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5-methyl-5-propyl-1,3-dioxan-2-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

7148-50-7

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7148-50-7 Usage

Chemical Properties

Colourless Oil

Check Digit Verification of cas no

The CAS Registry Mumber 7148-50-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,4 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7148-50:
(6*7)+(5*1)+(4*4)+(3*8)+(2*5)+(1*0)=97
97 % 10 = 7
So 7148-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H14O3/c1-3-4-8(2)5-10-7(9)11-6-8/h3-6H2,1-2H3

7148-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Methyl-5-Propyl-1,3-Dioxan-2-One

1.2 Other means of identification

Product number -
Other names 5-methyl-5-propyl-1,3-dioxan-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7148-50-7 SDS

7148-50-7Synthetic route

phosgene
75-44-5

phosgene

2-methyl-2-propyl-1,3-propanediol
78-26-2

2-methyl-2-propyl-1,3-propanediol

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

Conditions
ConditionsYield
With antipyrine; chloroform
2-methyl-2-propyl-1,3-propanediol
78-26-2

2-methyl-2-propyl-1,3-propanediol

Diethyl carbonate
105-58-8

Diethyl carbonate

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

Conditions
ConditionsYield
With sodium methylate Entfernen des entstehenden Aethanols;
With sodium 1.) toluene, 90 deg C, 30 min, 2.) toluene, 88-110 deg C; Yield given. Multistep reaction;
2-methyl-2-propyl-1,3-propanediol
78-26-2

2-methyl-2-propyl-1,3-propanediol

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at -78 - 20℃; for 16h;
2-methyl-2-propyl-1,3-propanediol
78-26-2

2-methyl-2-propyl-1,3-propanediol

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: p-toluenesulfonyl chloride; n-butyllithium
1.2: 0 - 60 °C
2.1: C49H74AlNO4; bis(triphenylphosphoranylidene)ammonium iodide / butanone / 24 h / 110 °C / 7500.75 Torr / Autoclave; Sealed tube
View Scheme
3-methyl 3-n-propyl oxetane
13911-97-2

3-methyl 3-n-propyl oxetane

carbon dioxide
124-38-9

carbon dioxide

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

Conditions
ConditionsYield
With C49H74AlNO4; bis(triphenylphosphoranylidene)ammonium iodide In butanone at 110℃; under 7500.75 Torr; for 24h; Autoclave; Sealed tube;
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

A

methanol
67-56-1

methanol

B

2-methyl-2-propyl-1,3-propanediol
78-26-2

2-methyl-2-propyl-1,3-propanediol

Conditions
ConditionsYield
With [Mn(HN(C2H4PiPr2)2)(CO)2Br]; hydrogen; sodium t-butanolate In tetrahydrofuran at 120℃; under 22502.3 Torr; for 26h; Schlenk technique; Glovebox; Autoclave;A 94%
B 98%
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

2-methyl-2-propyl-3-hydroxypropylcarbamate
1471-56-3

2-methyl-2-propyl-3-hydroxypropylcarbamate

Conditions
ConditionsYield
With ammonia
morpholine
110-91-8

morpholine

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

morpholine-4-carboxylic acid 2-hydroxymethyl-2-methyl-pentyl ester
25384-42-3

morpholine-4-carboxylic acid 2-hydroxymethyl-2-methyl-pentyl ester

methamphetamin
7632-10-2

methamphetamin

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

2-Methyl-2-propyl-3--propanol-(1)
25384-40-1

2-Methyl-2-propyl-3--propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

1-amino-3-methylbutane
107-85-7

1-amino-3-methylbutane

2-Methyl-2-propyl-3-<(3-methyl-butyl)-carbamoyl-oxy>-propanol-(1)
25384-37-6

2-Methyl-2-propyl-3-<(3-methyl-butyl)-carbamoyl-oxy>-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

2-Methyl-2-propyl-3-<(p-carboxy-phenyl)-carbamoyloxy>-propanol-(1)
25384-43-4

2-Methyl-2-propyl-3-<(p-carboxy-phenyl)-carbamoyloxy>-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

1-pentanamine
110-58-7

1-pentanamine

2-Methyl-2-propyl-3-pentyl-carbamoyloxy-propanol-(1)
25384-36-5

2-Methyl-2-propyl-3-pentyl-carbamoyloxy-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

dibutylamine
111-92-2

dibutylamine

2-Methyl-2-propyl-3-dibutylcarbamoyloxy-propanol-(1)
25384-41-2

2-Methyl-2-propyl-3-dibutylcarbamoyloxy-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

isopropylamine
75-31-0

isopropylamine

N-Mono-isopropyl-2-methyl-2-n-propylpropane-1,3-diol carbamate
25462-17-3

N-Mono-isopropyl-2-methyl-2-n-propylpropane-1,3-diol carbamate

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

diethylamine
109-89-7

diethylamine

2-Methyl-2-propyl-3-diethylcarbamoyloxy-propanol-(1)
26345-29-9

2-Methyl-2-propyl-3-diethylcarbamoyloxy-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N-butylamine
109-73-9

