7774-74-5Relevant articles and documents
Push-pull-substituted oligo(2,5-thienyleneethynylene)s
Muehling, Bastian,Theisinger, Sonja,Meier, Herbert
, p. 1009 - 1015 (2006)
Oligo(2,5-thienyleneethynylene)s (OTE) with terminal donor-acceptor substitution were synthesized by applying Sonogashira-Hagihara reactions and a protection group technique. The combination of the alkylthio and nitro substituents provides a DAOTE series, whose long-wavelength absorption shows a monotonous bathochromic effect for increasing numbers n of repeat units. The convergence limit is already reached for n = 3. Georg Thieme Verlag Stuttgart.
A successful chemical strategy to induce oligothiophene self-assembly into fibers with tunable shape and function
Di Maria, Francesca,Olivelli, Pasquale,Gazzano, Massimo,Zanelli, Alberto,Biasiucci, Mariano,Gigli, Giuseppe,Gentili, Denis,D'Angelo, Pasquale,Cavallini, Massimiliano,Barbarella, Giovanna
supporting information; experimental part, p. 8654 - 8661 (2011/07/29)
Functional supramolecular architectures for bottom-up organic nano- and microtechnology are a high priority research topic. We discovered a new recognition algorithm, resulting from the combination of thioalkyl substituents and head-to-head regiochemistry of substitution, to induce the spontaneous self-assembly of sulfur overrich octathiophenes into supramolecular crystalline fibers combining high charge mobility and intense fluorescence. The fibers were grown on various types of surfaces either as superhelices or straight rods depending on molecular structure. Helical fibers directly grown on a field effect transistor displayed efficient charge mobility and intrinsic 'memory effect'. Despite the fact that the oligomers did not have chirality centers, one type of hand-helicity was always predominant in helical fibers, due to the interplay of molecular atropisomerism and supramolecular helicity induced by terminal substituents. Finally, we found that the new sulfur overrich oligothiophenes can easily be prepared in high yields through ultrasound and microwave assistance in green conditions.
Investigation of the aroma-active compounds formed in the maillard reaction between glutathione and reducing sugars
Lee, Sang Mi,Jo, Ye-Jin,Kim, Young-Suk
experimental part, p. 3116 - 3124 (2011/08/05)
Aroma-active compounds formed during the thermal reaction between glutathione (GSH) and reducing sugars were analyzed by gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry (GC-O) with aroma extract dilution analysis (AEDA). Application of AEDA to glutathione Maillard reaction products (GSH MRPs) led to the identification of 19 aroma-active compounds in the thermal reaction of glutathione with glucose or fructose. In addition, the carbohydrate module labeling (CAMOLA) approach was also employed to elucidate the formation pathways for selected target sulfur aroma compounds, such as 5-methylthiophene-2-carbaldehyde and 3-methylthiophene-2-carbaldehyde, which have not been reported previously. The intact carbon skeleton of glucose via 3-deoxyhexosone is incorporated into 5-methylthiophene-2-carbaldehyde with the hydrogen sulfide of GSH. On the other hand, the formation of 3-methylthiophene2-carbaldehyde may occur via the recombination of a C-4 sugar fragment and mercaptoacetaldehyde.
PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE
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Page/Page column 18-19; 24-25, (2010/06/17)
The present invention relates to an improved process for the preparation of (4S,6S)-4- (ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide hydrochloride ("Dorzolamide hydrochloride") having formula 1. Dorzolamide hydrochloride is prepared by the process of the present invention with high chemical and diastereomeric purity. The present invention also relates to novel intermediate of the formula 20 and a process for its preparation. Dorzolamide hydrochloride is useful in the treatment of ocular hypertension by inhibiting carbonic anhydrase enzyme.
A simple, fast and chemoselective method for the preparation of arylthiols
Bellale, Eknath V.,Chaudhari, Mahesh K.,Akamanchi, Krishnacharya G.
experimental part, p. 3211 - 3213 (2010/03/01)
An efficient and convenient method for the synthesis of arylthiols by reaction of sulfonyl chlorides with triphenylphosphine in toluene is reported.
Synthesis of sulphur compounds: Regioselective synthesis of thieno[2,3-b]thiophenes by sulfoxide rearrangement
Majumdar,Pal,Samanta
, p. 667 - 675 (2008/02/04)
A number of thieno[2,3-b]thiophenes have been successfully synthesized in a 50-55% yield by m-chloroperoxybenzoic acid-mediated tandem cyclization involving [2, 3] and [3, 3] sigmatropic rearrangements and an intramolecular Michael addition. Copyright Taylor & Francis Group, LLC.
Gas-phase reaction of 2-chlorothiophene with hydrogen sulfide in the presence of alcohols
Deryagina,Sukhomazova,Levanova
, p. 40 - 45 (2007/10/03)
The effect of methanol and ethanol on the route of the gas-phase reaction of 2-chlorothiophene with hydrogen sulfide, leading to 2-thiophenethiol and to bis(2-thienyl) sulfide, has been investigated. It was found that methanol significantly enhances this
Polyhydroxyalkanoate and method of producing same, and omega-(2-thienylsulfanyl) alkanoic acid and method of producing same
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, (2008/06/13)
PHA containing a novel 3-hydroxy-thioalkanoic acid unit having a highly reactive thienyl group in a side chain thereof, and a method of producing the same are provided. Specifically, 5-(2-thienylsulfanyl) valeric acid represented by Chemical Formula [4] below and 6-(2-thienylsulfanyl) hexanoic acid represented by Chemical Formula [5] below are provided. Further, a method of producing PHA, comprising the step of collecting PHA from cells of a microorganism cultured in a medium containing the valeric acid or hexanoic acid, and a novel PHA represented by Chemical Formula [1] below are provided.(n denotes an integer of 1 to 9)
4-Hydroxy-5,6-dihydro-2H-pyran-2-ones. 3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S1' of the HIV-1 protease enzyme
Ellsworth, Edmund L.,Domagala, John,Vara Prasad,Hagen, Susan,Ferguson, Donna,Holler, Tod,Hupe, Donald,Graham, Neil,Nouhan, Caroline,Tummino, Peter J.,Zeikus, Greg,Lunney, Elizabeth A.
, p. 2019 - 2024 (2007/10/03)
56-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease which bind to the S1 S2 S1' S2' pockets have a unique binding mode with the catalytic aspartyl groups the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S1' S2' pockets have provided a number of selected analogs that display high HIV-1 protease inhibitory activity.
New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes
Cauquil-Caubere, Isoline,Kamenka, Jean-Marc
, p. 867 - 877 (2007/10/03)
4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro- benzothiophen-4-ylamines, and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4- ylamines were designed, synthesized, and tested as OH radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate.
