negative charges, DMF is N,N-dimethylformamide, and the complex belongs to a P21/n space group of a monoclinic crystal system. The complex is obtained by dissolving Dy(NO3)3.6H2O and the 2-methyl-5,7-dichloro-8-hydroxyquinoline with mixed solvents, regulating the pH of the obtained solution to be 6.5 to 7. 8 and making the mixed solution react under the heating conditions. The preparation method of the complex is simple, cheap and good in repeatability, shows field induced slow relaxation magnetic behavior at low temperature and can be used for preparing magnetic materials.

Based on 2 - methyl - 5, 7 - dichloro - 8 - hydroxy quinoline as ligands of the single nucleus arrowhead complex and its preparation method and application (by machine translation)

The invention discloses a method based on 2 - methyl - 5, 7 - dichloro - 8 - hydroxy quinoline as ligands of the single nucleus arrowhead complex and its preparation method and application. The complex chemical formula is: [Dy (L)3 (H2 O)], wherein L is 2 - methyl - 5, 7 - dichloro - 8 - hydroxy quinoline hydroxyl group to hydrogen atom, with a unit of negative charge; this complex belongs to the triclinic system, P - 1 space group. The invention for the preparation of the complexes: taking Dy (NO3 )3 · 6 H2 O and 2 - methyl - 5, 7 - dichloro - 8 - hydroxy quinoline, dissolved in water, the resulting solution to adjust the pH=6.5 - 7.8, the mixed liquid obtained by reaction under heating condition, to obtain. The present invention provides a complex preparation method is simple, low cost, repeatability is good, at the low temperature performance is field-induced slow relaxation magnetism acts, can be used for preparing magnetic material. (by machine translation)

Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N -Heterocycles from n -oxides

A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of copper catalysis and activation by lithium fluoride or magnesium chloride. The utility of this method for the late-stage modification of complex N-heterocycles is exemplified by facile syntheses of new structural analogues of several antimalarial, antimicrobial, and fungicidal agents.