787-70-2Relevant articles and documents
Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts
Yin, Shenxiang,Zheng, Qingshu,Chen, Jie,Tu, Tao
, p. 165 - 172 (2022/03/23)
The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcohols to corresponding carboxylic acids has been accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 × 104 turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry.
METHOD OF MANUFACTURING BIPHENYLDICARBOXYLIC ACID
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Paragraph 0115-0118, (2021/05/25)
A method for producing biphenyldicarboxylic acid according to example embodiments of the present invention is to react a biphenyl (biphenyl) with an acyl halide (acyl halide) - based compound to form an agent 1 intermediate. 1 Intermediate and 3 nd amine-based compound are reacted to form a 2 intermediate, and the step 2 intermediate is base-treated. 4,4 ' - Biphenyldicarboxylic acid can be efficiently produced.
Electrochemical coupling halobenzene into biphenyl on a reusable Pd nanoparticle-coated carbon-paper electrode at ambient conditions
Wang, Chao-Nan,Lu, Yong-Heng,Liu, Yue,Liu, Jun,Yang, Yao-Yue,Zhao, Zhi-Gang
, p. 3997 - 4003 (2021/03/06)
Electrochemical organic synthesis (EOS) employing electrons to directly activate the reactants can readily complete the chemical conversion under mild conditions. Here, it presented an efficient electrochemical coupling halobenzene into biphenyl on a Pd nanoparticle-coated cathode. The biphenyl product can be obtained with a yield up to 77% at 35 mA, 6 h (3.9 F mol?1). In addition, after consecutive fifth run of the coupling reaction, the yield still remained atca.40%, suggesting its considerable recyclable capacity. In addition, the preliminary kinetics studyviathe off-line gas chromatography analysis of the reaction mixture shows a two-section reaction process, including the introduction process (IP) and fast conversion process (FCP). Further, the estimated reaction kinetics constant value of 0.196 min?1for FCP suggests a more effective conversion than that obtained by the previous study. This study adopts a simple way to fabricate a low-cost and reusable Pd electrode, achieving a high-efficiency electrochemical strategy for the Ullmann-type coupling reaction at mild conditions, and holds a great promise to extend this synthesis route to other important organic synthesis.
Cobalt-catalyzed cross-coupling reactions of aryl- And alkylaluminum derivatives with (hetero)aryl and alkyl bromides
Dilauro, Giuseppe,Messa, Francesco,Bona, Fabio,Perrone, Serena,Salomone, Antonio
supporting information, p. 10564 - 10567 (2021/10/19)
A simple cobalt complex, such as Co(phen)Cl2, turned out to be a highly efficient and cheap precatalyst for a host of cross-coupling reactions involving aromatic and aliphatic organoaluminum reagents with aryl, heteroaryl and alkyl bromides. New C(sp2)-C(sp2) and C(sp2)-C(sp3) bonds were formed in good to excellent yields and with high chemoselectivity, under mild reaction conditions.
Preparation method of 4,4'-biphenyldicarboxylic acid
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Paragraph 0023-0034, (2020/06/02)
The invention discloses a preparation method of 4,4'-biphenyldicarboxylic acid, which specifically comprises the following steps: S1, preparation of raw materials, S2, 4,4'-biphenyldicarboxylic acid crude product preparation, S3, reaction mother liquor treatment, S4, 4,4'-biphenyldicarboxylic acid refining pretreatment, and S5, 4,4'-biphenyldicarboxylic acid refining. The invention relates to thetechnical of chemical product preparation and discloses a preparation method of 4,4'-biphenyldicarboxylic acid. A two-stage alkaline water spraying device can be adopted through tail gas absorption toreach standard emission; according to the process, provincial security association safety and reliability argumentation is carried out; in addition, the industrial yield of the reaction reaches 98% or above; the content is 99.5% or above, the yield is high, the quality is good and no pollution is caused to the environment. The purposes of improving the yield and purity of the 4,4'-diphenyldicarboxylic acid and being environmentally friendly are well achieved, and therefore the method is quite beneficial to production of 4, 4'-diphenyldicarboxylic acid production enterprises.
