7680-73-1Relevant articles and documents
Method for synthesizing mepiquat chloride original medicine
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Paragraph 0037-0039; 0048; 0057; 0066, (2017/07/19)
The invention discloses a method for synthesizing a mepiquat chloride original medicine. The method comprises the following steps: adding ethanol into a container, adding pyridine for mixing, adding chloromethane after dissolution, and performing heating reaction to obtain N-methylpyridine chloride; adding the N-methylpyridine chloride and a catalyst into a reaction container, introducing hydrogen, performing heating reaction to obtain an N-methylpiperidine hydrochloride system, adding an acid binding agent into the N-methylpiperidine hydrochloride system for neutralization reaction, and performing filtering to obtain N-methylpiperidine; dissolving the N-methylpiperidine in ethanol, and adding chloromethane for heating reaction; evaporating a reaction system to remove the ethanol and the chloromethane to obtain a high-purity mepiquat chloride product. According to the method, the using amount of the acid binding agent is reduced in a production process, and the water cost for production is reduced; in addition, the sustainability is high, the energy consumption is effectively reduced, and the method is a novel production process. Therefore, the method has remarkable economic benefits and social benefits.
Monotopic and heteroditopic calix[4]arene receptors as hosts for pyridinium and viologen ion pairs: A solution and solid-state study
Pescatori, Luca,Arduini, Arturo,Pochini, Andrea,Secchi, Andrea,Massera, Chiara,Ugozzoli, Franco
experimental part, p. 3698 - 3708 (2009/10/23)
The binding efficiency of a series of monotopic (1-2) and heteroditopic (3-4) calix[4]arene-based receptors has been evaluated in chloroform solution toward N-methylpyridinium ion pairs using NMR and UV/vis spectroscopic techniques. These experiments provided evidence that, due to a positive cooperative effect, the presence of a phenylurea H-bond donor group on the upper rim of the calix[4]arene macrocycle increases the recognition abilities of the heteroditopic receptors by up to two orders of magnitude with respect to the monotopic receptors. The heteroditopic receptors are also able to form 2:1 host-guest inclusion complexes with dimethylviologen salts both in low polarity solvents and in the solid state. These complexes are stabilized through the cooperation of weak (CH-π and cation-π) and strong (hydrogen bonding) intramolecular interactions between the binding domains of the calix[4]arene host and the two ions of the guest ion pair.
The chemistry of the N-methyl-3-dehydropyridinium ylid
Pan, Weitao,Shevlin, Philip B.
, p. 5091 - 5094 (2007/10/03)
The reaction of atomic carbon with N-methylpyrrole, 5b, at 77 K generates the N-methyl-3-dehydropyridinium ylid, 6b, which can be trapped with added hydrogen halides or CO2. The addition of CO2 is strong evidence for the ylid 6b rather than cumulene 7. Deuterium and 13C labeling studies demonstrate that 6b rapidly rearranges to the N-methyl-2-dehydropyridinium ylid, 13, by an intermolecular mechanism. Ylid 13 can be trapped with added acids or with O2 to form 1-methyl-2-pyridone.
