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78-50-2

78-50-2

Identification

  • Product Name:Phosphine oxide,trioctyl-

  • CAS Number: 78-50-2

  • EINECS:201-121-3

  • Molecular Weight:386.642

  • Molecular Formula: C24H51OP

  • HS Code:32019090

  • Mol File:78-50-2.mol

Synonyms:Cyanex 921;Hostarex PX 324;TOPO;Tri-n-octylphosphine oxide;Trioctylphosphine oxide;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi,Hazard

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH317 May cause an allergic skin reaction H361 Suspected of damaging fertility or the unborn child

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
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  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:Trioctylphosphine oxide
  • Packaging:2.5g
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:Tri-n-octylphosphine Oxide >95.0%(GC)
  • Packaging:100g
  • Price:$ 105
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Tri-n-octylphosphine Oxide >95.0%(GC)
  • Packaging:25g
  • Price:$ 37
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Trioctylphosphine oxide, 99% TOPO
  • Packaging:100g
  • Price:$ 122
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Trioctylphosphine oxide, min. 90% TOPO
  • Packaging:500g
  • Price:$ 187
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Trioctylphosphine oxide, min. 90% TOPO
  • Packaging:100g
  • Price:$ 47
  • Delivery:In stock
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  • Manufacture/Brand:Strem Chemicals
  • Product Description:Trioctylphosphine oxide, 99% TOPO
  • Packaging:25g
  • Price:$ 38
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Trioctylphosphine oxide for extraction analysis, ≥98.5%
  • Packaging:10g
  • Price:$ 79.5
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Trioctylphosphine oxide Selectophore
  • Packaging:25g
  • Price:$ 47.5
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Trioctylphosphine oxide Selectophore
  • Packaging:1g
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Relevant articles and documentsAll total 22 Articles be found

Martin et al.

, p. 96,97 (1961)

Single-stage synthesis of alkyl-H-phosphinic acids from elemental phosphorus and alkyl bromides

Gusarova, Nina K.,Sutyrina, Anastasiya O.,Kuimov, Vladimir A.,Malysheva, Svetlana F.,Belogorlova, Natalia A.,Volkov, Pavel A.,Trofimov, Boris A.

, p. 328 - 330 (2019/06/13)

Elemental phosphorus (red or white) reacts with alkyl bromides at 60–62 °C in the phase-transfer catalytic system KOH/H2O/PhMe/Et3BnNCl to afford alkyl-H-phosphinic acids in up to 47% yield.

Photolytic C-O Bond Cleavage with Quantum Dots

Enright, Michael J.,Gilbert-Bass, Kito,Sarsito, Harrison,Cossairt, Brandi M.

, p. 2677 - 2682 (2019/04/25)

Quantum dots are used as photoredox catalysts to drive bond cleavage in lignin model substrates. Cadmium selenide quantum dots selectively cleave C-O bonds with yields comparable to the best transition-metal-based molecular photocatalysts, thereby emulating depolymerization of the β-O-4 linkages that account for 45-60% of all linkers in native lignin. Compared to their molecular catalyst counterparts, the quantum dots demonstrate higher turnover frequencies, higher surface tunability for solvent versatility, and lower catalyst loading under mild, ambient temperature reaction conditions. The robust nature and solvent versatility of these quantum dot photoredox catalysts enable a direct, single-vessel route to convert benzylic alcohols (a majority of species in native and processed lignin) into high-value guaiacols and acetophenones without any prerequisite filtration, purification, or solvent change.

A trioctylphosphine phosphine oxide compound and its preparation method

-

Paragraph 0058; 0059, (2018/01/13)

The invention aims to provide a trioctylphosphine oxide compound and a preparation method thereof, which is high in yield, low in cost and moderate in reaction conditions. In order to fulfill the aim of the invention, the technical scheme of the invention is that the preparation method for the trioctylphosphine oxide compound comprises the following steps of: preparing trioctylphosphine oxide from sodium hypophosphite by performing octene addition, trichlorosilane reduction, bromoalkane addition and hydrolysis in turn; or preparing the trioctylphosphine oxide from the sodium hypophosphite by performing the octene addition, the trichlorosilane reduction, the hydrolysis and the octene addition again in turn; or preparing the trioctylphosphine oxide from the sodium hypophosphite by performing the octene addition, the trichlorosilane reduction and alcoholysis in turn. According to the synthesis method provided by the invention, the selected raw materials are easy to obtain; the addition reaction is performed on the sodium hypophosphite and octene, so that the reaction conditions are moderate and are easy to control; the operation safety is enhanced; the reaction yield is high and can reach over 90 percent; the trioctylphosphine oxide is convenient to purify; and the product purity is high.

Function of substituents in coordination behaviour, thermolysis and ligand crossover reactions of phosphine oxides

Pavankumar,Goud, E. Veerashekhar,Selvakumar,Kumar, S. K. Ashok,Sivaramakrishna, Akella,Vijayakrishna, Kari,Rao, C. V. S. Brahmananda,Sabharwal,Jha, Prakash C.