Method for preparing aromatic carboxylic acid compound
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Paragraph 0141-0143; 0152-0155; 0177, (2020/02/14)
The invention discloses a method for preparing an aromatic carboxylic acid compound. The method comprises the following steps: 1) heating carbon dioxide and hydrosilane in the presence of a copper catalyst in a reaction medium A; and 2) adding a reaction medium B, aryl halide, a palladium catalyst and a base to the reaction mixture in the step 1), sealing the reaction system, and performing a heating reaction. The method has the advantages that raw materials are simple and easy to obtain, the raw materials are cheap and stable, the catalyst is common, easy to obtain and stable, the reaction conditionsaremild, the aftertreatment is simple, the yield is high, and the like.
PREPARATION AND USE OF BIPHENYLDICARBOXYLIC ACIDS
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Paragraph 0057, (2019/08/26)
A process for selective oxidation of at least one dimethylbiphenyl compound to the corresponding biphenyldicarboxylic acid, where the dimethylbiphenyl compound is supplied to at least one reaction zone together with an acidic solvent, an oxidizing medium, and a catalyst comprising cobalt, manganese, and bromine. The dimethylbiphenyl compound and oxidizing medium are contacted with the catalyst in the at least one reaction zone at a temperature of 150 to 210°C to oxidize the dimethylbiphenyl compound to the corresponding biphenyldicarboxylic acid. The supply of dimethylbiphenyl compound to the at least one reaction zone is then terminated, but the supply of oxidizing medium and catalyst is continued with the at least one reaction zone at a temperature of 150 to 210°C. A reaction product comprising at least 95 wt% of the biphenyldicarboxylic acid based on the total weight of oxidized dimethylbiphenyl compound is then recovered from the at least one reaction zone.
Synthesis method for 4,4'-biphenyldicarbox ylic acid
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Paragraph 0027; 0030; 0031; 0034; 0035; 0038; 0039; 0042, (2019/01/23)
The invention discloses a synthesis method for 4,4'-biphenyldicarbox ylic acid. The method comprises the following specific steps: performing radical chlorination on 4,4'-dimethyl biphenyl used as a raw material under the effect of light or an initiator so as to generate 4,4'-di(trichloromethyl)biphenyl; then performing hydrolysis reaction under an alkaline condition so as to obtain 4,4'-biphenyldicarbox ylic acid; and performing an aftertreatment process, thereby obtaining a finished product. The synthesis method for 4,4'-biphenyldicarbox ylic acid is rich in raw material sources, low in rawmaterial price, simple in synthesis process, high in product recovery rate, free from any purification, high in product yield and product purity, less in pollution, high in conversion rate, high in economical efficiency and suitable for industrial large-scale production.
Organic Solvent-Free, Pd(II)-Salan Complex-Catalyzed Synthesis of Biaryls via Suzuki-Miyaura Cross-Coupling in Water and Air
Bunda, Szilvia,Udvardy, Antal,Voronova, Krisztina,Joó, Ferenc
, p. 15486 - 15492 (2019/01/03)
With use of a Pd(II)-sulfosalan complex as a water-soluble catalyst, we have developed an efficient synthesis of biaryls via Suzuki-Miyaura cross-coupling in water under aerobic conditions. The water-insoluble target molecules were isolated by simple filtration in analytical purity after washing with 0.01 M aqueous HCl (20 examples). In most cases, palladium contamination was below 5 ppm considered acceptable for active pharmaceutical ingredients. The established method is scalable, reproducible, and provides biaryl products in isolated yields up to 91%.
Tandem one-pot CO2 reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids
Paridala, Kumaraswamy,Lu, Sheng-Mei,Wang, Meng-Meng,Li, Can
supporting information, p. 11574 - 11577 (2018/10/31)
The present study discloses the synthesis of aryl/vinyl carboxylic acids from Csp2-bound halides (Cl, Br, I) in a carbonylative path by using silyl formate (from CO2 and hydrosilane) as an instant CO-surrogate. Hydrosilane provides hydride for reduction and its oxidation product silanol serves as a coupling partner. Mono-, di-, and tri-carboxylic acids were obtained from the corresponding aryl/vinyl halides.