N-butylamine

N-Butyl-carbaminsaeure-(3-hydroxy-2-methyl-2-propyl-propylester)
23787-20-4

N-Butyl-carbaminsaeure-(3-hydroxy-2-methyl-2-propyl-propylester)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

methylamine
74-89-5

methylamine

2-Methyl-2-propyl-3-methylcarbamoyloxy-propanol-(1)
25462-15-1

2-Methyl-2-propyl-3-methylcarbamoyloxy-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

benzylamine
100-46-9

benzylamine

2-Methyl-2-propyl-3-benzylcarbamoyloxy-propanol-(1)
25384-38-7

2-Methyl-2-propyl-3-benzylcarbamoyloxy-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

2-methylallylamin
2878-14-0

2-methylallylamin

2-Methyl-2-propyl-3-<(2-methyl-allyl)-carbamoyloxy>-propanol-(1)
25384-35-4

2-Methyl-2-propyl-3-<(2-methyl-allyl)-carbamoyloxy>-propanol-(1)

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

2-Methyl-2-propyl-3-aminocarbamoyl-oxy-propanol-(1)
25649-01-8

2-Methyl-2-propyl-3-aminocarbamoyl-oxy-propanol-(1)

Conditions
ConditionsYield
With hydrazine hydrate
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

carisoprodol
78-44-4

carisoprodol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5 h / Heating
2: 80 percent / HCl / CH2Cl2 / 10 h / -2 - 2 °C
View Scheme
Multi-step reaction with 2 steps
2: (i) PhNMe2, (ii) NH3
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

morpholine-4-carboxylic acid 2-carbamoyloxymethyl-2-methyl-pentyl ester
25642-81-3

morpholine-4-carboxylic acid 2-carbamoyloxymethyl-2-methyl-pentyl ester

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

2-Methyl-2-propyl-3-isopropylaminocarbamoyloxy-propanol-(1)
25649-03-0

2-Methyl-2-propyl-3-isopropylaminocarbamoyloxy-propanol-(1)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. N2H4
2: (i), (ii) (catalytic hydrogenation)
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N.N.-Diethyl-2-methyl-2-propyl-1.3-dicarbamoyloxy-propan
25642-80-2

N.N.-Diethyl-2-methyl-2-propyl-1.3-dicarbamoyloxy-propan

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N-Isopropylamino-2-methyl-2-propyl-1,3-dicarbamoyloxy-propan
25652-06-6

N-Isopropylamino-2-methyl-2-propyl-1,3-dicarbamoyloxy-propan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. N2H4
2: (i), (ii) (catalytic hydrogenation)
3: HCl / CHCl3
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N,N-Diaethyl-N',2-dipropyl-2-methyl-1,3-dicarbamoyloxy-propan
25648-99-1

N,N-Diaethyl-N',2-dipropyl-2-methyl-1,3-dicarbamoyloxy-propan

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N-Butyl-N'-(3-methyl-butyl)-2-methyl-2-propyl-1,3-dicarbamoyl-propan
25648-93-5

N-Butyl-N'-(3-methyl-butyl)-2-methyl-2-propyl-1,3-dicarbamoyl-propan

5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

tybamate
4268-36-4

tybamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (i) PhNMe2, (ii) NH3
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N-Methyl-N'-isopropyl-2-methyl-2-propyl-propandiol-(1.3)-dicarbamat
92168-78-0

N-Methyl-N'-isopropyl-2-methyl-2-propyl-propandiol-(1.3)-dicarbamat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (i) PhNMe2, (ii) /BRN= 741851/
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N-Methyl-N'-butyl-2-methyl-2-propyl-propandiol-(1,3)-dicarbamat
93807-30-8

N-Methyl-N'-butyl-2-methyl-2-propyl-propandiol-(1,3)-dicarbamat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (i) PhNMe2, (ii) /BRN= 741851/
View Scheme
5-Methyl-5-n-propyl-1,3-dioxan-2-one
7148-50-7

5-Methyl-5-n-propyl-1,3-dioxan-2-one

N,N-Dimethyl-N'-isopropyl-2-methyl-2-propyl-propandiol-(1.3)-dicarbamat
92326-71-1

N,N-Dimethyl-N'-isopropyl-2-methyl-2-propyl-propandiol-(1.3)-dicarbamat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: (i) PhNMe2, (ii) /BRN= 605257/
View Scheme

7148-50-7Relevant academic research and scientific papers

Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules

Guo, Wusheng,Laserna, Victor,Rintjema, Jeroen,Kleij, Arjan W.

supporting information, p. 1602 - 1607 (2016/10/13)

Oxetanes are versatile building blocks in drug-related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chemistry with carbon dioxide (CO2) to afford value-added commodity chemicals, oxetane/CO2couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines and CO2to afford a variety of functionalized carbamates with excellent chemoselectivity and good yields. The process is mediated by an aluminium-based catalyst under relatively mild conditions and the developed catalytic methodology can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step. (Figure presented.).

CARBAMATE REDUCERS OF SKELETAL MUSCLE TENSION

-

Page/Page column 11, (2010/04/23)

The present invention relates to new carbamate skeletal muscle relaxants, pharmaceutical compositions thereof, and methods of use thereof.

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