76183-10-3Relevant articles and documents
Access to optically pure β-hydroxy esters via non-enzymatic kinetic resolution by a planar-chiral DMAP catalyst
Daz-lvarez, Alba E.,Mesas-Snchez, Laura,Dinr, Peter
, p. 14273 - 14291 (2014/12/11)
The development of new approaches to obtain optically pure β-hydroxy esters is an important area in synthetic organic chemistry since they are precursors of other high value compounds. Herein, the kinetic resolution of racemic β-hydroxy esters using a planar-chiral DMAP derivative catalyst is presented. Following this procedure, a range of aromatic β-hydroxy esters was obtained in excellent selectivities (up to s = 107) and high enantiomeric excess (up to 99% ee). Furthermore, the utility of the present method was demonstrated in the synthesis of (S)-3-hydroxy-N-methyl-3-phenylpropanamide, a key intermediate for bioactive molecules such as fluoxetine, tomoxetine or nisoxetine, in its enantiomerically pure form.
Copper-Catalyzed conjugate addition of diboron reagents to α,β-unsaturated amides: Highly reactive copper-1,2- bis(diphenylphosphino)benzene catalyst system
Chea, Heesung,Sim, Hak-Suk,Yun, Jaesook
supporting information; experimental part, p. 855 - 858 (2009/10/25)
An efficient copper catalyst system for the β-boration of α,β-unsaturated amides has been developed. Copper-bisphosphine complexes with small bite angles generate efficient catalyst systems for the successful conjugate addition of bis(pinaco-lato)diboron
Ru-SYNPHOS and Ru-DIFLUORPHOS: Highly efficient catalysts for practical preparation of β-hydroxy amides
Touati, Ridha,Gmiza, Thouraya,Jeulin, Séverine,Deport, Coralie,Ratovelomanana-Vidal, Virginie,Ben Hassine, Béchir,Genet, Jean-Pierre
, p. 2478 - 2482 (2007/10/03)
Ru-SYNPHOS and Ru-DIFLUORPHOS catalysts were efficiently used for the synthesis of a wide variety of chiral β-hydroxy amides via asymmetric hydrogenation of the corresponding β-keto amides. Georg Thieme Verlag Stuttgart.
