85-40-5Relevant articles and documents
Preparation method of 1,2,3,6-tetrahydrophthalimide
-
Paragraph 0061; 0063; 0064; 0066; 0067; 0069; 0070; 0072, (2020/01/12)
The invention provides a preparation method of 1,2,3,6-tetrahydrophthalimide. The preparation method comprises the following steps: a) mixing 1,2,3,6-tetrahydrophthalic anhydride with an ammonia source, and carrying out a low-temperature reaction to obtain a reaction intermediate, wherein the temperature of the low-temperature reaction is 0-30 DEG C; and b) carrying out a dehydration ring-closurereaction on the reaction intermediate obtained in the step a) in the presence of a solvent, carrying out cooling and recrystallizing to obtain the 1,2,3,6-tetrahydrophthalimide. According to the preparation method provided by the invention, a step-by-step method is adopted, a ring-opening reaction and a ring-closure reaction are separated to reduce side reactions, and a conventional heating process is not carried out in the whole process, so the generation of viscous colloidal byproducts in a temperature range of 80-110 DEG C can be effectively avoided, and high selectivity is realized, thereby improving product purity; meanwhile, reaction operation in a solvent is simple, conditions are easy to control, and environment friendliness is achieved; the overall two-step yield can reach 95% orhigher; moreover, no waste gas is generated in the reaction process, and redundant ammonia gas can be recycled, so environmental production cost is greatly saved.
AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES
-
Page/Page column 28; 29, (2013/03/26)
The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C1 represents H or -CH3, R6 and R7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.
INCORPORATION OF MOLECULAR NITROGEN INTO AMIDES AND IMIDES BY USE OF TITANIUM-NITROGEN COMPLEXES
Mori,Miwako,Uozumi, Yasuhiro,Shibasaki, Masakatsu
, p. 6187 - 6190 (2007/10/02)
Molecular nitrogen was incorporated into amides and imides by the reaction of titanium-nitrogen complex 1 prepared from TiCl3 and Mg under N2 in THF with acyl chlorides 3.The cyclic imides 10, 12, 14 and quinazoline 16 were obtained by the reaction of isocyanate complex 6 generated by fixation of CO2 into titanium complex 1 with the corresponding cyclic anhydrides 9, 11, 13 and benzoxazone 15.