78-26-2 Usage
Synthesis
2-Methyl-2-pentenal was hydrogenated at 100°C and 1.3-1.5MPa with a yield of 80%. After obtaining 2-methylpentenal, it was added to 36% formaldehyde, and the reaction was carried out at room temperature. Sodium hydroxide solution was added dropwise. The reaction was exothermic, and the temperature was naturally raised to 70 °C, then heated to 90 °C, added for 1 h, cooled to 60 °C and left to separate layers. The upper layer was washed with water, the washings were combined with the lower layer, and extracted with benzene. The extract and the upper layer were combined, and benzene was recovered by distillation, followed by distillation under reduced pressure to collect a fraction at 160°C (14.7kPa), which was 2-methyl-2-propyl-1,3-propanediol,yield 93%.
Uses
A intermediate in the synthesis of Carisoprodol
Check Digit Verification of cas no
The CAS Registry Mumber 78-26-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 78-26:
(4*7)+(3*8)+(2*2)+(1*6)=62
62 % 10 = 2
So 78-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H16O2/c1-3-4-7(2,5-8)6-9/h8-9H,3-6H2,1-2H3
78-26-2Relevant articles and documents
Catalytic Hydrogenation of Cyclic Carbonates using Manganese Complexes
Kaithal, Akash,H?lscher, Markus,Leitner, Walter
supporting information, p. 13449 - 13453 (2018/09/25)
Catalytic hydrogenation of cyclic carbonates to diols and methanol was achieved using a molecular catalyst based on earth-abundant manganese. The complex [Mn(CO)2(Br)[HN(C2H4PiPr2)2] 1 comprising commercially available MACHO ligand is an effective pre-catalyst operating under relatively mild conditions (T=120 °C, p(H2)=30–60 bar). Upon activation with NaOtBu, the formation of coordinatively unsaturated complex [Mn(CO)2[N(C2H4PiPr2)2)] 5 was spectroscopically verified, which confirmed a kinetically competent intermediate. With the pre-activated complex, turnover numbers up to 620 and 400 were achieved for the formation of the diol and methanol, respectively. Stoichiometric reactions under catalytically relevant conditions provide insight into the stepwise reduction form the CO2 level in carbonates to methanol as final product.
CARBAMATE REDUCERS OF SKELETAL MUSCLE TENSION
-
Page/Page column 10, (2010/04/23)
The present invention relates to new carbamate skeletal muscle relaxants, pharmaceutical compositions thereof, and methods of use thereof.