, p. 4727 - 4736 (2015/03/03)

Some selected aminophosphine oxides (AmPOs) of the type OP(NMe2)3, OPPh(NMe2)2, OP(NC2H4O)3, OPPh(NC2H4O)2 and their corresponding La(III) and Th(IV) complexes are synthesized and analyzed by FT-IR, 1H-NMR, 31P{1H}-NMR, elemental analysis and TGA data. The coordination behavior of AmPOs was compared with some of the known ligands that include trioctylphosphine oxide (TOPO), tributylphosphate (TBP) and diethylphosphite (DEP). Thermogravimetric analysis of these complexes showed a distinct decomposition trend either by a single step or multi-step elimination of ligand species, which are strongly dependent on the electronic and steric behaviour of substituents on the P=O group and the nature of the metal. Phosphine oxide based La(III) and Th(IV) complexes undergo three unique intermolecular ligand exchange reactions at room temperature: relative competition among phosphine oxides to form a strong complex by exchanging the weaker ligand and complete ligand transfer from La(III) to Th(IV) metal centers. Ligand crossover is well controlled by priority rules and the trend is TOPO > TBP > DEP > AmPO > Ph3PO. This tendency closely agrees with the stability constants of metal complexes. On comparison, Th(IV) complexes showed slightly higher stability than La(III) analogues.

Synthesis, purification, and characterization of phosphine oxides and their hydrogen peroxide adducts

Hilliard, Casie R.,Bhuvanesh, Nattamai,Gladysz, John A.,Bluemel, Janet

experimental part, p. 1742 - 1754 (2012/03/22)

Reactions of the tertiary phosphines R3P (R = Me, Bu, Oct, Cy, Ph) with 35% aqueous H2O2 gives the corresponding oxides as the H2O2 adducts R3PO·(H 2O2)x (x = 0.5-1.0). Air oxidation leads to a mixture of products due to the insertion of oxygen into one or more P-C bonds. 31P NMR spectroscopy in solution and in the solid state, as well as IR spectroscopy reveal distinct features of the phosphine oxides as compared to their H2O2 adducts. The single crystal X-ray analyses of Bu3PO and [Cy3PO·(H2O2)] 2 show a PO stacking motif for the phosphine oxide and a cyclic structure, in which the six oxygen atoms exhibit a chair conformation for the dimeric H2O2 adduct. Different methods for the decomposition of the bound H2O2 and the removal of the ensuing strongly adsorbed H2O are evaluated. Treating R 3PO·(H2O2)x with molecular sieves destroys the bound H2O2 safely under mild conditions (room temperature, toluene) within one hour and quantitatively removes the adsorbed H2O from the hygroscopic phosphine oxides within four hours. At 60°C the entire decomposition/drying process is complete within one hour.

Process route upstream and downstream products

Process route

C<sub>24</sub>H<sub>51</sub>BrClP

C24H51BrClP

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
With water; In toluene; at 20 ℃; for 1h;
92.6%
octanol
111-87-5

octanol

dioctylphosphinyl chloride
7539-86-8

dioctylphosphinyl chloride

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
In chloroform; at 50 ℃; for 2h;
95.1%
oxyde de dioctyl phosphine
3011-82-3

oxyde de dioctyl phosphine

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
With acetic acid; at 120 - 135 ℃; for 8h;
81.4%
cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
With fluorosulfonylchloride; In dichloromethane; for 1h; Ambient temperature;
98%
TOP; With water; dihydrogen peroxide; In toluene; at 0 - 20 ℃; for 12h; Inert atmosphere;
In toluene; at 20 ℃; for 4h; Molecular sieve;
90%
In 1,2,4-trimethylbenzene; at 25 ℃; for 1h; Inert atmosphere;
With selenium; octadec-1-ene;
1-bromo-octane
111-83-1

1-bromo-octane

oxyde de dioctyl phosphine
3011-82-3

oxyde de dioctyl phosphine

cyanex-921
78-50-2

cyanex-921

octylphosphinic acid
6196-68-5

octylphosphinic acid

Conditions
Conditions Yield
With potassium hydroxide semihydrate; phosphorus; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 60 - 62 ℃; for 5h; Reagent/catalyst; Inert atmosphere;
19%
4-chlorophenylphosphonoyl dichloride
22585-81-5

4-chlorophenylphosphonoyl dichloride

cyanex-921
78-50-2

cyanex-921

4-chlorophenyldichlorophosphine
1005-33-0

4-chlorophenyldichlorophosphine

Conditions
Conditions Yield
In dichloromethane;
84%
n-chlorooctane
111-85-3

n-chlorooctane

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
In toluene; Petroleum ether;
39%
With hydrogenchloride; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; water;
n-chlorooctane
111-85-3

n-chlorooctane

oxyde de dioctyl phosphine
3011-82-3

oxyde de dioctyl phosphine

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
With sodium amide; tert-butyl alcohol; In tetrahydrofuran; at 40 ℃; for 0.833333h;
72%
1-bromo-octane
111-83-1

1-bromo-octane

oxyde de dioctyl phosphine
3011-82-3

oxyde de dioctyl phosphine

cyanex-921
78-50-2

cyanex-921

Conditions
Conditions Yield
With phosphorus; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; at 60 - 65 ℃; for 6h; Yield given;
3-(4-chlorophenyl)-4-trioctylphosphiniminofurazan
106446-20-2

3-(4-chlorophenyl)-4-trioctylphosphiniminofurazan

cyanex-921
78-50-2

cyanex-921

azoxy(4-chlorophenylfurazan)
106446-23-5

azoxy(4-chlorophenylfurazan)

Conditions
Conditions Yield
With 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; for 2h; Heating;
60%

Global suppliers and manufacturers

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  • Hangzhou Dingyan Chem Co., Ltd
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  • Simagchem Corporation
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  • Chemwill Asia Co., Ltd.
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  • Amadis Chemical Co., Ltd.
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  • Shanghai Upbio Tech Co.,Ltd
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