7774-74-5Relevant articles and documents
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Voronkov et al.
, (1974)
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Preparation of oligo(thio-2,5-thienylenes)
Nakayama, Juzo,Katano, Naoki,Shimura, Yoshiaki,Sugihara, Yoshiaki,Ishii, Akihiko
, p. 7608 - 7610 (1996)
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PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE
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Page/Page column 18-19; 24-25, (2010/06/17)
The present invention relates to an improved process for the preparation of (4S,6S)-4- (ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide hydrochloride ("Dorzolamide hydrochloride") having formula 1. Dorzolamide hydrochloride is prepared by the process of the present invention with high chemical and diastereomeric purity. The present invention also relates to novel intermediate of the formula 20 and a process for its preparation. Dorzolamide hydrochloride is useful in the treatment of ocular hypertension by inhibiting carbonic anhydrase enzyme.
A simple, fast and chemoselective method for the preparation of arylthiols
Bellale, Eknath V.,Chaudhari, Mahesh K.,Akamanchi, Krishnacharya G.
experimental part, p. 3211 - 3213 (2010/03/01)
An efficient and convenient method for the synthesis of arylthiols by reaction of sulfonyl chlorides with triphenylphosphine in toluene is reported.